Product image of Memolan (Memantine Hydrochloride) supplied by GNH India

Memolan

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memolan (Memantine Hydrochloride)

Memantine Hydrochloride, the active ingredient in Memolan, is a NMDA receptor antagonist presented as a tablet for oral use. It is indicated for the symptomatic treatment of moderate to severe Alzheimer’s disease in adults.

GNH India supplies Memolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

Memolan is used in the management of Alzheimer’s disease, acting on glutamatergic neurotransmission to improve symptoms.

  • Moderate to severe Alzheimer’s disease: helps maintain cognition, daily function and behavior in affected patients.
  • Alzheimer’s disease with behavioral disturbances: may reduce agitation and improve overall patient stability.
  • Cognitive decline due to Alzheimer’s disease: supports modest improvements in memory and executive function.

How It Works

  • Memantine Hydrochloride acts as a non‑competitive antagonist at the NMDA (N‑methyl‑D‑aspartate) receptor. By binding to the receptor-associated ion channel, it reduces excessive calcium influx caused by glutamate over‑activation, thereby decreasing excitotoxic neuronal damage that contributes to cognitive decline in Alzheimer’s disease.

Side Effects

Common Side Effects

  • Dizziness: mild to moderate vertigo or light‑headedness.
  • Headache: transient cranial discomfort.
  • Constipation: reduced bowel movements.
  • Confusion: occasional disorientation.
  • Fatigue: general tiredness.
  • Hypertension: mild increase in blood pressure.

Serious or Rare Side Effects

  • Seizures: rare occurrence of convulsive episodes.
  • Cardiac arrhythmia: irregular heart rhythms.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction: elevated liver enzymes.
  • Suicidal thoughts: emergent mood changes.
  • Allergic anaphylaxis: acute hypersensitivity response.

Precautions & Warnings

Memolan should be used with consideration of patient‑specific factors and proper storage.

  • Renal impairment: assess kidney function and adjust therapy as needed.
  • History of seizures: monitor closely for neurologic events.
  • Cardiovascular disease: observe blood pressure and heart rhythm.
  • Concurrent NMDA antagonists: avoid combined use to prevent additive toxicity.
  • Pregnancy and lactation: safety not established; weigh risks and benefits.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Memolan may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

  • Amantadine: increased risk of central nervous system adverse effects.
  • Ketamine: additive NMDA antagonism may lead to excessive inhibition.
  • Other NMDA antagonists: concurrent use can amplify neuro‑psychiatric toxicity.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may diminish therapeutic benefit.
  • Diuretics: can raise plasma concentrations of memantine.
  • CNS depressants (e.g., benzodiazepines): monitor for enhanced sedation.

Frequently Asked Questions

Memolan contains memantine hydrochloride and is prescribed for the symptomatic treatment of moderate to severe Alzheimer’s disease, helping to improve cognition, daily functioning, and behavioral symptoms in affected patients.

Memantine hydrochloride acts as a non‑competitive antagonist of the NMDA receptor, reducing excessive glutamate‑mediated calcium influx and thereby limiting excitotoxic neuronal damage that contributes to cognitive decline in Alzheimer’s disease.

The dosage of Memolan is individualized by the prescribing clinician based on the patient’s clinical condition, renal function, and tolerability. Specific dosing regimens should be obtained from a qualified healthcare professional.

Safety data for memantine hydrochloride in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and decisions should be made in consultation with a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Memolan (memantine) belongs to the NMDA receptor antagonist class, differing from cholinesterase inhibitors such as donepezil. While cholinesterase inhibitors enhance acetylcholine activity, memantine reduces glutamate‑induced excitotoxicity, and it is typically used in moderate to severe stages or when patients cannot tolerate cholinesterase inhibitors.

Memolan should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Memolan is taken orally, usually once daily, with or without food, as directed by a healthcare professional. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious risks include seizures, cardiac arrhythmias, severe skin reactions such as Stevens‑Johnson syndrome, hepatic dysfunction, and emergent suicidal thoughts. Patients should be monitored regularly for any of these adverse events and seek immediate medical attention if they occur.

Memolan is contraindicated in patients with known hypersensitivity to memantine or any of its excipients, and it should be used with caution in individuals with severe renal impairment, uncontrolled seizures, or those taking other NMDA antagonists. A healthcare professional should evaluate suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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