Product image of Menotrophin Ferring (Menotrophin) supplied by GNH India

Menotrophin Ferring

Active Ingredient:
Menotrophin
Origin:
EU

Menotrophin Ferring (Menotrophin)

Menotropin, the active ingredient in Menotrophin Ferring, is a gonadotropin presented as a sterile solution for intramuscular and subcutaneous use. It provides exogenous FSH and LH activity to stimulate ovarian follicular development in women and support spermatogenesis in men with certain infertility disorders.

GNH India supplies Menotrophin Ferring as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ferring N.V.

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Indications & Clinical Uses

Menotrophin is a gonadotropin used in reproductive medicine to stimulate follicular development and spermatogenesis.

  • Induction of ovulation in women with anovulation: promotes follicular growth to enable ovulation.
  • Ovarian stimulation for assisted reproductive technology (e.g., IVF): enhances multiple follicle development for egg retrieval.
  • Stimulation of spermatogenesis in men with hypogonadotropic hypogonadism: provides LH and FSH activity to support sperm production.

How It Works

  • Menotrophin contains equal amounts of follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) derived from the urine of post‑menopausal women. After subcutaneous or intramuscular injection, the FSH component binds to FSH receptors on ovarian granulosa cells, stimulating follicular growth, while the LH component activates LH receptors on theca cells and Leydig cells, promoting steroidogenesis and supporting luteal phase or spermatogenesis. The combined activity mimics natural pituitary gonadotropins.

Side Effects

Menotrophin may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Injection site pain: mild discomfort or redness at the injection site.
  • Headache: transient headache of varying intensity.
  • Nausea: occasional feeling of nausea.
  • Abdominal discomfort: mild pelvic or abdominal pain.
  • Ovarian hyperstimulation symptoms: mild abdominal bloating or mild weight gain.
  • Gynecomastia in men: breast tenderness or enlargement.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (OHSS): severe abdominal pain, ascites, thromboembolism.
  • Multiple pregnancy: increased risk of twins or higher‑order gestations.
  • Allergic reaction: rash, urticaria, or anaphylaxis.
  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.

Precautions & Warnings

Before using Menotrophin, consider the following precautions to ensure safe and effective treatment.

  • Pregnancy testing: confirm non‑pregnant status before initiating therapy.
  • Ovarian monitoring: perform regular ultrasound to assess follicular response.
  • Hormone levels: check baseline FSH, LH, estradiol, and testosterone as appropriate.
  • Thromboembolic risk: evaluate history of clotting disorders before treatment.
  • Allergies: avoid use if known hypersensitivity to Menotrophin or its excipients.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menotrophin can interact with other medicines; awareness of major and moderate interactions helps manage risk.

Major Interactions (Avoid)

  • GnRH antagonists: may blunt the intended gonadotropin response.
  • High‑dose estrogen therapy: can suppress endogenous gonadotropin activity.
  • Anticoagulants: increased risk of bleeding with ovarian hyperstimulation.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may require washout period before starting Menotrophin.
  • Thyroid hormones: altered metabolism may affect reproductive hormone balance.
  • Steroids (e.g., prednisone): may influence follicular development.

Frequently Asked Questions

Menotrophin is prescribed to treat infertility. It is used to induce ovulation in women who do not ovulate spontaneously, to stimulate the ovaries during assisted reproductive techniques such as in‑vitro fertilisation, and to promote spermatogenesis in men with hypogonadotropic hypogonadism.

Menotropin contains both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH). After injection, the FSH component stimulates growth of ovarian follicles, while the LH component supports steroid production and luteal phase function. In men, the combined hormones act on the testes to encourage sperm production.

The dose of Menotrophin is individualized. A qualified prescriber determines the amount, frequency and duration of treatment based on the patient’s specific condition, response to therapy and monitoring results. No standard dosing regimen is provided in public information.

Menotrophin is not intended for use during an established pregnancy, and its safety in pregnancy has not been established. It is also not recommended for breastfeeding mothers because the effects on the infant are unknown. Patients should discuss any concerns with their healthcare provider.

To order Menotrophin Ferring, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Menotrophin provides both FSH and LH activity in a single preparation, whereas many newer products offer recombinant FSH or LH alone. The combined formulation can simplify dosing for protocols that require both hormones, but recombinant preparations may have higher purity and lower risk of immunogenicity. Choice of product depends on clinical protocol, patient response and physician preference.

Menotrophin must be stored in a refrigerator at 2‑8 °C (36‑46 °F). It should be kept in its original packaging, protected from light, and must not be frozen or shaken. If the product reaches room temperature for a short period, it may be used, but it should be returned to refrigerated conditions promptly.

Menotrophin is given by subcutaneous or intramuscular injection. The injection site should be rotated to minimise irritation. Healthcare professionals typically reconstitute the powder with the supplied diluent before administration, following aseptic technique and the prescribing information for the exact volume and concentration.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can cause severe abdominal pain, fluid accumulation and thromboembolic events, and the increased chance of multiple pregnancy. Rarely, allergic reactions such as anaphylaxis may occur. Patients should be monitored closely for these complications.

Menotrophin is contraindicated in women who are already pregnant, have known hypersensitivity to the product or its excipients, or have uncontrolled thyroid disease. Men with severe hypogonadism unrelated to pituitary deficiency, uncontrolled endocrine disorders, or a history of thromboembolic disease should also avoid its use unless specifically advised by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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