Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotrophin, the active ingredient in Menopur, is a gonadotropin presented as an injectable solution for intramuscular or subcutaneous use. It treats infertility due to anovulation and is employed in assisted reproductive technology protocols to stimulate ovarian follicular development. By providing both follicle‑stimulating hormone (FSH) and luteinising hormone (LH) activity, it promotes the growth and maturation of ovarian follicles.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide through regulated distribution channels that ensure product integrity.

Manufacturer / TM Owner

Ferring Gmbh

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Indications & Clinical Uses

  • Menopur is a gonadotropin used in fertility treatment to stimulate ovarian function.
  • Infertility due to anovulation: promotes follicular development to enable ovulation.
  • Assisted reproductive technology (ART) protocols: supports controlled ovarian hyperstimulation for procedures such as in‑vitro fertilisation.
  • Ovarian stimulation for IVF cycles: enhances the number of mature oocytes retrieved.
  • Multiple follicle development in donor cycles: increases oocyte yield for egg donation programs.

How It Works

  • Menotrophin contains both follicle‑stimulating hormone (FSH) and luteinising hormone (LH) activity. The FSH component binds to receptors on granulosa cells, stimulating proliferation and estradiol synthesis, while the LH component activates receptors on theca cells, promoting androgen production that serves as substrate for estrogen formation. The combined action enhances follicular growth, maturation, and ovulation, facilitating oocyte retrieval in assisted reproductive procedures.

Side Effects

Menopur may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

  • Injection site reactions: pain, redness or swelling at the injection site.
  • Abdominal discomfort: bloating or mild pelvic pain.
  • Nausea: occasional feeling of sickness.

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome (OHSS): can lead to fluid accumulation, thrombosis, or renal impairment.
  • Multiple pregnancy: increased risk of twins or higher-order gestations.
  • Allergic reaction (anaphylaxis): rare but potentially life‑threatening hypersensitivity.

Precautions & Warnings

When using Menopur, careful monitoring and specific safety measures are recommended.

  • Monitor ovarian response: perform serial ultrasounds and hormone assays to adjust dose.
  • Assess risk of OHSS: evaluate patient history and baseline estradiol levels.
  • Use under specialist supervision: treatment should be managed by reproductive endocrinologists.
  • Avoid in uncontrolled thyroid disease or hormone‑dependent tumors.
  • Discontinue if severe OHSS develops.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other medicines, requiring attention to avoid or monitor effects.

Major Interactions (Avoid)

  • Concurrent use of other gonadotropins: may cause excessive ovarian stimulation.
  • Co‑administration with GnRH agonists in high doses: increases risk of severe OHSS.
  • Estrogen‑containing therapies: can alter response to Menopur.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: may affect follicular development, monitor response.
  • Anticoagulants: increased risk of injection‑site bleeding.
  • Thyroid hormone therapy: may modify ovarian response.

Frequently Asked Questions

Menopur, containing menotrophin, is used in fertility treatment to stimulate ovarian follicular development in women with anovulation and in assisted reproductive technology protocols such as in‑vitro fertilisation. It helps induce ovulation and increase the number of mature oocytes available for retrieval.

Menotrophin provides both follicle‑stimulating hormone (FSH) and luteinising hormone (LH) activity. FSH binds to receptors on granulosa cells, promoting cell proliferation and estradiol production, while LH activates receptors on theca cells, stimulating androgen synthesis that is converted to estrogen. The combined effect supports follicle growth, maturation and ovulation.

The dose of Menopur is individualized; a prescribing physician determines the amount and schedule based on the patient’s ovarian response, treatment protocol, and clinical monitoring. Dosage adjustments are made according to ultrasound findings and hormone levels, and the regimen may vary between cycles.

Menopur is intended for use before conception to induce ovulation; its safety in established pregnancy has not been established, and it is generally not recommended during pregnancy. Limited data exist for breastfeeding, and the product should be used only if the potential benefit justifies any possible risk to the infant.

To order Menopur, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling) and the necessary import documentation.

Menopur contains both FSH and LH activity in a single preparation, whereas some alternatives provide only FSH (e.g., follitropin alfa) or separate LH preparations. This combined profile can simplify dosing for protocols that require both hormones, but the choice of product depends on individual patient response, protocol design and physician preference.

Menopur must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Vials should remain in the original packaging until use, and any unused portion should be discarded according to local regulations after the recommended storage period.

Menopur is supplied as an injectable solution for intramuscular or subcutaneous injection. The medication is reconstituted with the appropriate diluent, drawn into a sterile syringe, and administered according to the prescribing clinician’s instructions, typically in a clinical setting or under supervised self‑administration.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can range from mild to severe and may cause abdominal pain, fluid accumulation, thrombosis or renal impairment, as well as the possibility of multiple pregnancy and rare allergic reactions such as anaphylaxis. Close monitoring during treatment is essential.

Menopur is contraindicated in women with uncontrolled thyroid disease, ovarian cysts, active hormone‑dependent tumors, severe ovarian hyperstimulation syndrome, or known hypersensitivity to menotrophin or any excipients. It should also be avoided in individuals for whom ovarian stimulation is not indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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