Product image of Menotrophin Ferring (Menotrophin) supplied by GNH India

Menotrophin Ferring

Active Ingredient:
Menotrophin
Origin:
EU

Menotrophin Ferring (Menotrophin)

Menotrophin, the active ingredient in Menotrophin Ferring, is a human menopausal gonadotropin (hMG) presented as an injectable solution for intramuscular or subcutaneous use. It provides exogenous FSH and LH activity to stimulate ovarian follicular development and ovulation in women with infertility.

GNH India supplies Menotrophin Ferring as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Ferring Gmbh

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Indications & Clinical Uses

Menotrophin is used in reproductive medicine to support follicular growth and ovulation.

  • Infertility due to anovulation: facilitates follicular development and induces ovulation in women who do not ovulate spontaneously.
  • Controlled ovarian hyperstimulation: enhances response to stimulation protocols for egg retrieval in assisted reproduction cycles.
  • Assisted reproductive technology (ART) procedures: provides necessary gonadotropin support during in‑vitro fertilisation (IVF) and related techniques.

How It Works

  • Menotrophin contains both follicle‑stimulating hormone (FSH) and luteinising hormone (LH) extracted from the urine of postmenopausal women. After intramuscular or subcutaneous injection, the FSH component binds to FSH receptors on ovarian granulosa cells, promoting follicle maturation, while the LH component activates LH receptors on theca cells, supporting steroidogenesis and final follicular maturation leading to ovulation.

Side Effects

Menotrophin may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Headache: transient headache of varying intensity.
  • Nausea: occasional nausea without vomiting.
  • Abdominal bloating: mild abdominal distension.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (OHSS): potentially severe fluid shift and ovarian enlargement.
  • Multiple pregnancy: increased risk of twins or higher‑order gestations.
  • Allergic reaction: rare anaphylaxis or hypersensitivity at the injection site.

Precautions & Warnings

Before prescribing Menotrophin, clinicians should consider the following precautions.

  • Patient selection: assess ovarian reserve and baseline hormone levels to tailor therapy.
  • Monitoring: perform regular ultrasound and estradiol measurements to detect excessive response.
  • Thromboembolic risk: evaluate history of clotting disorders as gonadotropin therapy may increase risk.
  • Pregnancy testing: confirm absence of pregnancy before initiating treatment.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menotrophin can interact with other medications that affect ovarian response or hormone levels.

Major Interactions (Avoid)

  • GnRH agonists used for down‑regulation: may amplify ovarian response leading to OHSS.
  • Estrogen‑containing contraceptives: can blunt the intended gonadotropin effect.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin): increased risk of ovarian cyst‑related bleeding.
  • Thyroid hormone therapy: altered metabolism may affect gonadotropin activity.
  • Corticosteroids: may modify ovarian response and require dose adjustment.

Frequently Asked Questions

Menotrophin Ferring is a fertility medication that contains both FSH and LH activity. It is prescribed to women who have difficulty ovulating, to stimulate controlled ovarian hyperstimulation in preparation for egg retrieval, and to provide gonadotropin support during assisted reproductive technology procedures such as in‑vitro fertilisation.

Menotrophin supplies exogenous follicle‑stimulating hormone (FSH) and luteinising hormone (LH). After injection, FSH binds to receptors on ovarian granulosa cells, promoting the growth and maturation of follicles, while LH activates theca‑cell receptors, supporting estrogen production and final follicular maturation, ultimately leading to ovulation.

The dosage of Menotrophin is individualized and determined by the treating physician based on the patient’s ovarian reserve, response to prior stimulation, and the specific assisted reproduction protocol. The prescriber will calculate the appropriate number of international units (IU) per injection and the duration of treatment.

Menotrophin is intended for use before conception to induce ovulation; it is not administered during an established pregnancy. Safety data for use while breastfeeding are limited, and the medication is generally avoided in lactating women unless the benefits outweigh potential risks as assessed by a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed) and any required import documentation.

Menotrophin is a human menopausal gonadotropin (hMG) that provides both FSH and LH activity in a single preparation, whereas recombinant FSH products contain only FSH. The combined activity can be advantageous in certain protocols, reducing the need for separate LH supplementation, but the choice depends on individual patient characteristics and clinician preference.

Menotrophin should be stored refrigerated between 2 °C and 8 °C. It must be kept in its original packaging, protected from light, and should not be frozen or shaken. If the product reaches room temperature, it should be used promptly and not be re‑refrigerated.

Menotrophin is supplied as a sterile injectable solution for intramuscular or subcutaneous injection. The medication is reconstituted with the appropriate diluent, drawn into a syringe, and administered according to the dosing schedule prescribed by the treating physician, typically in the abdomen or thigh.

The most serious adverse events include ovarian hyperstimulation syndrome (OHSS), which can cause rapid ovarian enlargement, fluid shifts, and thromboembolic complications, and the possibility of multiple pregnancy, which carries higher obstetric risk. Prompt monitoring and dose adjustment are essential to mitigate these risks.

Menotrophin is contraindicated in women with known hypersensitivity to any component of the product, active ovarian cysts, uncontrolled thyroid disease, or severe ovarian hyperstimulation syndrome. It should also be avoided in patients with a history of thromboembolic disorders unless a specialist determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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