Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotropin, the active ingredient in Menopur, is a gonadotropin presented as a lyophilized powder for solution for injection for subcutaneous use. It treats female infertility due to anovulation, supports controlled ovarian stimulation for assisted reproductive technologies, and may be used in male infertility as part of combination therapy.

GNH India supplies Menopur as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ferring Pharmaceuticals Ltd.

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Indications & Clinical Uses

Menopur (menotropin) is used in reproductive hormone therapy to stimulate follicular development and ovulation.

  • Female infertility due to anovulation: induces follicular growth to enable ovulation.
  • Controlled ovarian stimulation for assisted reproductive technologies (e.g., IVF): supports multiple follicle development for egg retrieval.
  • Male infertility (as part of combination therapy): provides LH activity to stimulate testosterone production and spermatogenesis.

How It Works

  • Menotropin is a purified preparation containing human follicle‑stimulating hormone (FSH) and luteinizing hormone (LH). It binds to FSH receptors on ovarian granulosa cells to promote follicular recruitment and growth, while LH receptor activation on theca and Leydig cells triggers final maturation, ovulation, and testosterone production, thereby facilitating fertility in both females and males.

Side Effects

Menopur may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Injection site reactions: redness, swelling, or pain at the injection site.
  • Mild ovarian hyperstimulation syndrome: abdominal discomfort and bloating.
  • Headache: mild to moderate intensity.
  • Nausea: occasional feeling of queasiness.
  • Mood changes: irritability or emotional lability.

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome: rapid weight gain, shortness of breath, electrolyte imbalance.
  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Allergic reactions: rash, urticaria, anaphylaxis.

Precautions & Warnings

When using Menopur, clinicians should observe several safety measures.

  • Individualize dosing: adjust based on ovarian response monitored by ultrasound and hormone levels.
  • Monitor for ovarian hyperstimulation syndrome: watch for abdominal pain, rapid weight gain, or shortness of breath.
  • Avoid use in uncontrolled thyroid disease: correct thyroid function before initiating therapy.
  • Use caution in patients with estrogen‑dependent tumors: assess risk versus benefit.
  • Pregnancy testing: confirm non‑pregnant status before starting treatment.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other medications that affect hormonal balance or coagulation.

Major Interactions (Avoid)

  • GnRH agonists used for down‑regulation: may exacerbate ovarian hyperstimulation if not properly timed.
  • High‑dose estrogen therapy: can blunt response to menotropin.
  • Anticoagulants (e.g., warfarin): increased risk of ovarian hemorrhage.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone replacement: monitor thyroid function as menotropin can affect hormone levels.
  • Corticosteroids: may alter ovarian response, requiring monitoring.
  • Insulin or oral hypoglycemics: watch for changes in glucose control during ovarian stimulation.

Frequently Asked Questions

Menopur is prescribed to treat infertility by stimulating ovarian follicular development and ovulation in women with anovulation, supporting controlled ovarian stimulation for assisted reproductive technologies such as IVF, and, in combination with other agents, aiding male infertility through LH activity that promotes testosterone production.

Menotropin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH). FSH binds to receptors on ovarian granulosa cells to recruit and grow follicles, while LH activates receptors on theca and Leydig cells, triggering final maturation, ovulation, and testosterone synthesis, thereby facilitating gamete development in both sexes.

The dose of Menopur is individualized and determined by the prescribing clinician based on the patient’s response, treatment protocol, and monitoring results. Specific dosing regimens are not standardized and should be set by a qualified healthcare professional.

Menopur is not indicated for use during an established pregnancy and should only be administered after confirming a non‑pregnant status. Safety data for breastfeeding are limited, and the product is generally avoided in lactating women unless the benefits outweigh potential risks as assessed by a physician.

To order Menopur, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed) and the necessary import documentation.

Menopur is a urinary‑derived menotropin containing both FSH and LH activity, whereas many alternatives are recombinant forms that provide only FSH (e.g., follitropin alfa) or separate recombinant LH. Menopur offers combined activity in a single preparation, which can simplify dosing but may have slightly different immunogenicity and cost profiles compared with recombinant products.

Menopur should be stored at 2‑8 °C (refrigerated), protected from light, and must not be frozen or shaken. After reconstitution, the solution should be used promptly according to the product’s stability guidelines and any remaining material discarded if not used within the specified time frame.

Menopur is supplied as a lyophilized powder that must be reconstituted with the provided diluent. The resulting solution is administered by subcutaneous injection, typically in the abdominal wall or thigh, following the dosing schedule prescribed by the treating specialist.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can cause rapid weight gain, shortness of breath, and electrolyte disturbances, as well as thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, and rare but potentially life‑threatening allergic reactions like anaphylaxis.

Menopur is contraindicated in individuals with known hypersensitivity to menotropin or any component of the formulation, in patients with uncontrolled thyroid disease, in those with estrogen‑dependent neoplasms unless benefits outweigh risks, and in pregnant women. It should also be used with caution in patients with severe ovarian cysts or a history of thromboembolic disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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