Product image of Menofem (Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent) supplied by GNH India

Menofem

Active Ingredient:
Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent
Origin:
EU

Menofem (Dry Extract From Cimicifuga Racemosa (L.) Nutt., Rhizoma (Black Cohosh) (5-10:1), Extraction Solvent)

Cimicifuga racemosa (black cohosh) dry extract, the active ingredient in Menofem, is an herbal preparation presented as a standardized dry extract for oral administration. It is intended to support women experiencing menopausal symptoms, including hot flashes and night sweats, by addressing hormonal fluctuation‑related discomfort.

GNH India supplies Menofem as a licensed, Good Distribution Practice‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide under appropriate regulatory frameworks. The company ensures batch consistency, quality testing, and adherence to EU‑origin standards for herbal medicines.

Manufacturer / TM Owner

Bionorica Se

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Indications & Clinical Uses

Menofem, a black cohosh dry extract, is used in the management of menopausal symptomatology.

  • Menopausal symptoms: helps alleviate overall discomfort associated with menopause.
  • Hot flashes: reduces frequency and intensity of vasomotor episodes.
  • Night sweats: decreases excessive nocturnal sweating.

How It Works

  • The precise mechanism of black cohosh dry extract is not fully defined. It is believed to modulate central neurotransmitters such as serotonin and dopamine and to exhibit weak estrogenic activity, influencing hypothalamic thermoregulatory centers that control vasomotor symptoms. It may also affect peripheral receptors that regulate vascular tone, helping to balance hormonal fluctuations without directly binding estrogen receptors in women.

Side Effects

Menofem may be associated with a range of adverse reactions, which are generally mild but can vary among individuals.

Common Side Effects

  • Gastrointestinal discomfort: mild nausea, abdominal cramps or diarrhea.
  • Headache: transient mild headache.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Liver enzyme elevation: signs of hepatic stress.
  • Severe allergic reaction: anaphylaxis or angioedema.
  • Unexpected uterine bleeding: abnormal menstrual‑type bleeding.

Precautions & Warnings

When considering Menofem, certain precautions and warnings should be observed to ensure safe use.

  • Medical review: assess underlying health conditions before initiating therapy.
  • Pregnancy: avoid use during pregnancy due to insufficient safety data.
  • Breastfeeding: discontinue if nursing, as transfer to milk is unknown.
  • Liver disease: monitor hepatic function in patients with existing liver conditions.
  • Drug interactions: consult healthcare professional regarding concurrent herbal or prescription medicines.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Menofem can interact with other substances; awareness of potential interactions helps minimize risk.

Major Interactions (Avoid)

  • Hormone replacement therapy: may amplify estrogenic effects, increasing risk of side effects.
  • Anticoagulants: possible increased bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): may enhance serotonergic activity, leading to serotonin syndrome.
  • CYP450 substrates: black cohosh may affect metabolism of drugs processed by CYP3A4.
  • Diuretics: potential additive effect on electrolyte balance.

Frequently Asked Questions

Menofem contains black cohosh dry extract, used to help manage menopausal symptoms such as hot flashes, night sweats and general discomfort associated with hormonal changes in women. It is an OTC herbal supplement taken orally under guidance of a healthcare professional.

The exact mechanism is not fully defined, but black cohosh is thought to modulate central neurotransmitters like serotonin and dopamine, exhibit weak estrogenic activity, and influence hypothalamic thermoregulatory centers, thereby reducing vasomotor symptoms. It may also affect peripheral vascular receptors, helping balance hormonal fluctuations without directly binding estrogen receptors.

The appropriate dose of Menofem is determined by the prescribing healthcare professional based on individual needs, product formulation and local regulatory guidance. Patients should follow the dosage instructions provided on the label or by their clinician and should not adjust the amount without medical advice.

Safety of black cohosh during pregnancy and lactation has not been established. Because of limited data, Menofem is generally not recommended for pregnant or breastfeeding women. Consultation with a physician is essential before use in these populations.

To place an order, submit an enquiry on the Menofem product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Menofem is an herbal, non‑hormonal option that may alleviate vasomotor symptoms without delivering systemic estrogen, whereas hormone replacement therapy provides estrogen (with or without progesterone) to replace declining hormones. HRT is more potent but carries different risk profiles; Menofem may be preferred by women seeking a botanical alternative or who cannot use HRT.

Menofem should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture, heat and direct sunlight. Keeping the product in a dry, cool place helps maintain its potency and shelf‑life.

Menofem is taken orally, typically as a tablet or capsule, according to the dosage instructions supplied by the prescriber or printed on the label. It should be swallowed with water and may be taken with or without food, unless otherwise directed by a healthcare professional.

Although uncommon, serious adverse reactions can include liver enzyme elevations indicating hepatic stress, severe allergic responses such as anaphylaxis or angioedema, and unexpected uterine bleeding. Patients should seek immediate medical attention if they experience signs of liver dysfunction, severe rash, swelling, or abnormal bleeding.

Menofem is not recommended for women who are pregnant, breastfeeding, have known liver disease, or have a history of allergic reactions to black cohosh. Individuals taking anticoagulants, hormone replacement therapy or other medications that may interact should consult their physician before starting Menofem.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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