Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotropin, the active ingredient in Menopur, is a gonadotropin presented as an injectable powder for solution for injection for intramuscular or subcutaneous administration. It provides exogenous FSH and LH activity to stimulate ovarian follicular development and estrogen production, supporting ovulation induction and controlled ovarian hyperstimulation in women with infertility.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and regulatory requirements across EU and global markets.

Manufacturer / TM Owner

Ferring Gmbh

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Indications & Clinical Uses

Menopur is a gonadotropin used in reproductive medicine to support follicular growth and ovulation.

  • Anovulation: induces ovulation in women with anovulatory infertility.
  • Controlled ovarian hyperstimulation: enhances follicular development for assisted reproductive technologies such as IVF.
  • Induction of ovulation in infertility treatment: facilitates ovulation in patients undergoing fertility therapy.

How It Works

  • Menotropin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) subunits. After subcutaneous or intramuscular injection, the FSH component binds to FSH receptors on granulosa cells, promoting follicular recruitment and growth, while the LH component activates LH receptors on theca cells, stimulating androgen production that is aromatized to estrogen. The combined activity mimics the natural pituitary gonadotropin surge, leading to follicular maturation and ovulation.

Side Effects

Menopur may be associated with a range of adverse reactions, which are generally related to its hormonal activity and injection site.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Abdominal bloating: transient abdominal distension.
  • Headache: mild headache episodes.
  • Nausea: occasional nausea.
  • Mood changes: mild emotional lability.
  • Ovarian hyperstimulation symptoms: mild ovarian enlargement.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (OHSS): severe fluid shift and thrombosis risk.
  • Multiple pregnancy: increased chance of twins or higher‑order gestations.
  • Thromboembolic events: rare blood clot formation.
  • Allergic reaction: anaphylaxis or severe hypersensitivity.

Precautions & Warnings

Prior to initiating Menopur therapy, clinicians should consider several precautionary measures to ensure patient safety.

  • Baseline assessment: perform ultrasound and hormone evaluation before treatment.
  • Ovarian monitoring: conduct regular ultrasound to detect excessive follicular response.
  • OHSS risk: assess patient history for risk factors such as polycystic ovary syndrome.
  • Pregnancy testing: confirm negative pregnancy test before starting therapy.
  • Concomitant hormones: avoid use with other gonadotropins unless medically indicated.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other medications that affect hormonal balance or coagulation.

Major Interactions (Avoid)

  • GnRH agonists/antagonists: may alter gonadotropin response if not coordinated.
  • Anticoagulants: increased risk of bleeding with severe OHSS.
  • Estrogen‑containing products: may interfere with intended hormonal stimulation.

Moderate Interactions (Monitor Closely)

  • Thyroid hormones: monitor thyroid function as gonadotropins can affect metabolism.
  • Corticosteroids: may mask OHSS symptoms.
  • Diuretics: can influence fluid balance during OHSS.

Frequently Asked Questions

Menopur is prescribed to treat infertility by stimulating ovarian follicular development. It is used for anovulation, controlled ovarian hyperstimulation in assisted reproductive technologies such as IVF, and for ovulation induction in women who have difficulty ovulating naturally.

Menotropin contains both FSH and LH activity. After injection, the FSH component promotes growth of ovarian follicles, while the LH component supports the conversion of androgens to estrogen. Together they mimic the natural pituitary surge, leading to mature follicles and ovulation.

The dose of Menopur is individualized. A qualified prescriber determines the amount and frequency based on the patient’s ovarian response, treatment protocol, and monitoring results. No fixed regimen is provided in public information.

Menopur is intended for use before pregnancy to achieve ovulation. Its safety during pregnancy has not been established, and it is generally not continued once pregnancy is confirmed. Limited data are available for breastfeeding, so use is usually avoided.

To order Menopur, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Menopur is a highly purified menotropin preparation containing both FSH and LH activity, whereas many alternatives, such as recombinant FSH products, provide only FSH. Menopur’s combined activity can reduce the need for additional LH supplementation, but dosing and response may differ between products.

Menopur should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. After reconstitution, the solution should be used promptly or stored according to the manufacturer’s instructions, typically within 24 hours at the same temperature.

Menopur is supplied as a sterile powder that must be reconstituted with the provided diluent. The resulting solution is injected subcutaneously or intramuscularly, usually in the abdominal wall or thigh, following the dosing schedule prescribed by the treating physician.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can cause severe fluid shifts and thromboembolic events, and the increased likelihood of multiple pregnancies. Prompt monitoring and early detection of symptoms are essential to mitigate these risks.

Menopur is contraindicated in individuals with known hypersensitivity to menotropin or any excipients, in women who are already pregnant, and in patients with uncontrolled thyroid disease or severe ovarian cysts. Caution is also advised for those with a history of thromboembolic disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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