Product image of Mepivacaine B. Braun (Mepivacaine Hydrochloride) supplied by GNH India

Mepivacaine B. Braun

Active Ingredient:
Mepivacaine Hydrochloride
Origin:
EU

Mepivacaine B. Braun (Mepivacaine Hydrochloride)

Mepivacaine, the active ingredient in Mepivacaine B. Braun, is a local anesthetic presented as a sterile solution for epidural, intramuscular and perineural use. It provides rapid onset nerve block for surgical and diagnostic procedures in adult patients.
GNH India supplies Mepivacaine B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Mepivacaine is a local anesthetic used in procedures that require temporary loss of sensation.

  • Local anesthesia: produces rapid, short‑duration numbness for minor surgical or dental procedures.
  • Epidural analgesia: enables pain control during labor, obstetric surgery, or postoperative recovery.
  • Peripheral nerve block: facilitates anesthesia of a specific limb or region for orthopedic or vascular surgery.
  • Intramuscular injection: provides localized anesthesia for muscle biopsies or minor interventions.
  • Dental procedures: allows painless tooth extractions and restorative work.

How It Works

  • Mepivacaine reversibly inhibits voltage‑gated sodium channels on neuronal membranes, stabilizing the inactive state of the channel. This blockade prevents the initiation and propagation of nerve impulses, resulting in a temporary loss of sensation in the targeted area without affecting surrounding tissues.

Side Effects

Mepivacaine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness
  • Nausea
  • Tingling or numbness around the injection site
  • Metallic taste in the mouth
  • Transient hypotension
  • Injection site pain

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction
  • Cardiac arrhythmias, including ventricular tachycardia
  • Central nervous system toxicity such as seizures
  • Methemoglobinemia (rare)

Precautions & Warnings

When using Mepivacaine, clinicians should observe several safety measures.

  • Allergy assessment: verify no known hypersensitivity to amide‑type local anesthetics.
  • Cardiovascular monitoring: observe for arrhythmias in patients with heart disease.
  • Dosage caution: avoid excessive volumes that may increase systemic toxicity.
  • Pregnancy consideration: use only if the anticipated benefit justifies potential risk.
  • Elderly patients: consider dose reduction due to decreased metabolic clearance.
  • Store at below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Mepivacaine can interact with other medications, requiring careful management.

Major Interactions (Avoid)

  • Class I antiarrhythmic agents (e.g., quinidine, procainamide): may potentiate cardiotoxicity.
  • Beta‑blockers: increase risk of bradycardia and hypotension.
  • MAO inhibitors: may enhance central nervous system toxicity.

Moderate Interactions (Monitor Closely)

  • Other local anesthetics: cumulative toxicity risk.
  • CNS depressants (e.g., benzodiazepines, opioids): may augment sedation and respiratory depression.
  • Diuretics: may alter plasma protein binding and affect drug levels.

Frequently Asked Questions

Mepivacaine B. Braun is a sterile injectable solution of the local anesthetic mepivacaine hydrochloride. It is employed to produce rapid, short‑duration numbness for epidural analgesia, intramuscular anesthesia, peripheral nerve blocks, and dental or minor surgical procedures where temporary loss of sensation is required.

Mepivacaine works by reversibly blocking voltage‑gated sodium channels on nerve membranes. This inhibition prevents the initiation and conduction of action potentials, thereby stopping the transmission of pain signals from the site of injection to the central nervous system.

The specific dose of Mepivacaine B. Braun is determined by the prescribing clinician based on the type of procedure, patient weight, age, and clinical condition. Only a qualified health professional should calculate and administer the appropriate volume.

Mepivacaine is classified as pregnancy category unknown. It should be used during pregnancy or lactation only when the potential therapeutic benefit justifies any possible risk to the fetus or infant, and after a careful risk‑benefit assessment by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Mepivacaine is often compared with lidocaine, another amide‑type local anesthetic. Both have rapid onset, but mepivacaine typically provides a slightly longer duration of action and is less vasodilatory, which can reduce the need for a vasoconstrictor in certain procedures.

Store the solution at or below 25 °C in its original packaging, protecting it from direct sunlight, moisture and extreme temperatures. Do not freeze the product. Inspect the vial for particulate matter or discoloration before use.

Mepivacaine B. Braun is administered by a qualified health professional via epidural, intramuscular or perineural injection. The injection technique follows standard aseptic procedures, and the dose is adjusted to the specific clinical situation and patient characteristics.

Serious risks include severe allergic reactions (anaphylaxis), cardiac toxicity such as arrhythmias or cardiac arrest, and central nervous system toxicity that can manifest as seizures or loss of consciousness. Immediate medical intervention is required if any of these events occur.

Patients with a known hypersensitivity to mepivacaine or other amide‑type local anesthetics should avoid its use. It is also contraindicated in individuals with severe cardiac conduction disorders, uncontrolled epilepsy, or those who have experienced previous severe systemic toxicity from local anesthetics.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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