Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotropin, the active ingredient in Menopur, is a gonadotropin presented as an injectable solution for subcutaneous use. It treats infertility related to anovulation and is used in assisted reproductive protocols such as IVF.
GNH India supplies Menopur as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, fertility clinics and pharmacies worldwide.

Manufacturer / TM Owner

Ferring Hellas Mepe

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Indications & Clinical Uses

Menopur, a gonadotropin used in reproductive medicine, is indicated for the following clinical situations:

  • Infertility due to anovulation: stimulates follicular development to enable ovulation in women who do not ovulate spontaneously.
  • Controlled ovarian stimulation for in‑vitro fertilization (IVF): supports multiple follicle growth to increase oocyte retrieval for IVF cycles.
  • Assisted reproductive technology (ART) protocols: provides FSH and LH activity required in various ART treatment regimens.

How It Works

  • Menotropin is a purified preparation of human follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) derived from the urine of post‑menopausal women. After subcutaneous injection it binds to FSH and LH receptors on ovarian granulosa and theca cells, activating intracellular signaling that promotes follicular recruitment, growth, and final maturation, thereby facilitating ovulation in assisted reproductive cycles.

Side Effects

Menopur may cause a range of adverse reactions, which are generally related to its hormonal activity and the injection process.

Common Side Effects

  • Injection site reactions: pain, redness, or swelling at the injection site.
  • Abdominal discomfort: mild bloating or cramping.
  • Headache: transient headache episodes.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (OHSS): severe fluid accumulation, rapid weight gain, and respiratory distress.
  • Multiple pregnancy: increased risk of twins or higher‑order gestations.
  • Allergic reactions: rash, urticaria, or anaphylaxis.

Precautions & Warnings

When using Menopur, clinicians should observe several safety considerations:

  • Dose individualization: dosing is individualized based on ovarian response monitoring.
  • Monitoring for OHSS: patients should be observed for signs of ovarian hyperstimulation syndrome.
  • Contraindications: not for use in women with uncontrolled thyroid disease, ovarian cysts, or hormone‑dependent tumors.
  • Pregnancy considerations: avoid use during established pregnancy.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other medications; awareness of major and moderate interactions helps ensure safe use.

Major Interactions (Avoid)

  • GnRH antagonists: may reduce efficacy of Menotropin.
  • Aromatase inhibitors: concurrent use can alter estrogen feedback.
  • High‑dose estrogen therapy: may blunt ovarian response.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: increased risk of bleeding with ovarian cyst rupture.
  • Corticosteroids: may affect hormone metabolism.
  • Thyroid hormone replacement: monitor thyroid function during treatment.

Frequently Asked Questions

Menopur is prescribed to treat infertility caused by anovulation, to provide controlled ovarian stimulation in in‑vitro fertilization (IVF) cycles, and to support various assisted reproductive technology (ART) protocols that require both FSH and LH activity.

Menotropin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH). After subcutaneous injection it binds to FSH and LH receptors on ovarian cells, triggering signaling pathways that promote follicle recruitment, growth, and maturation, ultimately leading to ovulation.

The dose of Menopur is individualized for each patient. The prescribing clinician determines the amount and schedule based on ovarian response monitoring, treatment goals, and patient characteristics.

Menopur is not intended for use during an established pregnancy and its safety in breastfeeding has not been established. It should be discontinued once pregnancy is confirmed, and women should discuss breastfeeding considerations with their healthcare provider.

To order Menopur, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Menopur provides both FSH and LH activity in a single preparation, whereas Follitropin alfa supplies only FSH. The combined activity of Menopur can simplify dosing in protocols that require both hormones, while Follitropin alfa may be combined with a separate LH product if needed.

Menopur must be stored at 2‑8 °C (refrigerated), protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any solution that appears discolored or contains particles.

Menopur is administered as a subcutaneous injection, typically into the abdomen or thigh. The solution may require reconstitution according to the product label, and the injection should be performed using aseptic technique by a trained healthcare professional.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can cause severe fluid shifts and respiratory distress; multiple pregnancy, which raises obstetric complications; and allergic reactions ranging from rash to anaphylaxis. Prompt medical attention is required if any of these occur.

Menopur should not be used by women with uncontrolled thyroid disease, ovarian cysts, hormone‑dependent tumors, or those who are already pregnant. It is also contraindicated in individuals with known hypersensitivity to menotropin or any excipients in the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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