Product image of Mentifar (Memantine Hydrochloride) supplied by GNH India

Mentifar

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Mentifar (Memantine Hydrochloride)

Memantine, the active ingredient in Mentifar, is a NMDA receptor antagonist presented as an oral tablet for oral use. It is used to treat moderate to severe Alzheimer’s disease in adult patients.
GNH India supplies Mentifar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

Mentifar is a NMDA receptor antagonist indicated for the management of Alzheimer’s disease, where it helps to improve cognition and functional abilities.

  • Alzheimer’s disease (moderate to severe): supports modest improvements in memory, reasoning and daily activities.

How It Works

  • Memantine acts as a non‑competitive antagonist at the NMDA (N‑methyl‑D‑aspartate) receptor. By binding to the receptor-associated ion channel at a site distinct from the glutamate binding site, it reduces excessive calcium influx caused by overstimulation, thereby limiting excitotoxic neuronal injury that contributes to cognitive decline in Alzheimer’s disease.

Side Effects

Common Side Effects

  • Dizziness: transient light‑headedness reported by some patients.
  • Headache: mild to moderate intensity.
  • Constipation: reduced bowel movements.
  • Fatigue: feeling of tiredness.
  • Hypertension: occasional increase in blood pressure.
  • Confusion: occasional episodes of mental clouding.

Serious or Rare Side Effects

  • Seizures: rare but may occur, especially at high plasma levels.
  • Allergic reactions: rash, pruritus, or angioedema.
  • Hepatic dysfunction: elevated liver enzymes.
  • Stevens‑Johnson syndrome: extremely rare severe skin reaction.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Renal impairment: assess kidney function and adjust dose if needed.
  • Hepatic disease: monitor liver enzymes regularly.
  • Cardiovascular disorders: watch for blood pressure changes.
  • Concomitant CNS depressants: may increase dizziness or sedation.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk, as safety data are limited.
  • Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Memantine may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

  • Amantadine: additive CNS effects may increase confusion.
  • Ketamine: combined NMDA antagonism can exacerbate neuropsychiatric symptoms.
  • Other NMDA antagonists: risk of excessive blockade.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypotensive effects.
  • Antihypertensives: additive blood pressure lowering.
  • CNS depressants (e.g., benzodiazepines): may increase sedation and dizziness.

Frequently Asked Questions

Mentifar contains memantine hydrochloride and is prescribed for the treatment of moderate to severe Alzheimer’s disease. It helps to improve cognitive function and daily living activities by reducing neuronal excitotoxicity associated with the disease.

Memantine works as a non‑competitive antagonist of the NMDA receptor. By blocking the receptor’s ion channel, it limits excessive calcium entry caused by overstimulation with glutamate, thereby protecting neurons from excitotoxic damage that contributes to cognitive decline.

The dosage of Mentifar is determined by the prescribing clinician based on the patient’s clinical condition, renal function and tolerability. Physicians typically start with a low dose and titrate upward as needed, following approved prescribing information.

Safety data for memantine in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order Mentifar, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mentifar (memantine) belongs to the NMDA receptor antagonist class, differing from cholinesterase inhibitors such as donepezil. While cholinesterase inhibitors increase acetylcholine levels, memantine reduces glutamate‑mediated excitotoxicity. The choice of therapy depends on disease stage, patient tolerance and physician assessment.

Mentifar should be stored below 25 °C in a dry place. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Mentifar is taken orally, usually once daily with or without food, as directed by the prescribing physician. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious risks include the potential for seizures, severe allergic reactions such as rash or angioedema, and rare but life‑threatening skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Mentifar is contraindicated in patients with known hypersensitivity to memantine or any component of the formulation. Caution is also advised for individuals with severe renal impairment, uncontrolled hypertension, or those taking other NMDA antagonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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