Product image of Menveo (Meningococcal Group Y Oligosaccharide Conjugated To Corynebacterium Diphtheriae Crm197 Protein, N. M) supplied by GNH India

Menveo

Active Ingredient:
Meningococcal Group Y Oligosaccharide Conjugated To Corynebacterium Diphtheriae Crm197 Protein, N. M
Origin:
EU

Menveo (Meningococcal Group Y Oligosaccharide Conjugated To Corynebacterium Diphtheriae Crm197 Protein, N. M)

Meningococcal Group Y Oligosaccharide Conjugated To Corynebacterium Diphtheriae Crm197 Protein, the active ingredient in Menveo, is a vaccine presented as a 0.5 mL vial (lyophilized powder for suspension) for intramuscular use. It induces protective immunity against invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, W‑135 and Y in at‑risk populations, including children, adolescents and adults.

GNH India supplies Menveo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality, regulatory compliance and reliable cold‑chain logistics across global markets.

Manufacturer / TM Owner

Gsk Vaccines S.R.L.

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Indications & Clinical Uses

Menveo is a conjugate vaccine targeting the capsular polysaccharides of Neisseria meningitidis and is used for prevention of meningococcal disease.

  • Invasive meningococcal disease (serogroups A, C, W‑135, Y): Provides active immunity to reduce the risk of infection.
  • Adolescents and young adults: Lowers incidence of meningococcal disease in high‑risk age groups.
  • Travelers to endemic regions: Offers protection against meningococcal infection during international travel.

How It Works

  • Menveo contains polysaccharides from Neisseria meningitidis serogroups A, C, W‑135 and Y covalently linked to the non‑toxoid protein carrier CRM197. The conjugate format enables a T‑cell‑dependent response, prompting B‑cells to produce high‑affinity, long‑lasting antibodies against the bacterial capsular polysaccharides, and generates memory B‑cells for rapid protection upon exposure.

Side Effects

Common and serious adverse reactions have been reported following Menveo administration.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or swelling: localized erythema or edema.
  • Fever: transient elevation of body temperature.
  • Headache: mild headache occurring within 24 hours.
  • Fatigue: temporary feeling of tiredness.
  • Muscle aches: mild myalgia around the injection area.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Guillain‑Barré syndrome: rare neurologic disorder reported post‑vaccination.
  • Seizures: infrequent occurrence, especially in febrile children.
  • Hypotension: sudden drop in blood pressure after injection.
  • Meningococcal disease despite vaccination: extremely rare breakthrough infection.

Precautions & Warnings

Before administering Menveo, consider the following precautions and warnings.

  • Pregnancy: safety not established; vaccinate only if benefit outweighs risk.
  • Immunocompromised patients: vaccine may elicit a reduced immune response.
  • Known allergy: avoid if hypersensitivity to any vaccine component, including CRM197.
  • Fever monitoring: observe for fever or systemic reactions after injection.
  • Concurrent vaccines: can be given at separate sites; follow recommended intervals.
  • Storage: Store at 2‑8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menveo may interact with other medicines or biologics; consider the following.

Major Interactions (Avoid)

  • Live bacterial vaccines: avoid simultaneous administration as immune response may be impaired.
  • Immunoglobulin therapy: may diminish vaccine efficacy if given concurrently.

Moderate Interactions (Monitor Closely)

  • Antipyretics (e.g., acetaminophen): may mask post‑vaccination fever, monitor temperature.
  • Other vaccines: schedule appropriately to avoid interference with immune response.
  • Immunosuppressive drugs: monitor antibody levels as response may be attenuated.
  • Blood products: consider timing to prevent reduced immunogenicity.

Frequently Asked Questions

Menveo is a conjugate vaccine indicated for the prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, W‑135 and Y. It is administered to individuals at risk, including children, adolescents, adults, and travelers to endemic areas.

The active ingredient consists of polysaccharides from four meningococcal serogroups chemically linked to the CRM197 protein carrier. This conjugation creates a T‑cell‑dependent immune response, stimulating B‑cells to produce high‑affinity antibodies and memory cells that protect against future infection.

The dosing schedule for Menveo is determined by the prescribing healthcare professional based on age, risk factors and local immunization guidelines. The vaccine is supplied as a lyophilized powder that must be reconstituted and given as a single intramuscular injection per the prescriber's instructions.

Safety data for Menveo in pregnant or breastfeeding individuals are limited. The vaccine should only be administered during pregnancy if the potential benefit justifies any possible risk, and healthcare providers should discuss individual circumstances with the patient.

To order Menveo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.

Menveo is a quadrivalent conjugate vaccine covering serogroups A, C, W‑135 and Y, similar to other products such as Nimenrix or Menactra. All use a protein carrier to enhance immunogenicity, but differences may exist in carrier protein, dosing schedule, and regulatory approvals in specific regions.

Menveo must be stored refrigerated at 2 °C to 8 °C. It should be kept in its original packaging, protected from light, and must never be frozen or shaken. After reconstitution, the suspension should be used immediately and discarded if not used within the recommended time.

Menveo is supplied as a lyophilized powder that is reconstituted with the provided diluent to form a clear suspension. The vaccine is then administered as a single intramuscular injection, typically in the deltoid muscle, by a qualified healthcare professional.

Serious adverse events reported with Menveo include anaphylaxis, Guillain‑Barré syndrome, seizures (especially in febrile children), severe hypotension, and, rarely, breakthrough meningococcal disease despite vaccination. Any signs of severe allergic reaction or neurologic symptoms should be evaluated promptly.

Menveo is contraindicated in individuals with a known severe allergy to any component of the vaccine, including the CRM197 carrier protein. Persons who have experienced a previous severe reaction to a meningococcal conjugate vaccine should also avoid further doses.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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