Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotropin, the active ingredient in Menopur, is a gonadotropin (FSH/LH) preparation presented as a powder for solution for injection for subcutaneous use. It treats infertility caused by anovulation and supports assisted reproductive technology procedures in women.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, fertility clinics and pharmacies worldwide with strict quality, regulatory compliance and reliable cold‑chain logistics.

Manufacturer / TM Owner

Ferring Lægemidler A/S

1
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Indications & Clinical Uses

  • Menopur is used in reproductive medicine to stimulate ovarian follicular development in specific infertility contexts.
  • Anovulatory infertility: promotes follicular growth to enable ovulation.
  • IVF cycles: enhances ovarian response to stimulation, increasing the number of retrieved oocytes.
  • Ovarian stimulation for egg retrieval: improves the yield of mature oocytes for assisted reproduction.
  • Donor egg programs: facilitates controlled ovarian hyperstimulation to obtain donor oocytes.
  • Endometriosis‑related infertility: may be incorporated into stimulation protocols to improve oocyte yield.

How It Works

  • Menotropin provides exogenous follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. After subcutaneous injection, it binds to FSH and LH receptors on ovarian granulosa and theca cells, stimulating follicular growth, estradiol production, and final oocyte maturation, thereby supporting ovulation and assisted reproductive procedures.

Side Effects

Menopur may cause a range of adverse reactions, which are generally related to its hormonal activity and injection route.

Common Side Effects

  • Injection site pain or erythema
  • Mild ovarian hyperstimulation syndrome (abdominal discomfort, bloating)
  • Nausea or vomiting
  • Headache
  • Fatigue

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome (rapid weight gain, shortness of breath)
  • Thromboembolic events (deep vein thrombosis, pulmonary embolism)
  • Anaphylactic or severe allergic reactions
  • Ovarian torsion

Precautions & Warnings

  • When using Menopur, clinicians should observe several precautionary measures to minimize risks and ensure optimal outcomes.
  • Baseline ovarian assessment: evaluate follicular reserve before initiating therapy.
  • Monitor for ovarian hyperstimulation syndrome: watch for abdominal distension, rapid weight gain, or shortness of breath.
  • Avoid use in uncontrolled thyroid disease: correct thyroid function prior to treatment.
  • Use cautiously in hormone‑sensitive tumors: assess risk‑benefit ratio.
  • Pregnancy testing: confirm negative pregnancy before starting.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other medications that affect hormonal balance or coagulation, requiring careful management.

Major Interactions (Avoid)

  • GnRH agonists: concurrent use may increase risk of severe ovarian hyperstimulation.
  • Estrogen‑containing contraceptives: antagonize Menopur’s stimulatory effect on the ovary.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: monitor for thromboembolic events if ovarian hyperstimulation occurs.
  • Corticosteroids: may alter ovarian response, adjust monitoring.
  • Insulin sensitizers (e.g., metformin): observe glucose control during stimulation.

Frequently Asked Questions

Menopur is prescribed to treat infertility caused by anovulation and to support assisted reproductive technology procedures such as in‑vitro fertilisation (IVF). It helps stimulate the development of ovarian follicles, increasing the chance of ovulation and the retrieval of mature oocytes for fertilisation.

Menotropin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH). After subcutaneous injection, it binds to FSH and LH receptors on ovarian cells, promoting follicular growth, estradiol synthesis, and final oocyte maturation, thereby facilitating ovulation and improving outcomes in assisted reproduction cycles.

The dose of Menopur is individualized and set by the prescribing clinician based on the patient’s ovarian reserve, treatment protocol and response to stimulation. Dosing may be adjusted during a cycle according to ultrasound and hormonal monitoring, and no fixed regimen is provided here.

Menopur is not indicated for use during an established pregnancy, and its safety in breastfeeding has not been established. It is generally avoided in pregnant or lactating women, and pregnancy testing is required before initiating therapy.

To order Menopur, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

The primary alternatives to Menopur are recombinant FSH products such as follitropin alfa (Gonal‑F) or beta (Follitropin beta). Menopur provides both FSH and LH activity in a single preparation, which can reduce the need for separate LH supplementation, whereas recombinant products contain only FSH and may require an additional LH source for some protocols.

Menopur should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. The powder should be reconstituted with the supplied diluent immediately before use, and any unused solution should be discarded according to local regulations.

Menopur is supplied as a sterile powder for solution for injection. After reconstitution with the appropriate diluent, it is administered by subcutaneous injection, typically in the abdominal wall or thigh, according to the dosing schedule determined by the treating specialist.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can cause rapid weight gain, abdominal pain, and respiratory distress; thromboembolic events such as deep‑vein thrombosis; and rare but potentially life‑threatening allergic reactions, including anaphylaxis.

Menopur should be avoided in women with confirmed pregnancy, uncontrolled thyroid disease, active hormone‑sensitive cancers, severe ovarian cysts, or those who have experienced severe OHSS in a previous cycle. Contra‑indications also include known hypersensitivity to menotropin or any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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