Product image of Mepires (Clarithromycin) supplied by GNH India

Mepires

Active Ingredient:
Clarithromycin
Origin:
EU

Mepires (Clarithromycin)

Clarithromycin, the active ingredient in Mepires, is a macrolide antibiotic presented as a strength/form for oral use. It treats bacterial infections such as community‑acquired pneumonia, acute sinusitis, bronchitis exacerbations, skin infections and is part of Helicobacter pylori eradication regimens.
GNH India supplies Mepires as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sja Pharm Ltd

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Indications & Clinical Uses

Clarithromycin is a macrolide antibiotic used to treat bacterial infections of the respiratory, skin and gastrointestinal systems.

  • Community‑acquired pneumonia: effective eradication of the causative bacteria and improvement of clinical outcomes.
  • Acute bacterial sinusitis: reduces infection and relieves sinus inflammation.
  • Acute bacterial exacerbations of chronic bronchitis: controls bacterial overgrowth and improves breathing.
  • Skin and soft‑tissue infections: targets susceptible organisms to resolve infection.
  • Helicobacter pylori eradication regimens: used in combination therapy to eliminate H. pylori infection.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting the translocation step of protein synthesis. This prevents peptide chain elongation, halting bacterial growth and leading to a bacteriostatic effect against susceptible Gram‑positive and some Gram‑negative organisms.

Side Effects

Common side effects are generally mild and transient.

Common Side Effects

  • Nausea
  • Diarrhea
  • Abdominal discomfort
  • Altered taste

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Clostridioides difficile‑associated colitis
  • QT interval prolongation

Precautions & Warnings

Before prescribing clarithromycin, consider the following precautions.

  • Liver function: assess hepatic status, as the drug is metabolized hepatically.
  • Cardiac risk: monitor QT interval in patients with known cardiac disease or electrolyte disturbances.
  • Allergy: avoid in individuals with a known macrolide hypersensitivity.
  • Renal impairment: adjust therapy in severe renal dysfunction.
  • Drug interactions: review concomitant medications that affect CYP3A4 or QT interval.
  • Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Clarithromycin can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Co‑administration with other QT‑prolonging agents (e.g., quinolones, antiarrhythmics) may increase arrhythmia risk.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) can raise clarithromycin plasma levels.
  • Ergot derivatives may cause ergot toxicity when combined.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect; monitor INR regularly.
  • CYP3A4‑metabolized statins (e.g., simvastatin): increased risk of myopathy; consider dose adjustment or alternative statin.

Frequently Asked Questions

Mepires, containing clarithromycin, is indicated for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, acute exacerbations of chronic bronchitis, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication.

Clarithromycin binds to the 50S ribosomal subunit of susceptible bacteria, blocking the translocation step of protein synthesis. This inhibition prevents peptide chain elongation, resulting in a bacteriostatic effect that limits bacterial growth and helps the immune system clear the infection.

The specific dose and schedule of clarithromycin are determined by the prescribing clinician based on the infection type, severity, patient age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions precisely.

Clarithromycin is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are limited human data. It may be used during pregnancy if the benefit outweighs potential risk. Small amounts are excreted in breast milk; clinicians should weigh benefits against possible effects on the infant.

To order Mepires, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Clarithromycin shares the macrolide class with azithromycin and erythromycin but has a longer half‑life, allowing twice‑daily dosing, and a broader spectrum against certain atypical pathogens. It is more potent against Haemophilus influenzae and Mycoplasma pneumoniae, though it may have a higher potential for drug‑drug interactions via CYP3A4.

Mepires should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct light. Maintaining these conditions helps preserve the drug’s stability and potency throughout its shelf life.

Mepires is administered orally, typically as tablets or capsules, and should be taken with or without food as directed by the prescriber. The full course should be completed even if symptoms improve, to ensure eradication of the infection.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and QT interval prolongation that can lead to cardiac arrhythmias. Patients should seek immediate medical attention if they experience rash, persistent diarrhea, or symptoms of irregular heartbeat.

Clarithromycin is contraindicated in individuals with a known hypersensitivity to macrolide antibiotics, those with a history of significant QT prolongation, and patients taking certain contraindicated drugs such as ergot derivatives. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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