Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotrophin, the active ingredient in Menopur, is a gonadotropin presented as an injectable solution for intramuscular or subcutaneous use. It provides follicle‑stimulating and luteinizing hormone activity to treat infertility in women and stimulate spermatogenesis in men with hypogonadotropic hypogonadism.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across global markets. The company provides dedicated logistics, cold‑chain management where required, and comprehensive documentation to support import and distribution.

Manufacturer / TM Owner

Ferring Lægemidler A/S

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Indications & Clinical Uses

Menopur is a gonadotropin used in reproductive medicine to stimulate follicular development and hormone production.

  • Anovulatory women: induces ovulation by providing exogenous FSH and LH activity, enhancing the likelihood of natural conception.
  • Assisted reproductive technology cycles (IVF, ICSI): promotes development of multiple ovarian follicles, facilitating controlled ovarian hyperstimulation and optimal egg retrieval.
  • Men with hypogonadotropic hypogonadism: stimulates testicular Leydig and Sertoli cell function to increase spermatogenesis and improve male fertility outcomes.

How It Works

  • Menotrophin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) molecular components that bind to their respective receptors on ovarian granulosa cells and testicular Leydig/Sertoli cells. Activation of these receptors triggers intracellular signaling cascades that promote follicular growth, estrogen synthesis, and, in men, testosterone production and spermatogenic activity, thereby supporting the reproductive axis.

Side Effects

Menopur may be associated with a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Injection site pain or erythema: mild discomfort or redness at the injection site.
  • Abdominal discomfort or bloating: transient gastrointestinal upset.
  • Headache: mild to moderate intensity.
  • Nausea: occasional feeling of queasiness.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (OHSS): potentially severe fluid shift and ovarian enlargement.
  • Multiple pregnancy: increased risk of twins or higher-order gestations.
  • Severe allergic reaction (anaphylaxis): rare but may include rash, swelling, and respiratory distress.

Precautions & Warnings

When using Menopur, clinicians should observe several precautionary measures to minimize risks and optimize treatment outcomes.

  • Monitor ovarian response: perform serial ultrasounds and estradiol measurements to detect excessive stimulation.
  • Risk of OHSS: assess patient risk factors and adjust dose or discontinue if signs appear.
  • Contraindicated in pregnancy: avoid use in confirmed pregnancy.
  • Hormone‑sensitive tumors: do not use in patients with estrogen‑dependent neoplasms.
  • Thyroid disease: correct underlying thyroid dysfunction before initiating therapy.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other medications that affect hormonal balance or coagulation, requiring careful management.

Major Interactions (Avoid)

  • GnRH agonists: may blunt the intended gonadotropin response.
  • Oral contraceptives: suppress endogenous gonadotropins, reducing efficacy.
  • Chemotherapy agents: can impair gonadal function and counteract treatment goals.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone therapy: may alter ovarian response; monitor thyroid levels.
  • Anticoagulants: increased risk of ovarian cyst rupture; observe for bleeding.
  • Corticosteroids: may affect hormone metabolism; adjust monitoring as needed.

Frequently Asked Questions

Menopur is prescribed to induce ovulation in women who do not ovulate spontaneously, to stimulate multiple follicle development during assisted reproductive technology cycles such as IVF or ICSI, and to treat hypogonadotropic hypogonadism in men by promoting spermatogenesis.

Menotrophin provides both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. These hormones bind to receptors on ovarian and testicular cells, triggering signaling pathways that promote follicular growth, estrogen and testosterone production, and ultimately support gamete development.

The dose of Menopur is individualized for each patient. A qualified prescriber determines the amount, frequency, and duration of therapy based on the specific indication, patient response, and monitoring results.

Menopur is not indicated for use during an established pregnancy and should be avoided. Limited data exist for breastfeeding; therefore, the medication is generally not recommended while nursing without a risk‑benefit assessment by the treating physician.

To order Menopur, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Menopur contains both FSH and LH activity, whereas many recombinant preparations provide only FSH. This dual activity can be advantageous in certain protocols, but recombinant FSH products may offer more precise dosing and lower risk of antibody formation. Choice depends on clinical protocol, patient characteristics, and physician preference.

Menopur should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Keep the product in its original packaging until use and discard any solution that appears discolored or contains particles.

Menopur is supplied as a sterile injectable solution. It is administered by a trained healthcare professional via intramuscular or subcutaneous injection, typically after reconstitution according to the package insert. Injection sites are rotated to reduce local irritation.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can cause severe abdominal pain and fluid shifts, multiple pregnancy, and rare severe allergic reactions such as anaphylaxis. Patients should be monitored closely for early signs of these conditions.

Menopur is contraindicated in patients with known hypersensitivity to menotropin or any excipients, in confirmed pregnancy, in individuals with hormone‑sensitive tumors, and in those with uncontrolled thyroid disease or severe ovarian cysts. Clinicians should assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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