Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotrophin, the active ingredient in Menopur, is a gonadotropin (FSH/LH) preparation presented as an injectable solution for subcutaneous use. It stimulates ovarian follicular development and is used in women with infertility.
GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ferring Ireland Ltd.

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Indications & Clinical Uses

Menopur acts on the reproductive hormone pathway to support follicular growth and ovulation in women with infertility.

  • Induction of ovulation in anovulatory women: promotes follicular growth to achieve ovulation.
  • Controlled ovarian stimulation for assisted reproductive technologies (IVF, IUI): enhances multiple follicle development for egg retrieval.
  • Treatment of infertility associated with hypogonadotropic hypogonadism: provides exogenous FSH and LH activity to restore normal ovarian function.

How It Works

  • Menotrophin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. FSH binds to receptors on granulosa cells, stimulating aromatase and estrogen production, while LH binds to theca cells, promoting androgen synthesis. The combined action supports follicular maturation, ovulation, and luteal phase support in the ovary.

Side Effects

Menopur may cause a range of adverse reactions, most of which are related to its hormonal activity and injection route.

Common Side Effects

  • Injection site reactions: redness, swelling, or pain at the injection site.
  • Mild ovarian hyperstimulation syndrome: abdominal discomfort, bloating, or mild weight gain.
  • Headache: occasional mild to moderate intensity.
  • Nausea: occasional feeling of queasiness.

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome: rapid weight gain, shortness of breath, electrolyte imbalance, and possible hospitalization.
  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Allergic reactions: rash, urticaria, or anaphylaxis.

Precautions & Warnings

Before initiating Menopur, clinicians should consider several safety measures.

  • Patient selection: assess ovarian reserve and individual risk factors for hyperstimulation.
  • Monitoring: perform regular ultrasound and estradiol measurements to detect overstimulation early.
  • Concomitant medications: avoid combining with other gonadotropins unless specifically directed.
  • Pregnancy considerations: discontinue Menopur once pregnancy is confirmed.
  • Contraindications: not for use in patients with ovarian cysts, estrogen‑dependent tumors, or uncontrolled thyroid disease.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • GnRH agonists or antagonists: concurrent use may alter ovarian response; coordinate timing under specialist supervision.
  • Thyroid hormone therapy: uncontrolled thyroid disease can affect treatment efficacy; achieve euthyroid status before starting.
  • High‑dose corticosteroids: may increase risk of ovarian hyperstimulation; monitor closely.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may suppress endogenous gonadotropins; ensure appropriate washout period before Menopur.
  • Anticoagulants: risk of thrombosis may be heightened with ovarian hyperstimulation; monitor coagulation parameters.
  • Diuretics: may mask fluid retention signs of hyperstimulation; observe patient closely.

Frequently Asked Questions

Menopur is a gonadotropin preparation used to induce ovulation in anovulatory women, to stimulate the ovaries during assisted reproductive technologies such as in‑vitro fertilisation (IVF) or intra‑uterine insemination (IUI), and to treat infertility caused by hypogonadotropic hypogonadism by providing both FSH and LH activity.

Menotrophin contains both follicle‑stimulating hormone (FSH) and luteinising hormone (LH). FSH stimulates granulosa cells to promote follicle growth and estrogen production, while LH acts on theca cells to produce androgens that are converted to estrogen. The combined hormonal activity supports follicular maturation and ovulation.

The dose of Menopur is individualized. A qualified prescriber determines the amount and frequency based on the patient’s ovarian response, underlying condition, and treatment protocol. No fixed regimen is provided in public information; dosing is adjusted during therapy under medical supervision.

Menopur is not intended for use during an established pregnancy and should be discontinued once pregnancy is confirmed. Safety data for breastfeeding are limited, and the drug is generally not recommended for nursing mothers unless the benefit outweighs potential risk, as decided by the treating physician.

To order Menopur, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The team then provides pricing, availability, shipping details (including cold‑chain logistics if needed) and assists with import documentation.

Menopur provides both FSH and LH activity in a single preparation, whereas many recombinant products contain only FSH. This dual activity can be advantageous for patients who require LH supplementation, such as those with hypogonadotropic hypogonadism. However, recombinant FSH may offer more precise dosing and lower risk of immunogenicity. Choice depends on clinical indication, patient response and physician preference.

Menopur must be stored at 2‑8 °C (refrigerated). Keep the vials in the original packaging, protect them from light, and do not freeze or shake the solution. If the product reaches room temperature for a short period during administration, it may be used, but it should be returned to refrigeration promptly.

Menopur is supplied as a sterile injectable solution for subcutaneous injection. The vial is typically reconstituted with the diluent provided, mixed gently, and administered into the subcutaneous tissue of the abdomen or thigh using a sterile needle. Injection technique and site rotation are important to minimise local reactions.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can cause rapid weight gain, abdominal pain, shortness of breath and electrolyte disturbances, and thromboembolic events such as deep‑vein thrombosis. Rarely, anaphylactic reactions may occur. Patients should be monitored closely for these complications, especially during the first treatment cycles.

Menopur is contraindicated in women with ovarian cysts, estrogen‑dependent neoplasms, uncontrolled thyroid disease, severe liver dysfunction, or those who are pregnant. It should also be avoided in patients with known hypersensitivity to menotrophin or any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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