Product image of Menec (Tibolone) supplied by GNH India

Menec

Active Ingredient:
Tibolone
Origin:
EU

Menec (Tibolone)

Tibolone, the active ingredient in Menec, is a synthetic steroid (progestogen/estrogen/androgen) presented as an oral tablet for oral use. It is used to alleviate menopausal symptoms and to help prevent bone loss in post‑menopausal women.
GNH India supplies Menec as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Farmitalia S.R.L.

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Indications & Clinical Uses

  • Menec (tibolone) is indicated for conditions within the hormone replacement therapy pathway, addressing menopausal and bone health concerns.
  • Menopausal symptoms: reduces frequency and severity of hot flashes and night sweats.
  • Post‑menopausal osteoporosis: helps maintain bone mineral density and reduces fracture risk.
  • Vasomotor disturbances: improves overall quality of life related to hormonal changes.

How It Works

  • Tibolone is metabolized into active compounds that bind to estrogen, progesterone, and androgen receptors. By simultaneously providing estrogenic, progestogenic, and androgenic activity, it modulates hormonal pathways that control thermoregulation, mood, and bone remodeling, thereby relieving menopausal vasomotor symptoms and supporting skeletal health.

Side Effects

Tibolone may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea or abdominal discomfort.
  • Headache or dizziness.
  • Breast tenderness or enlargement.
  • Vaginal bleeding or spotting.
  • Weight gain or fluid retention.
  • Mood changes such as irritability.

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism.
  • Stroke or transient ischemic attack.
  • Liver dysfunction or jaundice.
  • Unexplained vaginal bleeding.
  • Breast cancer development.
  • Severe allergic reactions (rash, swelling, difficulty breathing).

Precautions & Warnings

  • Before initiating Menec, consider the following safety measures.
  • Contraindicated in pregnancy: avoid use in pregnant women.
  • Breast cancer history: assess risk before prescribing.
  • Liver disease: monitor hepatic function regularly.
  • Cardiovascular risk: evaluate for thromboembolic disorders.
  • Bone health monitoring: periodic bone density assessments recommended.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and light.

Avoid Interactions

Tibolone can interact with several medications, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • CYP3A4 inhibitors (e.g., ketoconazole): may raise tibolone levels.
  • Hormonal contraceptives: potential additive estrogenic effects.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: possible alteration of blood pressure control.
  • Antidiabetic agents: monitor glucose levels.
  • Thyroid hormones: may affect thyroid function tests.

Frequently Asked Questions

Menec contains tibolone, which is prescribed to relieve menopausal vasomotor symptoms such as hot flashes and night sweats, and to help prevent bone loss in post‑menopausal women, reducing the risk of osteoporosis.

Tibolone is converted into metabolites that bind estrogen, progesterone, and androgen receptors. This mixed hormonal activity mimics natural hormones, providing relief from menopausal symptoms while supporting bone remodeling processes.

The appropriate dose of Menec is determined by a qualified prescriber based on the individual’s clinical condition, response, and safety considerations. Patients should follow the prescribing information provided by their healthcare professional.

Menec is contraindicated in pregnancy and should not be used by women who are pregnant or may become pregnant. Its safety during breastfeeding has not been established, and it is generally avoided in lactating women.

To order Menec, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Unlike traditional estrogen‑only or combined estrogen‑progestogen therapies, tibolone provides a balanced estrogenic, progestogenic, and androgenic profile. This may result in fewer estrogen‑related side effects for some patients, but individual response and risk factors should guide therapy selection.

Menec should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Menec is taken orally, usually as a tablet, with or without food as directed by the prescribing clinician. The exact timing and frequency are determined by the healthcare provider.

Serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, stroke, liver dysfunction, and the potential for breast cancer. Patients should be monitored regularly for any signs of these conditions.

Menec is contraindicated in women who are pregnant, have a history of breast cancer, have active liver disease, or have unexplained vaginal bleeding. It should also be used with caution in patients with cardiovascular risk factors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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