Product image of Menotrophin Ferring (Menotrophin) supplied by GNH India

Menotrophin Ferring

Active Ingredient:
Menotrophin
Origin:
EU

Menotrophin Ferring (Menotrophin)

Menotrophin, the active ingredient in Menotrophin Ferring, is a Gonadotropin (FSH/LH) preparation presented as a subcutaneous injectable for use in reproductive hormone therapy. It is used to stimulate follicular development and ovulation in women with anovulatory infertility and in assisted reproductive technology cycles.

GNH India supplies Menotrophin Ferring as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, fertility clinics and pharmacies worldwide.

Manufacturer / TM Owner

Ferring Gmbh

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Indications & Clinical Uses

Menotrophin is employed in reproductive endocrinology to promote follicular growth and ovulation in several clinical scenarios.

  • Anovulatory infertility: induces follicular development and ovulation in women who do not ovulate spontaneously.
  • In vitro fertilisation (IVF) cycles: supports controlled ovarian stimulation to obtain multiple mature oocytes.
  • Polycystic ovary syndrome (PCOS) ovulation induction: facilitates follicular maturation and timed ovulation.

How It Works

  • Menotrophin provides exogenous follicle‑stimulating hormone (FSH) and luteinising hormone (LH) activity, binding to their respective receptors on ovarian granulosa and theca cells. This activation stimulates aromatase activity, estradiol synthesis, and the maturation of ovarian follicles, ultimately leading to ovulation. The combined FSH/LH effect mimics the natural pituitary gonadotropin surge required for follicular development and luteinisation.

Side Effects

Menotrophin may cause a range of adverse reactions, most of which are related to its hormonal activity and injection route.

Common Side Effects

  • Injection site pain or erythema: mild discomfort at the subcutaneous site.
  • Nausea or abdominal discomfort: transient gastrointestinal upset.
  • Headache: mild to moderate intensity.
  • Mild ovarian hyperstimulation: enlarged ovaries without severe symptoms.
  • Mood changes: irritability or emotional lability.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (severe): rapid weight gain, ascites, or respiratory distress.
  • Multiple pregnancy: increased risk of twins or higher-order gestations.
  • Allergic reaction or anaphylaxis: rash, swelling, or breathing difficulty.
  • Thromboembolic events: rare clot formation.
  • Ectopic pregnancy: implantation outside the uterine cavity.

Precautions & Warnings

Before initiating Menotrophin therapy, clinicians should consider several safety measures.

  • Monitor ovarian response: use serial ultrasound and estradiol measurements.
  • Avoid use in known hypersensitivity: discontinue if allergic signs appear.
  • Assess pituitary function: ensure adequate endogenous gonadotropin reserve.
  • Use caution with ovarian cysts: evaluate size and risk before stimulation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menotrophin can interact with other hormonal agents and medications that affect ovarian response.

Major Interactions (Avoid)

  • GnRH agonists: may increase risk of severe ovarian hyperstimulation.
  • hCG therapy: can exacerbate ovarian response and heighten hyperstimulation risk.
  • Estrogen‑containing contraceptives: may diminish Menotrophin efficacy.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: monitor for bleeding if ovarian cyst rupture occurs.
  • Thyroid hormone therapy: observe thyroid function as hormonal shifts may occur.
  • Corticosteroids: may alter hormone metabolism and affect response.

Frequently Asked Questions

Menotrophin Ferring is a gonadotropin preparation containing both FSH and LH activity. It is used to stimulate follicular development and induce ovulation in women with anovulatory infertility and to support controlled ovarian stimulation in assisted reproductive technology procedures such as in‑vitro fertilisation.

Menotrophin supplies exogenous follicle‑stimulating hormone (FSH) and luteinising hormone (LH). These hormones bind to their specific receptors on ovarian cells, promoting estradiol production, follicle maturation, and the final LH surge that triggers ovulation, thereby mimicking the natural pituitary signal.

The dose of Menotrophin is individualized. A qualified prescriber determines the amount, frequency, and duration based on the patient’s ovarian response, treatment protocol, and clinical goals. Dosing regimens are not standardized and should follow the prescribing physician’s instructions.

Menotrophin is intended for use before conception to achieve ovulation. Its safety in established pregnancy has not been established, and it is generally not recommended during pregnancy. Limited data exist for breastfeeding; therefore, use while nursing should be discussed with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Menotrophin combines FSH and LH activity in a single preparation, whereas many alternatives provide only FSH (e.g., recombinant FSH) and require separate LH supplementation if needed. This dual action can simplify dosing schedules but may carry a slightly higher risk of ovarian hyperstimulation compared with pure FSH products.

Menotrophin should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Vials should remain in their original packaging until use to maintain stability and potency.

Menotrophin is given by subcutaneous injection, typically into the abdominal wall or thigh. The injection site should be rotated with each dose, and aseptic technique must be followed. Patients are usually instructed by a healthcare professional on proper reconstitution and administration.

The most serious risks include severe ovarian hyperstimulation syndrome, which can cause rapid weight gain, fluid accumulation, and respiratory compromise, and the possibility of multiple pregnancy. Rarely, allergic reactions or thromboembolic events may occur, requiring immediate medical attention.

Menotrophin is contraindicated in individuals with known hypersensitivity to any of its components, in patients with uncontrolled ovarian cysts, or in those with pituitary disorders that impair gonadotropin regulation. It should also be avoided in women who are currently pregnant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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