Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotrophin, the active ingredient in Menopur, is a gonadotropin (FSH/LH) presented as an injectable powder for reconstitution for intramuscular or subcutaneous use. It is employed to stimulate ovarian follicular development and ovulation in women with specific reproductive disorders.
GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ferring Gmbh

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Indications & Clinical Uses

Menopur is a gonadotropin used in reproductive medicine to support follicular growth and ovulation.

  • Infertility due to anovulation: promotes follicular development to achieve ovulation in women who do not ovulate spontaneously.
  • Controlled ovarian stimulation for assisted reproductive technologies (e.g., IVF): enhances the number of mature oocytes retrieved for fertilisation.
  • Hypogonadotropic hypogonadism: replaces deficient endogenous gonadotropins to restore normal ovarian function.

How It Works

  • Menotrophin contains both follicle‑stimulating hormone (FSH) and luteinising hormone (LH) activity. After subcutaneous or intramuscular injection, it binds to FSH and LH receptors on granulosa and theca cells in the ovary, activating intracellular signaling pathways that stimulate follicular growth, estrogen production, and final oocyte maturation leading to ovulation.

Side Effects

Menopur may cause a range of adverse reactions, most of which are related to its hormonal activity and injection site.

Common Side Effects

  • Injection site pain or erythema: mild discomfort at the administration site.
  • Abdominal bloating or discomfort: transient gastrointestinal symptoms.
  • Mild ovarian hyperstimulation: enlarged ovaries with mild discomfort.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (OHSS): severe ovarian enlargement, fluid shift, and potential thromboembolic events.
  • Multiple pregnancy: increased risk of twins or higher-order gestations.
  • Allergic reaction: rash, urticaria, or anaphylaxis in rare cases.

Precautions & Warnings

Before initiating Menopur therapy, clinicians should assess patient suitability and monitor response closely.

  • Monitor ovarian response: perform ultrasound and estradiol measurements to adjust dosing.
  • Avoid use in pregnancy: the drug is intended for pre‑conception stimulation only.
  • Assess for hypersensitivity: discontinue if signs of allergic reaction appear.
  • Use caution in patients with ovarian cysts or a history of OHSS.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur may interact with other hormonal agents and medications that affect ovarian function.

Major Interactions (Avoid)

  • GnRH antagonists: can blunt the stimulatory effect of Menotrophin.
  • Oral contraceptives: suppress endogenous gonadotropins, reducing efficacy.
  • Hormonal therapies that suppress FSH/LH: may counteract Menopur action.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone replacement: altered metabolism may affect response.
  • Corticosteroids: may influence ovarian response and fluid balance.
  • Anticoagulants: monitor for bleeding if ovarian enlargement occurs.

Frequently Asked Questions

Menopur is a gonadotropin preparation containing menotrophin, which is used to stimulate ovarian follicular development and ovulation in women with infertility due to anovulation, to support controlled ovarian stimulation for assisted reproductive technologies such as in‑vitro fertilisation, and to treat hypogonadotropic hypogonadism.

Menotrophin provides both FSH and LH activity. After injection, it binds to FSH and LH receptors on ovarian granulosa and theca cells, activating signaling pathways that promote follicle growth, estrogen synthesis, and final oocyte maturation, thereby facilitating ovulation.

The dose of Menopur is individualized. A qualified prescriber determines the amount and frequency based on the patient’s ovarian response, treatment protocol, and clinical goals. Dosing regimens are not standardised and should follow the prescribing physician’s instructions.

Menopur is intended for use before conception to stimulate ovulation. Its safety in established pregnancy or while breastfeeding has not been established, and it is generally not recommended for use during these periods.

To order Menopur, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Menopur contains both FSH and LH activity, whereas some alternatives provide only FSH (e.g., follitropin alfa). The combined activity can be advantageous in certain protocols, but the choice depends on the individual’s response, treatment plan, and physician preference.

Menopur should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. After reconstitution, the solution should be used promptly according to the manufacturer’s instructions.

Menopur is supplied as a powder for reconstitution and is administered by subcutaneous or intramuscular injection. The reconstituted solution is drawn into a sterile syringe and injected according to the dosing schedule prescribed by the treating physician.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can cause severe ovarian enlargement, fluid shifts, and thromboembolic complications, as well as the possibility of multiple pregnancy and rare allergic reactions.

Menopur is contraindicated in women who are pregnant, have known hypersensitivity to menotrophin or any excipients, have ovarian cysts that could predispose to OHSS, or have uncontrolled endocrine disorders that could be exacerbated by gonadotropin therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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