Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotrophin, the active ingredient in Menopur, is a gonadotropin presented as a lyophilized powder for injection for subcutaneous use. It provides follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity to stimulate ovarian follicular development and ovulation, addressing infertility due to anovulation and supporting controlled ovarian hyperstimulation in assisted reproductive technology cycles.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory conformity for fertility treatment programs and patient‑centric care.

Manufacturer / TM Owner

Ferring Legemidler As

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Indications & Clinical Uses

Menopur, a gonadotropin used in reproductive endocrinology, is indicated for the following clinical situations:

  • Infertility due to anovulation: induces follicular development to achieve ovulation.
  • Controlled ovarian hyperstimulation for assisted reproductive technology (ART): supports multiple follicle growth for IVF/ICSI cycles.
  • Ovarian stimulation for intrauterine insemination (IUI): enhances follicular response to improve pregnancy rates.

How It Works

  • Menotrophin contains equal amounts of follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. The FSH component binds to FSH receptors on granulosa cells, promoting estradiol synthesis and follicular maturation, while the LH component activates LH receptors on theca and luteal cells, supporting androgen production and triggering ovulation when a sufficient follicular size is reached.

Side Effects

Menopur may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Injection site pain or erythema.
  • Mild abdominal discomfort or bloating.
  • Nausea or mild vomiting.
  • Breast tenderness or swelling.

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome (OHSS).
  • Ovarian torsion.
  • Thromboembolic events.
  • Allergic reaction or anaphylaxis.
  • Multiple pregnancy.
  • Visual disturbances or sudden headache.

Precautions & Warnings

When using Menopur, clinicians should observe several safety measures.

  • Monitor ovarian response: perform serial ultrasound and estradiol assessments.
  • Assess OHSS risk: consider patient age, BMI, and prior response.
  • Adjust dose based on individual response and follicular development.
  • Contraindicated in pregnancy: avoid use once conception is confirmed.
  • Avoid in patients with uncontrolled thyroid disease or severe ovarian pathology.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur may interact with other agents that influence ovarian response or coagulation.

Major Interactions (Avoid)

  • Concurrent use of other gonadotropins may amplify OHSS risk.
  • Simultaneous hCG administration for ovulation trigger can increase severe OHSS.
  • Estrogen‑containing contraceptives may reduce efficacy of stimulation.
  • Anticoagulants may heighten bleeding risk during oocyte retrieval.

Moderate Interactions (Monitor Closely)

  • NSAIDs can mask pain symptoms of OHSS; monitor closely.
  • Corticosteroids may alter follicular dynamics; adjust monitoring.
  • Thyroid hormone therapy may require dose adjustment of Menopur.
  • Anti‑emetic agents may affect patient comfort but not efficacy.

Frequently Asked Questions

Menopur is a gonadotropin preparation used to stimulate ovarian follicular development in women with infertility due to anovulation and to support controlled ovarian hyperstimulation for assisted reproductive technology procedures such as in‑vitro fertilisation.

Menotrophin provides both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. The FSH component promotes growth and maturation of ovarian follicles, while the LH component supports androgen conversion and triggers ovulation once follicles reach the appropriate size.

The dose of Menopur is individualized. A prescribing clinician determines the amount and schedule based on the patient’s ovarian reserve, response to prior stimulation, and the specific assisted‑reproduction protocol being used.

Menopur is contraindicated once pregnancy is confirmed and should not be used during pregnancy. Safety during breastfeeding has not been established, so it is generally avoided in lactating women unless the benefit outweighs potential risk.

Submit an enquiry on the Menopur product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Menopur contains a fixed 1:1 ratio of FSH to LH activity, whereas some alternatives provide only FSH (e.g., follitropin alfa) or separate LH preparations. The combined activity can be advantageous for patients who benefit from simultaneous LH support, but the choice depends on individual response and clinician preference.

Menopur should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. After reconstitution, the solution should be used promptly according to the product label and discarded if not used within the recommended time.

Menopur is supplied as a lyophilized powder for injection. After reconstitution with the appropriate diluent, it is administered subcutaneously, usually once daily, following the dosing schedule prescribed by the fertility specialist.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can lead to fluid shifts, thromboembolic events, ovarian torsion, and the possibility of multiple pregnancy. Prompt monitoring and dose adjustment are essential to mitigate these risks.

Menopur should not be used in women who are already pregnant, have uncontrolled thyroid disease, severe ovarian pathology, or a history of severe OHSS. It is also contraindicated in patients with known hypersensitivity to any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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