Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotropin, the active ingredient in Menopur, is a gonadotropin (biologic) presented as an injectable solution for subcutaneous use. It provides both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity to support ovarian follicular development and ovulation in women with infertility.
GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ferring Magyarország Gyógyszerkereskedelmi Kft.

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Indications & Clinical Uses

Menopur is used in reproductive medicine to address disorders of ovarian function and to support assisted reproductive technologies.

  • Infertility due to anovulation: stimulates follicular growth and induces ovulation in women who do not ovulate spontaneously.
  • Controlled ovarian stimulation for IVF: enhances the number of mature oocytes retrieved during in‑vitro fertilisation cycles.
  • Hypogonadotropic hypogonadism: provides exogenous FSH and LH activity to trigger ovulation in women with deficient gonadotropin secretion.

How It Works

  • Menotropin contains a mixture of FSH and LH isoforms that bind to their respective receptors on ovarian granulosa and theca cells. Activation of these receptors stimulates intracellular cAMP pathways, promoting follicular maturation, estradiol synthesis, and the LH surge required for final oocyte maturation and ovulation.

Side Effects

Menopur may cause a range of adverse reactions, most of which are related to ovarian stimulation and injection site responses.

Common Side Effects

  • Injection site pain or erythema: mild discomfort at the subcutaneous injection site.
  • Ovarian hyperstimulation syndrome (mild): abdominal bloating, mild weight gain.
  • Nausea or vomiting: transient gastrointestinal upset.
  • Headache: mild to moderate intensity.
  • Mood changes: irritability or emotional lability.

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome: rapid weight gain, ascites, respiratory distress.
  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Ovarian torsion: acute pelvic pain requiring surgical intervention.
  • Allergic reaction: rash, urticaria, or anaphylaxis.
  • Ectopic pregnancy: implantation outside the uterine cavity.

Precautions & Warnings

Before initiating Menopur therapy, clinicians should assess patient suitability and monitor response closely.

  • Baseline ovarian assessment: perform ultrasound to evaluate follicle count and size.
  • Monitor estradiol levels: regular blood tests to detect excessive stimulation.
  • Adjust dose as needed: titrate based on follicular response and estradiol trends.
  • Contraindications: avoid in patients with ovarian cysts, uncontrolled thyroid disease, or active malignancy.
  • Patient counseling: inform about symptoms of ovarian hyperstimulation syndrome and when to seek medical attention.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur may interact with other medications that affect ovarian response or hormone metabolism.

Major Interactions (Avoid)

  • GnRH antagonists used concurrently without proper protocol: may blunt intended ovarian stimulation.
  • High‑dose estrogen therapy: can suppress endogenous gonadotropin release.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin): increased risk of thromboembolic complications in ovarian hyperstimulation.
  • Thyroid hormone replacement: altered dosing may be needed due to changes in hormone binding.
  • Corticosteroids: may affect ovarian response and fluid balance.

Frequently Asked Questions

Menopur is a biologic fertility agent that provides FSH and LH activity to stimulate ovarian follicular development. It is indicated for infertility due to anovulation, controlled ovarian stimulation in assisted reproductive technologies such as IVF, and induction of ovulation in women with hypogonadotropic hypogonadism.

Menotropin contains a mixture of follicle‑stimulating hormone and luteinizing hormone isoforms. These hormones bind to their specific receptors on ovarian cells, activating intracellular signaling pathways that promote follicle growth, estradiol production, and the LH surge needed for final oocyte maturation and ovulation.

The dose of Menopur is individualized. A prescribing clinician determines the amount and frequency based on the patient’s ovarian reserve, response to prior stimulation, and the specific assisted reproductive protocol being used.

Menopur is intended for use before conception to achieve pregnancy. Its safety in established pregnancy or while breastfeeding has not been established, and it should not be used during those periods unless specifically directed by a qualified specialist.

To place an order, submit an enquiry on the Menopur product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any required import documentation.

Menopur provides both FSH and LH activity in a single preparation, whereas some alternatives offer only FSH (e.g., recombinant FSH) and require separate LH supplementation. This combined profile can simplify dosing schedules but may have a different safety and response profile that clinicians consider when selecting therapy.

Menopur must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside this range.

Menopur is supplied as an injectable solution for subcutaneous injection. The medication is typically drawn into a sterile syringe and administered into the subcutaneous tissue of the abdomen or thigh, following the dosing schedule prescribed by the treating physician.

The most serious risks include severe ovarian hyperstimulation syndrome, which can cause rapid weight gain, fluid accumulation, and respiratory compromise, as well as ovarian torsion, thromboembolic events, and rare allergic reactions such as anaphylaxis. Prompt medical attention is required if these symptoms occur.

Menopur is contraindicated in women with active ovarian cysts, uncontrolled thyroid disease, known hypersensitivity to menotropin, or those who are pregnant or breastfeeding. It should also be used with caution in patients with a history of thromboembolic disease or severe cardiovascular conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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