Product image of Menjugate (N. Meningitidis Group C (Strain C11) Oligosaccharide Conjugated To Corynebacterium Diphtheriae Crm19) supplied by GNH India

Menjugate

Active Ingredient:
N. Meningitidis Group C (Strain C11) Oligosaccharide Conjugated To Corynebacterium Diphtheriae Crm19
Origin:
EU

Menjugate (N. Meningitidis Group C (Strain C11) Oligosaccharide Conjugated To Corynebacterium Diphtheriae Crm19)

N. meningitidis Group C (Strain C11) Oligosaccharide Conjugated To Corynebacterium Diphtheriae Crm19, the active ingredient in Menjugate, is a vaccine presented as a vaccine for intramuscular use. It prevents invasive disease caused by Neisseria meningitidis serogroup C in infants, children, adolescents and adults.

GNH India supplies Menjugate as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Gsk Vaccines S.R.L.

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Indications & Clinical Uses

Menjugate is a meningococcal group C conjugate vaccine used to prevent infections caused by Neisseria meningitidis serogroup C.

  • Invasive meningococcal disease (serogroup C): induces protective immunity to prevent meningitis, septicemia and related severe infections
  • Community outbreaks of serogroup C: reduces transmission and incidence in at‑risk populations
  • Travel to endemic regions with serogroup C risk: provides prophylactic protection against invasive disease

How It Works

  • Menjugate contains polysaccharide from N. meningitidis group C covalently linked to the diphtheria toxoid CRM197. This conjugation converts the polysaccharide into a T‑cell‑dependent antigen, prompting the immune system to produce high‑affinity anti‑capsular antibodies and generate immunologic memory, thereby providing active protection against serogroup C meningococcal infection.

Side Effects

The following adverse reactions have been reported after administration of Menjugate.

Common Side Effects

  • Injection site pain
  • Redness or swelling at injection site
  • Fever
  • Headache
  • Fatigue
  • Muscle aches

Serious or Rare Side Effects

  • Anaphylaxis or severe allergic reaction
  • Guillain‑Barré syndrome (very rare)
  • High‑grade fever (>40 °C)
  • Seizures
  • Hypotension

Precautions & Warnings

Before administering Menjugate, consider the following precautions.

  • Allergy assessment: avoid use in individuals with a severe hypersensitivity to any vaccine component
  • Pregnancy: administer only if the potential benefit justifies the potential risk, as data are limited
  • Immunocompromised patients: vaccine may elicit a reduced immune response
  • Age‑specific schedule: follow approved dosing intervals for infants, children, adolescents and adults
  • Concurrent vaccinations: can be given with other vaccines at separate sites, but observe recommended intervals for live vaccines
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake

Avoid Interactions

Vaccine interactions are generally limited, but the following should be considered.

Major Interactions (Avoid)

  • Live attenuated vaccines: avoid simultaneous administration; separate by at least 4 weeks
  • Blood products containing immunoglobulins: may interfere with immune response if given concurrently

Moderate Interactions (Monitor Closely)

  • Immunosuppressive therapy: may diminish vaccine efficacy
  • Antipyretics: may mask fever, but generally acceptable
  • Other injectable vaccines: monitor for additive local reactions

Frequently Asked Questions

Menjugate is a conjugate vaccine indicated for the prevention of invasive disease caused by Neisseria meningitidis serogroup C. It is used in infants, children, adolescents and adults to protect against meningitis, septicemia and other serious infections associated with this bacterial strain.

The active ingredient is a polysaccharide from N. meningitidis group C linked to the diphtheria toxoid CRM197. This conjugation creates a T‑cell‑dependent antigen that stimulates the immune system to produce high‑affinity anti‑capsular antibodies and develop immunologic memory, providing active protection against serogroup C infection.

The dosing schedule for Menjugate is determined by the prescribing health professional based on age, previous vaccination history and local immunization guidelines. The prescriber selects the appropriate number of doses and intervals to achieve optimal protection.

Data on Menjugate use in pregnancy are limited. It should be administered only if the potential benefit to the mother outweighs any possible risk to the fetus. Breastfeeding is not a contraindication, but the decision should be made in consultation with a health‑care provider.

To order Menjugate, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.

Menjugate is a conjugate vaccine that uses the CRM197 carrier protein, similar to other licensed group C conjugates such as Menactra or Menveo. All provide T‑cell‑dependent immunity, but differences may exist in dosing schedules, carrier proteins and regional licensing. Clinical efficacy is comparable when administered according to approved regimens.

Menjugate must be stored at 2 °C to 8 °C (refrigerated). Keep the vials in the original packaging, protect them from light, and avoid freezing or shaking. Do not use the product if it has been exposed to temperatures outside this range.

Menjugate is given by intramuscular injection, typically into the deltoid muscle of the upper arm. The exact schedule (number of doses and intervals) is defined by national immunization programs and the prescribing clinician, with booster doses recommended for certain age groups.

The most serious adverse events reported are severe allergic reactions such as anaphylaxis, Guillain‑Barré syndrome (very rare), high‑grade fever, seizures and hypotension. Any signs of a severe reaction require immediate medical attention.

Menjugate should not be given to individuals with a known severe hypersensitivity to any component of the vaccine, including the CRM197 carrier protein. Persons who have experienced a previous severe allergic reaction to a meningococcal conjugate vaccine should also avoid it.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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