Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotropin, the active ingredient in Menopur, is a gonadotropin presented as a powder for solution for injection for subcutaneous use. It stimulates follicular development and ovulation in women undergoing assisted reproductive technology, anovulatory patients, and those with hypogonadotropic hypogonadism.

GNH India supplies Menopur as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ferring Lægemidler A/S

1
Pack/s
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Indications & Clinical Uses

Menotropin (Menopur) is used in the reproductive endocrine pathway to support follicular growth and ovulation.

  • Ovarian stimulation for assisted reproductive technology (ART): enhances follicle development to increase the number of retrievable oocytes.
  • Induction of ovulation in anovulatory women: promotes ovulation in patients with conditions such as polycystic ovary syndrome.
  • Treatment of hypogonadotropic hypogonadism: provides necessary FSH and LH activity to stimulate gonadal function in patients with deficient gonadotropin secretion.

How It Works

  • Menotropin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. The FSH component binds to FSH receptors on ovarian granulosa cells, stimulating aromatase activity and estradiol production, while the LH component activates LH receptors on theca cells, supporting androgen synthesis and luteinization. Together they promote follicular maturation and trigger ovulation.

Side Effects

Menotropin may be associated with a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Ovarian hyperstimulation syndrome (mild): abdominal bloating, nausea, mild weight gain.
  • Headache: transient headache.
  • Nausea: occasional nausea.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (severe): rapid weight gain, ascites, thromboembolism.
  • Multiple pregnancy: increased risk of twins or higher‑order gestations.
  • Allergic reaction: rash, urticaria, anaphylaxis.

Precautions & Warnings

When using Menotropin, clinicians should observe specific safety measures.

  • Patient selection: assess ovarian reserve and risk factors for OHSS before initiating therapy.
  • Monitoring: perform regular ultrasound and estradiol measurements to adjust dose.
  • Contraindications: avoid in active ovarian cysts, uncontrolled thyroid disease, or estrogen‑dependent tumors.
  • Pregnancy: discontinue once pregnancy is confirmed.
  • Thromboembolic risk: monitor for signs of blood clots in high‑risk patients.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menotropin can interact with other agents that affect hormonal balance or clotting.

Major Interactions (Avoid)

  • GnRH agonists/antagonists: may alter response and increase OHSS risk.
  • Hormonal contraceptives: can suppress endogenous gonadotropin response, reducing efficacy.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: increased risk of thrombosis with OHSS.
  • Thyroid hormone therapy: may require dose adjustments.
  • Steroids: may affect ovarian response.

Frequently Asked Questions

Menopur contains menotropin, a gonadotropin that provides both FSH and LH activity. It is used to stimulate ovarian follicle development for assisted reproductive technology, to induce ovulation in anovulatory women, and to treat hypogonadotropic hypogonadism by restoring normal gonadal function.

Menotropin’s FSH component binds to FSH receptors on granulosa cells, promoting estrogen production and follicle growth. The LH component activates LH receptors on theca cells, supporting androgen synthesis and luteinization. Together they mimic the natural hormonal signals that lead to mature follicle formation and ovulation.

The dose of Menopur is individualized. A prescribing clinician determines the amount and schedule based on the patient’s ovarian reserve, treatment protocol, and response to monitoring. Dosing is adjusted according to ultrasound and hormone level assessments during the treatment cycle.

Menopur is intended for use before pregnancy to achieve ovulation or oocyte retrieval. Once pregnancy is confirmed, treatment is stopped. Safety data for use during pregnancy or breastfeeding are limited, and the product is generally not recommended in these periods.

To request Menopur, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Menopur provides both FSH and LH activity in a single preparation, whereas some alternatives supply only FSH (e.g., recombinant FSH) and require separate LH supplementation. This combined profile can simplify dosing and may be advantageous in protocols that need both hormones for optimal follicular response.

Menopur should be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. Once reconstituted, use the solution according to the manufacturer’s instructions and discard any unused portion after the recommended time.

Menopur is supplied as a powder for solution for injection. After reconstitution with the appropriate diluent, it is administered subcutaneously, typically in the abdominal wall or thigh, according to the dosing schedule prescribed by the treating physician.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can cause rapid weight gain, fluid accumulation, and thromboembolic events, as well as the possibility of multiple pregnancies and rare allergic reactions such as anaphylaxis. Patients should be closely monitored for these complications.

Menopur is contraindicated in women with active ovarian cysts, uncontrolled thyroid disease, estrogen‑dependent tumors, or known hypersensitivity to menotropin. It should also be avoided in patients at high risk for severe OHSS or those with conditions that make pregnancy unsafe.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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