Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotropin, the active ingredient in Menopur, is a gonadotropin presented as an injection solution for intramuscular or subcutaneous use. It provides exogenous FSH and LH activity to stimulate ovarian follicular development and estrogen production, supporting ovulation in women with infertility and assisting reproductive techniques such as IVF. The medication is prescribed by fertility specialists and administered under clinical monitoring.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, fertility clinics and pharmacies worldwide. Our distribution network ensures product integrity and regulatory compliance across regions.

Manufacturer / TM Owner

Ferring Gmbh

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Indications & Clinical Uses

Menopur (menotropin) is used in reproductive hormone therapy to stimulate ovarian function.

  • Infertility due to anovulation: enhances follicular growth to enable ovulation.
  • Controlled ovarian stimulation for assisted reproductive technology (e.g., IVF): provides coordinated FSH/LH activity to produce multiple mature oocytes.
  • Hypogonadotropic hypogonadism: replaces deficient gonadotropins to restore normal ovarian hormone production.

How It Works

  • Menotropin is a purified preparation containing both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. After subcutaneous or intramuscular injection, the FSH component binds to FSH receptors on granulosa cells, promoting follicular proliferation and estradiol synthesis. The LH component activates LH receptors on theca cells and mature follicles, supporting androgen production and final oocyte maturation, thereby facilitating ovulation.

Side Effects

Menopur may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Injection site pain: mild discomfort or bruising at the injection site.
  • Abdominal bloating: transient abdominal distension.
  • Nausea: occasional nausea.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (OHSS): severe ovarian enlargement with fluid shift.
  • Thromboembolic events: rare blood clot formation.
  • Allergic reaction: rash, urticaria, or anaphylaxis.

Precautions & Warnings

When using Menopur, specific precautions should be observed to minimize risks and ensure optimal outcomes.

  • Patient selection: assess ovarian reserve and risk factors for OHSS before initiating therapy.
  • Monitoring: perform regular ultrasound and estradiol measurements during stimulation.
  • Dose adjustment: modify dose based on response and any signs of excessive stimulation.
  • Contraindications: avoid use in active ovarian cysts, uncontrolled thyroid disease, or estrogen‑dependent tumors.
  • Pregnancy testing: confirm absence of pregnancy before starting treatment.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other medicines or substances that affect hormonal balance or coagulation.

Major Interactions (Avoid)

  • GnRH agonists/antagonists: concurrent use may alter stimulation protocols and increase OHSS risk.
  • Anticoagulants: heightened risk of bleeding if severe OHSS develops.

Moderate Interactions (Monitor Closely)

  • Thyroid hormones: adjust levothyroxine dose as estradiol changes can affect thyroid binding.
  • Steroids: may mask ovarian response assessments.
  • Diuretics: can influence fluid balance during OHSS.

Frequently Asked Questions

Menopur is prescribed to treat infertility caused by anovulation, to support controlled ovarian stimulation in assisted reproductive technologies such as in‑vitro fertilisation, and to replace deficient gonadotropins in women with hypogonadotropic hypogonadism.

Menotropin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH). After injection, FSH stimulates granulosa cells to grow and produce estrogen, while LH activates theca cells and mature follicles, promoting androgen conversion and final oocyte maturation, thereby facilitating ovulation.

The dose of Menopur is individualized. A qualified fertility specialist determines the amount and frequency based on the patient’s ovarian reserve, response to previous cycles, and the specific assisted‑reproduction protocol.

Menopur is intended for use before conception to induce ovulation. Its safety in an established pregnancy or during breastfeeding has not been established, and it should only be used under the guidance of a reproductive specialist.

To order Menopur, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling) and required import documentation.

The primary alternative to Menopur is recombinant FSH/LH preparations. Menopur is a purified urinary‑derived gonadotropin containing both FSH and LH activity in a fixed ratio, whereas recombinant products are individually manufactured and can be dosed separately. Clinical outcomes are comparable, but choice often depends on physician preference, cost and patient response.

Menopur must be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. If the product reaches room temperature for a short period, it may still be used, but it should be returned to refrigeration promptly.

Menopur is administered by a healthcare professional as an intramuscular or subcutaneous injection. The injection site is typically the abdomen or thigh, and the exact technique, volume and timing are determined by the treating physician as part of the ovarian stimulation protocol.

The most serious risks associated with Menopur include ovarian hyperstimulation syndrome (OHSS), which can cause severe ovarian enlargement and fluid shifts, thromboembolic events such as blood clots, and rare allergic reactions that may progress to anaphylaxis. Prompt medical attention is required if any of these occur.

Menopur is contraindicated in women with active ovarian cysts, uncontrolled thyroid disease, estrogen‑dependent tumors, severe ovarian hyperstimulation syndrome, or known hypersensitivity to menotropin or any excipients. It should also be avoided in patients who are already pregnant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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