Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotropin, the active ingredient in Menopur, is a Gonadotropin (FSH/LH) presented as a powder for solution for injection for subcutaneous use. It treats infertility related to anovulation, hypogonadotropic hypogonadism, and supports ovarian stimulation in assisted reproductive technology.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, fertility clinics and pharmacies worldwide.

Manufacturer / TM Owner

Ferring S.A.S.

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Indications & Clinical Uses

Menopur is a gonadotropin preparation used in fertility‑related treatment pathways.

  • Controlled ovarian hyperstimulation (COH): Facilitates development of multiple follicles for retrieval in assisted reproductive technology.
  • Anovulation or hypogonadotropic hypogonadism: Induces follicular growth and ovulation in women with deficient endogenous gonadotropins.
  • In vitro fertilization (IVF) cycles: Supports ovarian response to maximize oocyte yield during IVF protocols.

How It Works

  • Menotropin provides exogenous follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity, binding to their respective ovarian receptors. This stimulates granulosa cell proliferation, estradiol production, and the maturation of ovarian follicles, ultimately leading to ovulation when used within assisted reproductive protocols.

Side Effects

Menopur may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Abdominal discomfort or bloating
  • Injection site pain or erythema
  • Mild ovarian hyperstimulation symptoms such as mild abdominal pain
  • Headache
  • Nausea
  • Mild vaginal spotting

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (OHSS)
  • Multiple pregnancy
  • Severe allergic reaction (anaphylaxis)
  • Thromboembolic events
  • Severe abdominal pain or pelvic infection

Precautions & Warnings

Before initiating Menopur therapy, clinicians should consider several safety measures.

  • Monitor ovarian response: Perform regular ultrasound and estradiol assessments.
  • Avoid use in pregnancy: Not indicated for pregnant women.
  • Assess for hypersensitivity: Discontinue if allergic reaction occurs.
  • Use caution in patients with ovarian cysts or endocrine disorders.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other hormonal agents and medications that affect ovarian response.

Major Interactions (Avoid)

  • GnRH agonists: May increase risk of ovarian hyperstimulation syndrome.
  • hCG preparations: Can exacerbate ovarian response and increase OHSS risk.
  • Other gonadotropins: Overlapping activity may lead to excessive stimulation.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: May affect baseline hormone levels; monitor before starting.
  • Thyroid hormone therapy: Adjust dosing if thyroid function changes.
  • Corticosteroids: May alter ovarian response; observe patient closely.

Frequently Asked Questions

Menopur is used in assisted reproductive technology to stimulate the ovaries, enabling the development of multiple follicles for egg retrieval. It is indicated for controlled ovarian hyperstimulation, treatment of infertility caused by anovulation or hypogonadotropic hypogonadism, and to support ovulation induction in in‑vitro fertilisation cycles.

Menotropin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH). These hormones bind to specific receptors on ovarian cells, promoting granulosa cell proliferation, estradiol synthesis, and the maturation of ovarian follicles, ultimately leading to ovulation when used in fertility protocols.

The dose of Menopur is individualized and set by the prescribing clinician based on the patient’s ovarian reserve, response to prior stimulation, and the specific assisted reproduction protocol. Patients should follow the exact dosing instructions provided by their fertility specialist.

Menopur is not intended for use during pregnancy, and its safety in pregnant women has not been established. Women should avoid becoming pregnant while receiving Menopur until the treatment cycle is completed. Limited data are available regarding excretion in breast milk, so breastfeeding is generally not recommended during treatment.

To order Menopur, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. After verification, the team provides pricing, availability, shipping details (including cold‑chain handling if needed) and assists with import documentation.

Menopur provides a combination of FSH and LH activity in a single preparation, whereas some alternatives such as recombinant FSH (e.g., follitropin alfa) contain only FSH. The combined activity can be advantageous for patients with LH deficiency, but individual response varies, and clinicians choose the product based on patient profile and protocol requirements.

Menopur should be stored at 2‑8 °C in a refrigerator, protected from light. The vial must not be frozen or shaken. Once reconstituted, it should be used within the time frame specified in the product labeling and kept at controlled room temperature if required for a short period.

Menopur is supplied as a powder for solution for injection. After reconstitution with the appropriate diluent, it is administered subcutaneously, typically in the abdominal wall or thigh, according to the dosing schedule prescribed by the fertility specialist.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can be mild to severe, and the possibility of multiple pregnancy. Rare but severe reactions such as anaphylaxis, thromboembolic events, or severe abdominal pain should prompt immediate medical evaluation.

Menopur should not be used in women who are already pregnant, have known hypersensitivity to menotropin or any excipients, or have uncontrolled endocrine disorders that could be aggravated by gonadotropin therapy. Caution is also advised for patients with ovarian cysts, severe ovarian disease, or a history of thromboembolic events.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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