Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotropin, the active ingredient in Menopur, is a gonadotropin presented as an injection solution for subcutaneous use. It treats infertility related to anovulation and is employed in assisted reproductive technology to stimulate ovarian follicular development and estrogen production, supporting egg retrieval for in‑vitro fertilisation cycles.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance, regulatory compliance, and reliable cold‑chain logistics for biologic products. The company adheres to stringent Good Distribution Practice standards and provides comprehensive documentation for regulatory submissions.

Manufacturer / TM Owner

Ferring S.A.U.

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Indications & Clinical Uses

Menopur (menotropin) acts on the hypothalamic‑pituitary‑ovarian axis to promote follicular growth and ovulation in women undergoing fertility treatment.

  • Infertility due to anovulation: stimulates follicular development to enable ovulation.
  • Assisted reproductive technology (ART): provides combined FSH and LH activity for controlled ovarian stimulation.
  • Controlled ovarian stimulation: enhances estrogen production and follicle maturation for egg retrieval.

How It Works

  • Menotropin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) isoforms. It binds to FSH receptors on granulosa cells and LH receptors on theca cells, activating intracellular signaling pathways that promote follicular growth, estradiol synthesis, and final oocyte maturation leading to ovulation.

Side Effects

Menopur may cause a range of adverse reactions, most of which are related to its hormonal activity and injection route.

Common Side Effects

  • Injection site pain or erythema
  • Abdominal discomfort or bloating
  • Nausea or mild vomiting
  • Headache
  • Mild ovarian hyperstimulation
  • Fatigue

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome (OHSS)
  • Multiple pregnancy
  • Allergic reaction or anaphylaxis
  • Thromboembolic events
  • Ectopic pregnancy
  • Severe abdominal pain

Precautions & Warnings

When using Menopur, careful monitoring and patient selection are essential to minimise risks.

  • Dose individualisation: adjust based on ovarian response and monitoring results.
  • Monitor for ovarian hyperstimulation: watch for rapid weight gain, abdominal distension, or shortness of breath.
  • Assess thyroid function: avoid use in uncontrolled thyroid disease.
  • Confirm negative pregnancy test before initiation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other hormonal or systemic agents that affect ovarian response.

Major Interactions (Avoid)

  • GnRH antagonists: may reduce Menopur efficacy.
  • Oral contraceptives: suppress endogenous gonadotropins, interfering with stimulation.
  • High‑dose estrogen therapy: may alter ovarian response.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone replacement: monitor thyroid status during treatment.
  • Glucocorticoids: may affect follicular development.
  • Anticoagulants: monitor bleeding risk if invasive procedures are performed.

Frequently Asked Questions

Menopur (Menotropin) is a gonadotropin injection used in fertility treatment to stimulate ovarian follicular development in women with anovulation, to support controlled ovarian stimulation in assisted reproductive technology, and to facilitate egg retrieval for in‑vitro fertilisation cycles.

Menotropin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) isoforms. It binds to FSH receptors on granulosa cells and LH receptors on theca cells, promoting follicle growth, estrogen synthesis, and final maturation that leads to ovulation.

The dose of Menopur is individualized by the prescribing clinician based on the patient’s ovarian response, age, body weight, and treatment protocol. The prescriber determines the number of international units (IU) per injection and the overall treatment schedule.

Menopur is intended for use before conception to induce ovulation; it is not administered during an established pregnancy. Safety data for use in pregnancy or while breastfeeding are limited, and the product should be avoided in these situations unless specifically directed by a qualified healthcare professional.

To place an order, submit an enquiry on the Menopur product page at gnhindia.com, providing the required quantity and institutional credentials. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional verification before supplying pricing, availability, cold‑chain shipping details and necessary import documentation.

Menopur provides both FSH and LH activity in a single preparation, whereas some alternatives such as recombinant FSH contain only FSH and require separate LH supplementation. This combined profile can simplify dosing regimens, but individual response, cost considerations and specific protocol requirements may influence the choice of therapy.

Menopur must be stored refrigerated at 2‑8 °C (36‑46 °F). Keep the vial in its original carton, protect it from light, and do not freeze or shake the solution. Once reconstituted, use within the time frame specified in the product labeling and retain refrigeration.

Menopur is supplied as a sterile injection solution for subcutaneous use. The prescribed dose is drawn into a syringe and injected into the subcutaneous tissue of the abdomen or thigh, typically once daily, following the schedule defined by the fertility specialist.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can cause abdominal pain, rapid weight gain, and fluid accumulation, and the possibility of multiple pregnancy. Severe allergic reactions and rare thromboembolic events are also critical concerns that require immediate medical attention.

Menopur is contraindicated in women with known hypersensitivity to menotropin or any component of the formulation, uncontrolled thyroid disease, active ovarian cysts, or severe ovarian failure. It should also be avoided in patients with a history of severe OHSS or those who are currently pregnant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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