Product image of Menotrophin Ferring (Menotrophin) supplied by GNH India

Menotrophin Ferring

Active Ingredient:
Menotrophin
Origin:
EU

Menotrophin Ferring (Menotrophin)

Menotrophin, the active ingredient in Menotrophin Ferring, is a human menopausal gonadotropin (hMG) presented as an injectable solution for subcutaneous administration. It provides combined follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity to stimulate ovarian follicle development and induce ovulation in women with infertility due to anovulation or for controlled ovarian hyperstimulation in assisted reproductive technology cycles.

GNH India supplies Menotrophin Ferring as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved product for global distribution.

Manufacturer / TM Owner

Ferring N.V.

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Indications & Clinical Uses

Menotrophin is used in fertility treatment to stimulate the ovarian follicular pathway.

  • Anovulatory infertility: promotes follicular growth and ovulation in women who do not ovulate spontaneously.
  • Controlled ovarian hyperstimulation for ART: enhances multiple follicle development to increase oocyte yield in IVF/ICSI cycles.
  • Assisted reproductive technology cycles: supports synchronized follicular development for embryo transfer procedures.

How It Works

  • Menotrophin contains purified preparations of both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) derived from human menopausal gonadotropin. After subcutaneous injection, the FSH component binds to FSH receptors on granulosa cells, stimulating follicular recruitment and estrogen production, while the LH component activates LH receptors on theca cells and mature follicles, triggering ovulation. The combined activity mimics the natural pituitary gonadotropin surge, facilitating oocyte maturation.

Side Effects

Menotrophin may cause a range of adverse reactions, which are generally related to its hormonal activity and injection site.

Common Side Effects

  • Injection site pain: mild discomfort at the injection site.
  • Headache: transient headache episodes.
  • Nausea: occasional nausea after dosing.
  • Abdominal discomfort: mild bloating or cramping.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (OHSS): severe fluid accumulation, abdominal pain, or respiratory distress.
  • Multiple pregnancy: increased chance of twins or higher-order gestations.
  • Allergic reaction: rash, urticaria, or anaphylaxis.

Precautions & Warnings

When using Menotrophin, clinicians should consider several precautionary measures to minimize risks and ensure optimal outcomes.

  • Assess baseline ovarian reserve: evaluate antral follicle count and AMH levels before initiating therapy.
  • Monitor estradiol levels: frequent serum estradiol measurements to detect excessive response.
  • Ultrasound monitoring: perform serial transvaginal ultrasounds to track follicle growth and detect OHSS early.
  • Adjust dose in high responders: reduce or discontinue treatment if rapid follicular development occurs.
  • Contraindications: avoid use in pregnancy, active ovarian cysts, or uncontrolled thyroid disease.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menotrophin may interact with other medications or substances that affect hormonal balance or ovarian response.

Major Interactions (Avoid)

  • Gonadotropin‑releasing hormone (GnRH) antagonists: may blunt the intended ovarian stimulation.
  • Aromatase inhibitors: can alter estrogen feedback and reduce efficacy.
  • High‑dose estrogen therapy: may interfere with follicular development.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: increased risk of ovarian hemorrhage during stimulation.
  • Thyroid hormone replacement: requires monitoring of thyroid status as gonadotropins can affect metabolism.
  • Corticosteroids: may modify ovarian response and fluid balance.

Frequently Asked Questions

Menotrophin is a fertility agent indicated for women with infertility due to anovulation and for controlled ovarian hyperstimulation in assisted reproductive technology (ART) cycles such as in vitro fertilisation. It helps develop multiple ovarian follicles and triggers ovulation to increase the chance of successful conception.

Menotrophin provides both follicle‑stimulating hormone (FSH) and luteinizing hormone (LH) activity. The FSH component stimulates granulosa cells to recruit and grow ovarian follicles, while the LH component supports theca cell function and triggers the final maturation and release of the oocyte, mimicking the natural pituitary surge.

The dosage of Menotrophin is individualized and set by the prescribing clinician based on the patient’s ovarian reserve, response to prior stimulation, and treatment protocol. The prescriber determines the amount, frequency, and duration of injections to achieve the desired follicular development.

Menotrophin is not intended for use during an established pregnancy and should be discontinued once pregnancy is confirmed. Its safety in breastfeeding has not been established, and the medication is generally avoided while nursing. Women should discuss any concerns with their healthcare provider.

To order Menotrophin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The team then replies with pricing, availability, shipping details (including cold‑chain if required) and any necessary import documentation.

The primary alternative to Menotrophin is recombinant follicle‑stimulating hormone (rFSH) such as follitropin alfa. While rFSH provides pure FSH activity, Menotrophin supplies a combination of FSH and LH, which may be advantageous in patients who benefit from LH support. Choice depends on individual response, protocol design and physician preference.

Menotrophin must be stored at 2‑8 °C (refrigerated). Keep the vials in their original packaging, protect them from light, and do not freeze or shake the solution. Once reconstituted, use the preparation within the time frame specified by the manufacturer and maintain the cold‑chain during transport.

Menotrophin is administered as a subcutaneous injection. The lyophilized powder is reconstituted with the supplied diluent, and the resulting solution is drawn into a sterile syringe. Injections are typically given in the abdominal wall or thigh, following the dosing schedule prescribed by the treating physician.

The most serious risks associated with Menotrophin include ovarian hyperstimulation syndrome (OHSS), which can cause severe abdominal pain, fluid accumulation and respiratory compromise; multiple pregnancy, which raises obstetric complications; and rare allergic reactions such as anaphylaxis. Prompt medical attention is required if any of these occur.

Menotrophin is contraindicated in women who are already pregnant, have active ovarian cysts, uncontrolled thyroid disease, severe ovarian hyperstimulation syndrome, or known hypersensitivity to any component of the product. It should also be used with caution in patients with a history of thromboembolic disorders or ovarian torsion.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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