Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotrophin, the active ingredient in Menopur, is a gonadotropin (FSH/LH) presented as an injectable solution for intramuscular or subcutaneous use. It provides exogenous FSH and LH activity to stimulate follicular development and ovulation in women and to support spermatogenesis in men with specific infertility conditions.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable cold‑chain logistics for biologic products, including regulatory support for import and export.

Manufacturer / TM Owner

Ferring Ireland Ltd.

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Indications & Clinical Uses

  • Menopur, a gonadotropin used in reproductive medicine, is indicated for several infertility‑related conditions.
  • Infertility due to anovulation: promotes follicular growth to enable ovulation in women who do not ovulate spontaneously.
  • Controlled ovarian stimulation for IVF/ICSI: supports multiple follicle development to retrieve oocytes for assisted reproductive technologies.
  • Induction of ovulation in hypogonadotropic hypogonadism: replaces deficient gonadotropins to trigger ovulation in women with low endogenous FSH/LH.
  • Stimulation of spermatogenesis in hypogonadotropic hypogonadism: provides LH and FSH activity to encourage sperm production in affected men.

How It Works

  • Menotrophin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. The FSH component binds to FSH receptors on ovarian granulosa cells, stimulating estrogen production and follicular maturation, while the LH component activates LH receptors on theca cells and Leydig cells, promoting androgen synthesis and ovulation in women and testosterone production for spermatogenesis in men.

Side Effects

Menopur may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Abdominal discomfort or bloating
  • Injection site pain or erythema
  • Mild ovarian hyperstimulation symptoms such as mild abdominal pain
  • Headache or nausea

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (severe) leading to fluid accumulation and organ dysfunction
  • Multiple pregnancy (twins or higher order)
  • Thromboembolic events or severe allergic reactions including anaphylaxis

Precautions & Warnings

  • When prescribing Menopur, clinicians should observe the following precautions.
  • Monitor ovarian response: use ultrasound and estradiol measurements to adjust dosing and reduce risk of hyperstimulation.
  • Avoid use in pregnancy: Menopur is not indicated for treatment during pregnancy and should be discontinued if pregnancy occurs.
  • Assess for hypersensitivity: discontinue immediately if signs of allergic reaction such as rash, itching, or swelling appear.
  • Consider risk of multiple gestation: counsel patients about the increased chance of twins or higher-order pregnancies.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other medications; notable interactions are categorized by clinical significance.

Major Interactions (Avoid)

  • GnRH agonists: may amplify ovarian response and increase risk of severe hyperstimulation.
  • Hormonal contraceptives: can blunt the intended ovulatory effect of Menopur.
  • Anticoagulants: heightened risk of bleeding if severe ovarian hyperstimulation occurs.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone therapy: may alter the hormonal milieu and affect response.
  • Corticosteroids: can influence endogenous hormone levels and modify treatment outcomes.

Frequently Asked Questions

Menopur is a gonadotropin preparation used to treat infertility. It helps women who do not ovulate spontaneously achieve follicular development and ovulation, supports controlled ovarian stimulation for assisted reproductive technologies such as IVF or ICSI, and can stimulate spermatogenesis in men with hypogonadotropic hypogonadism.

Menotrophin contains both FSH and LH activity. The FSH component binds to receptors on ovarian granulosa cells, promoting estrogen production and follicle growth, while the LH component activates receptors on theca and Leydig cells, stimulating androgen synthesis, ovulation in women, and testosterone‑dependent sperm production in men.

The dose of Menopur is individualized. A qualified prescriber determines the amount, frequency, and duration of treatment based on the patient’s specific diagnosis, response to therapy, and monitoring results such as ultrasound and hormone levels.

Menopur is not intended for use during an established pregnancy and should be stopped if pregnancy occurs. Safety data for breastfeeding are limited, and the drug is generally avoided in lactating women unless the prescriber judges that the benefit outweighs potential risk.

To order Menopur, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling) and necessary import documentation.

Menopur provides a combined FSH and LH activity in a single preparation, whereas some alternatives such as recombinant FSH (e.g., follitropin alfa) contain only FSH. The combined activity can simplify dosing for patients who need both hormones, but the choice depends on clinical response, physician preference and cost considerations.

Menopur should be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. Once reconstituted, follow the manufacturer’s guidance on stability and discard any unused portion after the recommended period.

Menopur is supplied as an injectable solution for intramuscular or subcutaneous injection. The prescriber prepares the dose according to the patient’s treatment plan and administers it using a sterile syringe, typically under clinical supervision or after appropriate patient training for self‑administration.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can be severe and lead to fluid shifts, thromboembolic events, and multiple gestation (twins or higher order pregnancies). Prompt monitoring of ovarian response and estradiol levels helps mitigate these risks.

Menopur is contraindicated in individuals with known hypersensitivity to menotrophin or any component of the formulation, in women who are already pregnant, and in patients with uncontrolled thyroid disease, ovarian cysts, or severe ovarian failure where stimulation would be ineffective.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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