Product image of Menopur (Menotrophin) supplied by GNH India

Menopur

Active Ingredient:
Menotrophin
Origin:
EU

Menopur (Menotrophin)

Menotrophin, the active ingredient in Menopur, is a gonadotropin presented as an injectable solution for intramuscular or subcutaneous use. It provides follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity to treat infertility caused by anovulation and to support assisted reproductive technologies in women.

GNH India supplies Menopur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Ferring Lægemidler A/S

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Indications & Clinical Uses

  • Menopur is used in reproductive medicine to stimulate follicular development and ovulation.
  • Infertility due to anovulation: promotes follicle growth and ovulation in women who do not ovulate spontaneously.
  • Controlled ovarian stimulation for assisted reproductive technologies (e.g., IVF): enables multiple follicle development to increase oocyte retrieval.
  • Induction of ovulation in women with hypogonadotropic hypogonadism: supplies necessary FSH/LH activity to trigger ovulation.

How It Works

  • Menotrophin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) in a fixed ratio. After subcutaneous or intramuscular injection, the hormones bind to their respective gonadotropin receptors on ovarian granulosa and theca cells, stimulating follicular maturation, estradiol production, and the LH surge that leads to ovulation.

Side Effects

Menopur may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Abdominal discomfort or bloating
  • Injection site pain, redness or swelling
  • Headache
  • Nausea or mild vomiting

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome (OHSS) with rapid weight gain, ascites or respiratory distress
  • Thromboembolic events such as deep‑vein thrombosis
  • Allergic reactions including rash, urticaria or anaphylaxis
  • Ovarian cyst rupture or hemorrhage

Precautions & Warnings

When prescribing Menopur, clinicians should observe several safety measures to minimize risks.

  • Monitor ovarian response: perform ultrasound and estradiol assessments regularly.
  • Assess risk of ovarian hyperstimulation syndrome: consider patient history and adjust dose accordingly.
  • Adjust dose based on individual response: titrate according to follicular growth and hormone levels.
  • Avoid use during pregnancy: discontinue if pregnancy occurs.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menopur can interact with other medications that affect hormonal balance or coagulation.

Major Interactions (Avoid)

  • Concomitant use with other gonadotropin preparations: may markedly increase risk of OHSS.
  • High‑dose estrogen therapy: can alter ovarian response and increase thrombotic risk.
  • Anticoagulant drugs (e.g., warfarin, direct oral anticoagulants): heightened bleeding risk if OHSS develops.

Moderate Interactions (Monitor Closely)

  • GnRH agonists or antagonists used in IVF protocols: may require dose adjustments.
  • Hormonal contraceptives taken during stimulation cycles: may affect follicular development and require timing changes.

Frequently Asked Questions

Menopur is a gonadotropin preparation used to stimulate follicular development and induce ovulation in women undergoing assisted reproductive techniques such as in‑vitro fertilisation, as well as in cases of anovulatory infertility and hypogonadotropic hypogonadism.

Menotrophin provides exogenous follicle‑stimulating hormone (FSH) and luteinizing hormone (LH). These hormones bind to their specific receptors on ovarian cells, promoting follicle growth, estradiol synthesis, and the LH surge that triggers ovulation, thereby supporting the reproductive cycle.

The dose of Menopur is individualized. A qualified prescriber determines the amount and frequency based on the patient’s ovarian response, hormone levels, body weight, and the specific assisted‑reproduction protocol being followed.

Menopur is not intended for use during an established pregnancy and its safety in pregnancy has not been established. Likewise, there is insufficient data on excretion in breast milk, so breastfeeding is generally not recommended while receiving the product.

To order Menopur, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling) and necessary import documentation.

Menopur contains both FSH and LH activity in a fixed ratio, whereas some alternatives such as recombinant FSH (e.g., follitropin alfa) provide only FSH. The combined activity of Menopur can be advantageous in patients who require both hormones for optimal follicular development, but the choice depends on individual clinical assessment.

Menopur must be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside this range.

Menopur is supplied as a sterile injectable solution. It is administered by a trained healthcare professional either intramuscularly or subcutaneously, typically using a fine‑gauge needle. The injection site and technique are chosen according to the treatment protocol and patient comfort.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can lead to rapid fluid accumulation, thromboembolic events, and, rarely, ovarian cyst rupture or hemorrhage. Prompt monitoring and dose adjustment are essential to mitigate these risks.

Menopur is contraindicated in women with known hypersensitivity to menotrophin or any excipients, in those with active ovarian cysts, uncontrolled thyroid disease, or severe ovarian hyperstimulation syndrome. It should also be avoided in pregnancy and is not recommended for use in patients with certain hormone‑dependent cancers.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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