Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotropin, the active ingredient in Menopur, is a gonadotropin presented as a lyophilized powder for injection use. It provides combined FSH and LH activity to stimulate ovarian follicular development and estrogen production, and is employed in the treatment of infertility caused by anovulation and in ovarian stimulation for assisted reproductive technologies.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, fertility clinics and pharmacies worldwide, ensuring quality‑controlled product handling and regulatory compliance to global distribution.

Manufacturer / TM Owner

Ferring S.A.U.

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Indications & Clinical Uses

  • Menopur, a gonadotropin used in reproductive endocrinology, is indicated for the following conditions:
  • Infertility due to anovulation: Facilitates follicular growth to enable ovulation and improve conception chances.
  • Ovarian stimulation for assisted reproductive technology (IVF, ICSI): Enhances multiple follicle development to increase the number of retrievable oocytes.
  • Induction of ovulation in hypogonadotropic hypogonadism: Replaces deficient endogenous gonadotropins to trigger ovulation in women with impaired hypothalamic‑pituitary function.

How It Works

  • Menotropin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. After subcutaneous or intramuscular injection, it binds to ovarian FSH and LH receptors, activating intracellular signaling pathways that promote granulosa cell proliferation, estrogen synthesis, and the final maturation of ovarian follicles, ultimately leading to ovulation.

Side Effects

Menopur may cause a range of adverse reactions. Monitoring and prompt reporting are essential.

Common Side Effects

  • Abdominal discomfort or bloating
  • Injection‑site pain, redness or swelling
  • Mild headache
  • Mild ovarian hyperstimulation syndrome (OHSS) presenting as mild abdominal distension
  • Nausea or mild vomiting

Serious or Rare Side Effects

  • Severe OHSS with rapid weight gain, shortness of breath, or pleural effusion
  • Multiple pregnancy (twins, triplets, etc.)
  • Allergic reactions such as rash, urticaria, or anaphylaxis
  • Thromboembolic events
  • Ectopic pregnancy

Precautions & Warnings

  • Before initiating Menopur therapy, clinicians should consider several safety measures.
  • Monitor ovarian response: Use serial ultrasound and estradiol measurements to adjust dosing.
  • Avoid use in active ovarian cysts: Presence of cysts increases risk of complications.
  • Assess for hypersensitivity: Discontinue if allergic signs appear.
  • Consider risk of multiple pregnancy: Counsel patients about the possibility of twins or higher-order gestations.
  • Adjust dose in renal or hepatic impairment: Reduced clearance may heighten adverse effects.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other agents that affect ovarian response or hemostasis.

Major Interactions (Avoid)

  • Concurrent use of other gonadotropins: May lead to excessive ovarian stimulation.
  • GnRH agonist therapy: Can amplify response and increase OHSS risk.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: May blunt the ovarian response to Menotropin.
  • Anticoagulants: Increased bleeding risk if ovarian cysts rupture.
  • Thyroid hormones: May alter hormone metabolism and affect treatment outcomes.

Frequently Asked Questions

Menopur is a gonadotropin preparation that provides both FSH and LH activity. It is used to treat infertility caused by anovulation, to stimulate the ovaries during assisted reproductive technologies such as IVF or ICSI, and to induce ovulation in women with hypogonadotropic hypogonadism.

Menotropin contains follicle‑stimulating hormone (FSH) and luteinizing hormone (LH). After injection, it binds to specific receptors on ovarian cells, triggering signaling pathways that promote follicle growth, estrogen production, and final maturation of the oocyte, thereby facilitating ovulation.

The dose of Menopur is individualized. A qualified prescriber determines the amount, frequency, and duration based on the patient’s ovarian response, underlying condition, and treatment protocol. Patients should follow the prescribing physician’s instructions and not alter the regimen on their own.

Menopur is intended for use before pregnancy to achieve conception. Its safety in established pregnancy or while breastfeeding has not been established, and it is generally not recommended for use during these periods. Women should discuss any concerns with their healthcare provider.

To order Menopur, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Menopur delivers a fixed combination of FSH and LH activity, whereas some alternatives provide only FSH (e.g., recombinant FSH) or separate LH preparations. The combined activity can simplify dosing for certain protocols, but clinicians choose the product based on individual patient response, cost, and specific treatment goals.

Menopur is supplied as a lyophilized powder for reconstitution. It must be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Once reconstituted, the solution should be used within the time frame specified in the product label and kept refrigerated if not used immediately.

Menopur is administered by subcutaneous or intramuscular injection after reconstitution with the supplied diluent. The injection site is typically the abdomen or thigh for subcutaneous use, or the gluteal muscle for intramuscular administration. Proper aseptic technique and dosing instructions from the prescriber must be followed.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can cause rapid weight gain, fluid accumulation, and respiratory distress, as well as multiple pregnancy and rare allergic reactions such as anaphylaxis. Patients should be monitored closely for early signs of these complications.

Menopur is contraindicated in individuals with known hypersensitivity to menotropin or any component of the formulation, in women with active ovarian cysts, uncontrolled thyroid disease, or severe ovarian hyperstimulation syndrome. It should also be avoided in patients for whom pregnancy is not desired without appropriate contraceptive measures.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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