Product image of Menotrophin Ferring-Léciva (Menotrophin) supplied by GNH India

Menotrophin Ferring-Léciva

Active Ingredient:
Menotrophin
Origin:
EU

Menotrophin Ferring-Léciva (Menotrophin)

Menotrophin, the active ingredient in Menotrophin Ferring‑Léciva, is a gonadotropin (FSH/LH mixture) presented as a sterile injectable solution for subcutaneous use. It is employed to treat infertility caused by anovulation and to support assisted reproductive technologies in women, including in vitro fertilisation cycles, by promoting follicular growth and ovulation.

GNH India supplies Menotrophin Ferring‑Léciva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance, regulatory compliance and reliable cold‑chain logistics for this biologic product.

Manufacturer / TM Owner

Ferring Léciva A.S.

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Indications & Clinical Uses

Menotrophin is used in reproductive endocrinology to stimulate ovarian follicular development and ovulation.

  • Infertility due to anovulation: stimulates follicular growth and induces ovulation in women who do not ovulate spontaneously.
  • Controlled ovarian stimulation for assisted reproductive technologies (e.g., IVF): supports development of multiple follicles to increase the number of retrievable oocytes.
  • Induction of ovulation in women with hypogonadotropic hypogonadism: provides necessary FSH and LH activity to trigger ovulation in patients with deficient gonadotropin secretion.

How It Works

  • Menotrophin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH). After subcutaneous injection, the FSH component binds to FSH receptors on ovarian granulosa cells, promoting follicle maturation and estradiol synthesis. The LH component activates LH receptors on theca and luteal cells, supporting androgen production and triggering the LH surge that culminates in ovulation. This coordinated hormonal stimulation restores the natural follicular phase and prepares the endometrium for potential implantation.

Side Effects

Menotrophin may be associated with several adverse reactions, ranging from mild to severe.

Common Side Effects

  • Injection site pain
  • Mild abdominal bloating
  • Nausea
  • Headache

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome
  • Multiple pregnancy
  • Allergic reaction or anaphylaxis
  • Thromboembolic events

Precautions & Warnings

When using Menotrophin, clinicians should observe specific precautions to minimise risks and ensure optimal outcomes.

  • Monitor ovarian response: perform ultrasound and estradiol assessments to adjust dose.
  • Avoid use in pregnancy: the drug is contraindicated once pregnancy is confirmed.
  • Assess for hypersensitivity: discontinue if signs of allergic reaction appear.
  • Use caution in patients with ovarian cysts: may exacerbate cyst growth.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menotrophin can interact with other medicines that affect hormonal balance or coagulation.

Major Interactions (Avoid)

  • Gonadotropin‑releasing hormone agonists or antagonists: may blunt the intended ovarian response.
  • Aromatase inhibitors: can reduce estrogen synthesis and diminish efficacy.
  • Anticoagulants: increased risk of thrombosis if ovarian hyperstimulation occurs.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: suppress endogenous gonadotropins and may require washout before treatment.
  • Thyroid hormone therapy: altered metabolism may affect drug activity.
  • Steroid medications: can influence ovarian response and require dose adjustment.

Frequently Asked Questions

Menotrophin Ferring‑Léciva is prescribed to stimulate ovarian follicular development and induce ovulation in women with infertility caused by anovulation, to support controlled ovarian stimulation for assisted reproductive technologies such as in‑vitro fertilisation, and to trigger ovulation in patients with hypogonadotropic hypogonadism.

The product contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH). After subcutaneous injection, FSH binds to receptors on granulosa cells to promote follicle growth and estrogen production, while LH activates theca‑cell receptors to support androgen synthesis and triggers the LH surge that leads to ovulation.

The exact dose and treatment schedule are individualized and set by the prescribing physician based on the patient’s ovarian response, underlying diagnosis, and the specific assisted‑reproduction protocol being used. No standard dosing can be provided without a medical assessment.

Menotrophin is intended for use before conception and is contraindicated once pregnancy is confirmed. Limited safety data are available for breastfeeding, and the drug is generally not recommended during lactation unless the benefit outweighs potential risk as assessed by a healthcare professional.

Enquiries are submitted via the product page on gnhindia.com. Provide the required quantity and institutional credentials; GNH India then contacts the buyer to confirm trade or procurement details, pricing, availability, shipping conditions (including cold‑chain if required) and any necessary import documentation.

Menotrophin is a combined FSH/LH preparation, whereas some alternatives contain only FSH (e.g., recombinant FSH) or only LH. The combined formulation can simplify dosing for protocols that require both hormones, but clinicians may choose a single‑component product based on individual patient response or specific protocol requirements.

Menotrophin must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. Vials should be kept in their original packaging until use and discarded after the recommended in‑use period once removed from refrigeration.

The medication is given by subcutaneous injection, typically into the abdomen or thigh. Healthcare professionals should follow aseptic technique, use the appropriate needle size, and rotate injection sites to minimise local irritation. Patients should be trained on self‑administration if required by the treatment plan.

The most serious adverse events include ovarian hyperstimulation syndrome (OHSS), which can be severe and require hospitalisation, multiple pregnancy, thromboembolic complications, and severe allergic reactions such as anaphylaxis. Prompt medical evaluation is essential if any of these signs appear.

Menotrophin is contraindicated in women who are already pregnant, have known hypersensitivity to any component of the formulation, or have uncontrolled thyroid disease, active ovarian cysts, or severe ovarian failure where stimulation would be ineffective. A thorough medical assessment is required before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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