Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotropin, the active ingredient in Menopur, is a human menopausal gonadotropin presented as an injectable solution for intramuscular or subcutaneous use. It treats infertility due to anovulation, supports ovarian stimulation for assisted reproductive technology, and addresses hypogonadotropic hypogonadism in males.

GNH India supplies Menopur as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ferring Ireland Ltd.

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Indications & Clinical Uses

Menotropin (Menopur) is used in reproductive hormone therapy to stimulate gonadal function.

  • Anovulatory infertility: promotes follicular development to enable ovulation.
  • Assisted reproductive technology (IVF): enhances ovarian response to retrieve multiple oocytes.
  • Male hypogonadotropic hypogonadism: stimulates testicular testosterone production and spermatogenesis.

How It Works

  • Menotropin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. The FSH component binds to FSH receptors on ovarian granulosa cells, stimulating follicle growth and estrogen synthesis, while the LH component activates LH receptors on theca and Leydig cells, supporting steroidogenesis, ovulation, and testosterone production in males.

Side Effects

Menopur may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Injection site pain or redness.
  • Abdominal discomfort or bloating.
  • Headache.
  • Nausea.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome, potentially severe.
  • Multiple pregnancy.
  • Allergic reaction or anaphylaxis.
  • Thromboembolic events or severe abdominal pain.

Precautions & Warnings

When using Menopur, several precautions should be observed to minimize risks.

  • Monitor ovarian response: adjust dose based on ultrasound and estradiol levels.
  • Assess OHSS risk: evaluate patient history and limit stimulation in high‑risk individuals.
  • Review thyroid function: gonadotropins may affect thyroid hormone metabolism.
  • Check for allergies: avoid use in patients with known hypersensitivity to menotropin or related proteins.
  • Use caution in cancer patients: consider potential effects on hormone‑sensitive tumors.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other medications, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Concurrent use of other gonadotropins: may cause excessive ovarian response.
  • High‑dose estrogen therapy: can blunt the intended stimulation effect.
  • Use with ovarian stimulation protocols that predispose to OHSS: increases severe syndrome risk.
  • Certain chemotherapy agents: may interfere with hormonal balance.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: may alter follicular development response.
  • Anticoagulants: increased bleeding risk if ovarian cysts rupture.
  • Thyroid hormone replacement: may require dose adjustments.
  • Antipsychotic medications: potential impact on prolactin levels.

Frequently Asked Questions

Menopur is prescribed to treat infertility caused by anovulation, to stimulate the ovaries during assisted reproductive technologies such as in‑vitro fertilisation, and to manage hypogonadotropic hypogonadism in men by promoting testosterone production and spermatogenesis.

Menotropin provides both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. FSH drives growth of ovarian follicles and estrogen synthesis, while LH supports steroid production, ovulation, and, in males, testosterone synthesis by Leydig cells, thereby enhancing reproductive potential.

The dose of Menopur is individualized. A qualified prescriber determines the amount, frequency, and duration based on the patient’s clinical response, ovarian monitoring results, and the specific assisted‑reproduction protocol being used.

Menopur is not indicated for use during pregnancy, and its safety for the mother or fetus has not been established. Breastfeeding considerations should be discussed with a healthcare professional, as the drug may affect milk production or infant exposure.

To order Menopur, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Menopur is a purified human menopausal gonadotropin containing both FSH and LH activity, whereas many newer agents are recombinant FSH only. The combined activity can be advantageous for certain protocols, but dosing may differ and some clinicians prefer recombinant products for their consistency and lower risk of antibody formation.

Menopur should be stored at 2‑8 °C in a refrigerator, protected from light. It must not be frozen or shaken. After reconstitution, the solution should be used promptly according to the prescribing information and any remaining product discarded if not used within the recommended time.

Menopur is supplied as a sterile injectable solution for intramuscular or subcutaneous injection. The vial is reconstituted with the appropriate diluent, and the dose is drawn into a sterile syringe. Administration technique and injection site are determined by the treating physician.

The most serious risks associated with Menopur include ovarian hyperstimulation syndrome (OHSS), which can be severe and life‑threatening, multiple gestation pregnancies, and rare allergic reactions such as anaphylaxis. Patients should be monitored closely for abdominal pain, rapid weight gain, shortness of breath, or signs of allergic response.

Menopur is contraindicated in individuals with known hypersensitivity to menotropin or any component of the formulation, in patients with ovarian cysts or tumors, in those with uncontrolled thyroid disease, and in patients with active hormone‑sensitive cancers. Use should also be avoided in pregnancy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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