Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotrophin, the active ingredient in Menopur, is a gonadotropin presented as a powder for solution for injection for subcutaneous use. It is employed to treat infertility caused by anovulation and to facilitate controlled ovarian stimulation in assisted reproductive technology cycles.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Customers benefit from consistent product integrity and responsive technical support throughout the supply chain.

Manufacturer / TM Owner

Ferring Lääkkeet Oy

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Indications & Clinical Uses

  • Menopur (menotrophin) is used in reproductive medicine to stimulate ovarian follicular development.
  • Infertility due to anovulation: promotes follicle growth to enable ovulation and increase the chance of conception.
  • Controlled ovarian stimulation for assisted reproductive technology: enhances multiple follicle development to improve egg retrieval outcomes in IVF cycles.
  • Ovulation induction for intrauterine insemination: supports follicular maturation to increase the likelihood of successful insemination.

How It Works

  • Menotrophin is a purified preparation containing both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. After subcutaneous injection, the FSH component binds to FSH receptors on ovarian granulosa cells, stimulating their proliferation and estrogen synthesis, while the LH component activates LH receptors on theca cells, promoting androgen production that serves as substrate for estrogen formation. The combined action drives the growth and maturation of ovarian follicles, preparing them for ovulation.

Side Effects

Menopur may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Injection site reactions: pain, redness, or swelling at the injection site.
  • Mild ovarian hyperstimulation syndrome: abdominal discomfort, bloating, and mild weight gain.
  • Headache: transient mild to moderate headache.
  • Nausea: occasional episodes of nausea.

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome: rapid weight gain, shortness of breath, fluid accumulation, and risk of thrombosis.
  • Ovarian torsion: sudden severe pelvic pain requiring surgical intervention.
  • Allergic reaction: rash, urticaria, or anaphylaxis.

Precautions & Warnings

Before using Menopur, clinicians should consider several precautionary measures to ensure patient safety.

  • Patient selection: assess ovarian reserve and risk factors for ovarian hyperstimulation.
  • Monitoring: perform serial ultrasound and estradiol measurements during stimulation cycles.
  • Contraindications: avoid use in confirmed pregnancy, active hormone‑sensitive tumors, or uncontrolled thyroid disease.
  • Drug interactions: review concomitant estrogen‑containing therapies that may interfere with intended ovarian response.
  • Pregnancy: discontinue Menopur if pregnancy is confirmed and provide appropriate counseling.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other medications that affect hormonal balance or ovarian response.

Major Interactions (Avoid)

  • Human chorionic gonadotropin (hCG): may exacerbate ovarian hyperstimulation when combined.
  • Estrogen therapy: can diminish the intended stimulatory effect of Menopur.
  • GnRH agonists used for down‑regulation: timing must be coordinated to prevent antagonistic effects.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may suppress endogenous gonadotropins and require careful scheduling.
  • Thyroid hormone replacement: stimulation may alter thyroid hormone requirements, necessitating monitoring.

Frequently Asked Questions

Menopur is a gonadotropin preparation used in reproductive medicine to stimulate ovarian follicular development. It is indicated for treating infertility caused by anovulation and for controlled ovarian stimulation in assisted reproductive technology procedures such as in‑vitro fertilisation.

Menotrophin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. After subcutaneous injection, the FSH component binds to receptors on granulosa cells, promoting estrogen production and follicle growth, while the LH component activates theca‑cell receptors, supporting androgen synthesis that is converted to estrogen, together driving follicular maturation.

The dose of Menopur is individualized. A qualified prescriber determines the amount, frequency, and duration of treatment based on the patient’s ovarian reserve, response to prior therapy, and the specific assisted‑reproductive protocol being used.

Menopur is not intended for use during an established pregnancy and should be discontinued if pregnancy occurs. Safety data for breastfeeding are limited; therefore, the product is generally avoided while nursing unless the prescriber judges that the benefit outweighs potential risk.

To order Menopur, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if required) and the necessary import documentation.

The primary alternative to Menopur is recombinant FSH (e.g., follitropin alfa). Menopur provides both FSH and LH activity in a single preparation, which can simplify dosing for patients who need LH support, whereas recombinant products typically contain only FSH and may require an additional LH‑containing drug for certain protocols.

Menopur should be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. Once reconstituted, use the solution according to the label instructions and discard any unused portion after the recommended period.

Menopur is supplied as a powder for solution for injection. After reconstitution with the appropriate diluent, it is administered by subcutaneous injection, typically into the abdominal wall or thigh, following the dosing schedule prescribed by the treating fertility specialist.

The most serious risks include severe ovarian hyperstimulation syndrome, which can cause rapid weight gain, fluid accumulation, shortness of breath, and thromboembolic events, and ovarian torsion, a surgical emergency presenting as sudden intense pelvic pain. Prompt medical evaluation is essential if these symptoms arise.

Menopur should not be used in women who are already pregnant, have active hormone‑sensitive cancers, uncontrolled thyroid disease, severe ovarian cysts, or a history of severe ovarian hyperstimulation syndrome. It is also contraindicated in patients with known hypersensitivity to any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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