Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotrophin, the active ingredient in Menopur, is a Gonadotropin (FSH/LH) preparation presented as an injectable solution for intramuscular or subcutaneous use. It provides exogenous FSH and LH activity to stimulate follicular development and ovulation in women undergoing fertility treatment.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to strict quality standards and offers reliable cold‑chain logistics for biologic products. Our distribution network ensures timely delivery to reproductive medicine centres across Europe, Asia and the Americas.

Manufacturer / TM Owner

Ferring Hellas Mepe

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Indications & Clinical Uses

Menopur is used in reproductive medicine to support ovarian stimulation and ovulation induction.

  • Infertility due to anovulation: stimulates follicular development to promote ovulation in women with anovulatory infertility.
  • Assisted reproductive technology (ART) stimulation: enhances follicle growth to increase the number of oocytes retrieved for IVF or ICSI cycles.
  • Controlled ovarian hyperstimulation: provides controlled FSH/LH activity to achieve optimal ovarian response during fertility treatment protocols.

How It Works

  • Menotrophin contains both follicle‑stimulating hormone (FSH) and luteinising hormone (LH) activity. After subcutaneous or intramuscular injection, the hormones bind to their respective receptors on ovarian granulosa and theca cells, activating intracellular signaling pathways that promote follicular maturation, estradiol synthesis, and final oocyte release during the ovulatory phase.

Side Effects

Menopur may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Injection site pain or erythema: mild discomfort at the administration site.
  • Abdominal bloating: transient abdominal distension following stimulation.
  • Headache: mild to moderate intensity.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (OHSS): potentially severe fluid shift and thromboembolic risk.
  • Multiple pregnancy: increased likelihood of twins or higher-order gestations.
  • Allergic reaction: rash, urticaria, or anaphylaxis in rare cases.

Precautions & Warnings

When prescribing Menopur, clinicians should observe several precautionary measures to optimise safety and efficacy.

  • Monitor ovarian response: use ultrasound and estradiol levels to adjust dosing.
  • Assess thyroid function: avoid use in uncontrolled thyroid disease.
  • Evaluate for hypersensitivity: discontinue if allergic signs appear.
  • Caution with ovarian cysts: consider alternative protocols if cysts are present.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other medications, influencing ovarian response or increasing risk of complications.

Major Interactions (Avoid)

  • GnRH agonist therapy: may amplify ovarian response and raise OHSS risk.
  • Estrogen‑containing medications: can alter follicular dynamics and reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may suppress endogenous gonadotropins, requiring careful timing.
  • Thyroid hormone therapy: monitor thyroid status as it can affect ovarian sensitivity.
  • Corticosteroids: may modify ovarian response and require dose adjustment.

Frequently Asked Questions

Menopur is a gonadotropin preparation used in reproductive medicine to stimulate follicular development and induce ovulation in women undergoing fertility treatment, including anovulatory infertility, assisted reproductive technology cycles, and controlled ovarian hyperstimulation protocols.

Menotrophin contains both FSH and LH activity. After injection, the hormones bind to their specific ovarian receptors, activating signaling pathways that promote granulosa and theca cell proliferation, estradiol production, and maturation of ovarian follicles leading to ovulation.

The dose of Menopur is individualized. A qualified prescriber determines the amount, frequency, and duration based on the patient’s ovarian response, treatment protocol, and monitoring results. Exact dosing regimens are not standardized and must follow clinical guidance.

Menopur is not intended for use during an established pregnancy and its safety in pregnancy has not been established. Women should avoid conception until treatment is completed and a negative pregnancy test is confirmed. Limited data exist for breastfeeding, so caution is advised and consultation with a healthcare professional is recommended.

To order Menopur, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics) and necessary import documentation.

Menopur is a urinary‑derived gonadotropin containing both FSH and LH activity, whereas many alternatives are recombinant FSH‑only preparations. The combined activity can be advantageous in certain protocols, but dosing flexibility and purity differ. Choice of product depends on clinician preference, patient response, and specific treatment goals.

Menopur must be stored refrigerated at 2‑8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. Once reconstituted, use the solution promptly according to the manufacturer’s instructions and discard any unused portion after the recommended time.

Menopur is supplied as an injectable solution for subcutaneous or intramuscular injection. The vial is reconstituted with the appropriate diluent, drawn into a sterile syringe, and administered according to the dosing schedule prescribed by the treating physician, typically once daily during the stimulation phase.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can cause severe abdominal pain, fluid accumulation, and thromboembolic events; multiple pregnancy, increasing obstetric complications; and rare allergic reactions such as anaphylaxis. Patients should be monitored closely for these complications.

Menopur is contraindicated in individuals with known hypersensitivity to menotrophin or any excipients, in women who are already pregnant, and in patients with uncontrolled thyroid disease, active ovarian cysts, or severe ovarian failure. Caution is also advised for those with a history of severe OHSS.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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