Product image of Menadion Scanpharm (Phytomenadione) supplied by GNH India

Menadion Scanpharm

Active Ingredient:
Phytomenadione
Origin:
EU

Menadion Scanpharm (Phytomenadione)

Phytomenadione, the active ingredient in Menadion Scanpharm, is a Vitamin K presented as an oral preparation for use in patients requiring correction of vitamin K deficiency or reversal of anticoagulant‑induced bleeding. It acts as a hemostasis agent by supporting the activation of clotting factors II, VII, IX and X, thereby helping to restore normal coagulation.

GNH India supplies Menadion Scanpharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Scanpharm A/S

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Indications & Clinical Uses

Menadion Scanpharm provides vitamin K activity for disorders of coagulation and related therapeutic pathways.

  • Vitamin K deficiency: restores normal clotting factor activation and reduces bleeding risk.
  • Anticoagulant‑related bleeding: reverses excess anticoagulation to control hemorrhage.
  • Pre‑surgical preparation: ensures adequate coagulation status before invasive procedures.

How It Works

  • Phytomenadione serves as a cofactor for the enzyme gamma‑glutamyl carboxylase, enabling the carboxylation of glutamic acid residues on clotting factors II, VII, IX and X. This post‑translational modification converts the factors into their active forms, allowing the coagulation cascade to proceed and correcting vitamin K deficiency or anticoagulant‑induced coagulopathy.

Side Effects

Adverse reactions may occur with oral vitamin K preparations.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Vomiting: occasional emesis.
  • Diarrhea: loose stools.
  • Abdominal pain: discomfort in the stomach area.
  • Headache: transient cranial pain.
  • Rash: mild skin irritation.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Severe hypersensitivity: swelling, itching, or difficulty breathing.
  • Thrombosis: unexpected clot formation.
  • Hemolysis: breakdown of red blood cells.
  • Elevated liver enzymes: indication of hepatic stress.
  • Stevens‑Johnson syndrome: rare severe skin reaction.

Precautions & Warnings

When prescribing Menadion Scanpharm, clinicians should consider several safety measures.

  • Dose adjustment in liver disease: monitor hepatic function and modify dose if needed.
  • Monitor coagulation parameters: check INR or PT regularly during therapy.
  • Avoid in patients with known hypersensitivity: discontinue if allergic reaction occurs.
  • Caution with concurrent warfarin: vitamin K may diminish anticoagulant effect.
  • Pregnancy considerations: safety not established; use only if benefit outweighs risk.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Phytomenadione may interact with several medicines, requiring attention to the level of interaction.

Major Interactions (Avoid)

  • Warfarin: may reduce anticoagulant effect and destabilize INR control.
  • Broad‑spectrum antibiotics (e.g., cephalosporins): can impair gut flora synthesis of vitamin K, altering efficacy.
  • Bile acid sequestrants (e.g., cholestyramine): may decrease oral absorption of vitamin K.

Moderate Interactions (Monitor Closely)

  • Vitamin E supplements: potential interference with clotting mechanisms.
  • Heparin: additive anticoagulant effect may increase bleeding risk.
  • Other vitamin K‑containing products: concurrent use may lead to excess vitamin K activity.

Frequently Asked Questions

Menadion Scanpharm is an oral vitamin K preparation used to treat vitamin K deficiency and to reverse bleeding caused by anticoagulant therapy. It helps restore normal clotting factor activity, reducing the risk of hemorrhage in patients with impaired coagulation.

Phytomenadione acts as a cofactor for gamma‑glutamyl carboxylase, an enzyme that adds a carboxyl group to specific glutamic acid residues on clotting factors II, VII, IX and X. This modification activates the factors, enabling the blood‑clotting cascade to function properly.

The dose of Menadion Scanpharm is determined by a qualified prescriber based on the patient’s clinical condition, laboratory results and response to therapy. Healthcare professionals adjust the regimen to achieve the desired correction of vitamin K status.

Safety data for phytomenadione during pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a healthcare provider.

To place an order, submit an enquiry on the Menadion Scanpharm product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Menadion Scanpharm contains phytomenadione, a plant‑derived form of vitamin K, similar in activity to synthetic vitamin K1 (phytonadione). Both correct deficiency, but formulation differences may affect absorption speed and stability. Clinicians choose based on availability, patient tolerance and specific therapeutic needs.

Store Menadion Scanpharm at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use.

Menadion Scanpharm is administered orally. The tablet or liquid is taken by mouth with water, following the dosage instructions provided by the prescribing clinician.

Serious adverse events, although rare, include anaphylaxis, severe hypersensitivity reactions, unexpected thrombosis, hemolysis and severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience signs of a severe allergic response or unexplained clot formation.

Menadion Scanpharm should be avoided in individuals with a known hypersensitivity to phytomenadione or any excipients in the formulation. Caution is also advised for patients with severe liver disease, uncontrolled bleeding disorders, or those taking medications that may interact significantly, such as warfarin, without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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