Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotropin, the active ingredient in Menopur, is a gonadotropin (FSH/LH) preparation presented as a powder for solution for injection for subcutaneous use. It treats infertility by stimulating follicular development in anovulatory women and enhancing spermatogenesis in men with hypogonadotropic hypogonadism.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our global distribution network ensures consistent quality and regulatory compliance, enabling healthcare providers to access the product for reproductive medicine programs across Europe, Asia, Africa and the Americas.

Manufacturer / TM Owner

Ferring Lægemidler A/S

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Indications & Clinical Uses

Menopur is used in reproductive medicine to modulate gonadotropin pathways for infertility treatment.

  • Anovulatory infertility: induces ovulation in women who do not ovulate spontaneously, facilitating natural or assisted conception.
  • Assisted reproductive technology cycles: supports controlled ovarian hyperstimulation for in‑vitro fertilisation, ICSI and embryo transfer procedures.
  • Male hypogonadotropic hypogonadism: stimulates spermatogenesis in men with deficient FSH/LH production, improving sperm output.

How It Works

  • Menotropin contains both follicle‑stimulating hormone (FSH) and luteinising hormone (LH) activity. After subcutaneous injection, the FSH component binds to ovarian FSH receptors, promoting granulosa cell proliferation and follicular growth. The LH component engages LH receptors on theca cells, enhancing androgen production that is aromatised to estrogen, thereby supporting final follicular maturation and ovulation. In males, LH activity stimulates Leydig cells to produce testosterone, while FSH promotes Sertoli‑cell function and spermatogenesis.

Side Effects

Menopur may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Injection site pain: mild discomfort or erythema at the injection site.
  • Abdominal bloating: transient abdominal distension or discomfort.
  • Headache: mild to moderate headache episodes.
  • Ovarian hyperstimulation symptoms: mild abdominal discomfort, nausea, or mild weight gain.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (OHSS): severe ovarian enlargement, fluid shift, and thromboembolic risk.
  • Multiple pregnancy: increased chance of twins or higher-order gestations.
  • Allergic reaction: rash, urticaria, or anaphylaxis.

Precautions & Warnings

Prior to initiating Menopur, clinicians should evaluate patient history and monitor specific parameters to minimise risks.

  • Baseline ovarian assessment: perform ultrasound to determine follicle count and size.
  • Hormone monitoring: regularly measure serum estradiol and LH/FSH levels during treatment.
  • OHSS risk evaluation: assess risk factors such as polycystic ovary syndrome or high antral follicle count.
  • Pregnancy testing: confirm absence of pregnancy before starting therapy.
  • Concomitant medication review: avoid drugs that may exacerbate ovarian response or interact with gonadotropins.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other agents that affect hormonal balance or ovarian response.

Major Interactions (Avoid)

  • GnRH agonists/antagonists: concurrent use may cause excessive ovarian stimulation.
  • Aromatase inhibitors: may blunt estrogen response and reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Clomiphene citrate: combined use may increase risk of OHSS, requiring dose adjustment.
  • Anticoagulants: monitor for thrombotic events if OHSS develops.
  • Thyroid hormone therapy: ensure euthyroid status as thyroid imbalance can affect response.

Frequently Asked Questions

Menopur is a gonadotropin preparation used to treat infertility. It induces ovulation in women who do not ovulate spontaneously, supports controlled ovarian hyperstimulation for assisted reproductive technologies such as IVF, and stimulates spermatogenesis in men with hypogonadotropic hypogonadism.

Menotropin contains both FSH and LH activity. After subcutaneous injection, FSH binds to ovarian receptors to promote follicle growth, while LH stimulates androgen production that is converted to estrogen, completing follicular maturation. In men, LH drives testosterone production and FSH supports Sertoli‑cell function for sperm development.

The dose of Menopur is individualized. A qualified prescriber determines the amount, frequency and duration of treatment based on the patient’s specific condition, response to therapy and monitoring results. No standard dosing regimen is provided here.

Menopur is intended for use before pregnancy to achieve conception and is not indicated for use during pregnancy. Safety data for breastfeeding are lacking, so the product should be avoided in nursing mothers unless the prescriber decides otherwise.

To order Menopur, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Menopur provides both FSH and LH activity in a single preparation, whereas some alternatives contain only FSH (e.g., follitropin alfa) or require separate LH supplementation. This combined profile can simplify dosing for protocols that need both hormones, but the choice depends on individual patient response and clinician preference.

Menopur should be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and do not freeze or shake the product. Once reconstituted, use according to the manufacturer’s instructions and discard any unused solution after the recommended period.

Menopur is supplied as a powder for solution for injection. After reconstitution with the appropriate diluent, it is administered subcutaneously, usually in the abdominal wall or thigh, following the dosing schedule prescribed by the treating physician.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can cause severe abdominal pain, fluid accumulation and thromboembolic complications, and multiple pregnancy, which raises obstetric risks. Prompt medical evaluation is required if symptoms of OHSS or signs of multiple gestation appear.

Menopur is contraindicated in women with known hypersensitivity to menotropin or any excipients, in patients with ovarian cysts or tumors, and in individuals with uncontrolled thyroid disease or severe ovarian hyperstimulation risk. It should also be avoided in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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