Product image of Menadex (Dexketoprofen) supplied by GNH India

Menadex

Active Ingredient:
Dexketoprofen
Origin:
EU

Menadex (Dexketoprofen)

Dexketoprofen, the active ingredient in Menadex, is a non‑steroidal anti‑inflammatory drug presented as an oral dosage form for oral use. It provides analgesic and anti‑inflammatory effects for mild to moderate pain, musculoskeletal discomfort, post‑operative pain and other inflammatory conditions.
GNH India supplies Menadex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Dexketoprofen is employed in the management of pain and inflammation across several clinical settings.

  • Mild to moderate pain: delivers rapid analgesic relief for everyday discomfort.
  • Musculoskeletal pain: reduces inflammation and improves mobility in conditions such as sprains or strains.
  • Post‑operative pain: helps control pain after surgical procedures.
  • Inflammatory conditions: alleviates symptoms of acute inflammatory disorders.

How It Works

  • Dexketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis lowers peripheral sensitisation of nociceptors, thereby reducing pain perception and inflammatory swelling.

Side Effects

Dexketoprofen may cause a range of adverse reactions, which are categorised by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Headache: transient cranial discomfort.
  • Dyspepsia: indigestion or upper abdominal fullness.
  • Dizziness: occasional light‑headed sensation.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration: potentially life‑threatening.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Renal impairment: reduced kidney function, especially with prolonged use.
  • Anaphylaxis: acute allergic response requiring immediate medical attention.

Precautions & Warnings

Before initiating therapy with Dexketoprofen, consider the following safety measures.

  • Renal function assessment: evaluate kidney health, especially in elderly patients.
  • Hepatic function assessment: monitor liver enzymes in patients with liver disease.
  • Use lowest effective dose: limit exposure while achieving pain control.
  • Avoid in known hypersensitivity: discontinue if allergic reactions occur.
  • Caution with anticoagulants: increased risk of bleeding when combined.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Dexketoprofen can interact with several medication classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): may increase bleeding tendency.
  • ACE inhibitors or ARBs: potential reduction in renal function.
  • Lithium: possible increase in lithium serum levels.

Frequently Asked Questions

Menadex, containing dexketoprofen, is indicated for the relief of mild to moderate pain, musculoskeletal discomfort, post‑operative pain and other acute inflammatory conditions where rapid analgesia and anti‑inflammatory action are required.

Dexketoprofen blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, reducing the production of prostaglandins that sensitize nerve endings. This inhibition diminishes both pain signals and the inflammatory response at the site of injury.

The appropriate dose of Menadex is determined by the prescribing healthcare professional based on the patient’s condition, age, renal and hepatic status, and other individual factors. Patients should follow the prescriber’s instructions precisely.

Safety data for dexketoprofen in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Menadex product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Dexketoprofen is the S‑enantiomer of ketoprofen, offering faster onset of analgesia and potentially lower gastrointestinal irritation compared with some traditional NSAIDs. However, its overall safety profile remains similar, and choice of therapy should consider individual patient risk factors and clinical response.

Menadex should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Menadex is taken orally, usually with a full glass of water. It may be taken with or without food, but patients who experience stomach upset are advised to take it with meals to minimise gastrointestinal discomfort.

Serious risks include gastrointestinal bleeding or ulceration, severe skin reactions such as Stevens‑Johnson syndrome, renal impairment, and anaphylactic reactions. Patients should seek immediate medical attention if they notice signs of bleeding, rash, swelling, or difficulty breathing.

Menadex is contraindicated in individuals with known hypersensitivity to dexketoprofen or other NSAIDs, those with active gastrointestinal ulceration, severe renal or hepatic impairment, and patients who are currently taking anticoagulants without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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