Product image of Mepivacaïne Hcl B. Braun (Mepivacaine Hydrochloride) supplied by GNH India

Mepivacaïne Hcl B. Braun

Active Ingredient:
Mepivacaine Hydrochloride
Origin:
EU

Mepivacaïne Hcl B. Braun (Mepivacaine Hydrochloride)

Mepivacaine Hydrochloride, the active ingredient in Mepivacaïne Hcl B. Braun, is a local anesthetic presented as a sterile solution for epidural and perineural use. It provides reversible nerve blockade for surgical and diagnostic procedures.
GNH India supplies Mepivacaïne Hcl B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Mepivacaïne Hcl B. Braun is a local anesthetic used in regional anesthesia techniques.

  • Epidural anesthesia: provides analgesia for labor or surgical procedures via epidural injection.
  • Peripheral nerve block: creates targeted numbness for limb surgeries or diagnostic blocks.
  • Regional anesthesia: facilitates surgical anesthesia for procedures requiring nerve block without general anesthesia.

How It Works

  • Mepivacaine Hydrochloride acts by reversibly binding to voltage‑gated sodium channels on neuronal membranes, stabilizing the inactive state of the channel. This blocks the influx of sodium ions, preventing the initiation and propagation of nerve impulses, resulting in loss of sensation in the targeted area.

Side Effects

Mepivacaïne Hcl B. Braun may cause a range of adverse reactions.

Common Side Effects

  • Transient numbness or tingling at the injection site
  • Mild hypotension or dizziness
  • Nausea or metallic taste
  • Headache
  • Local swelling or erythema

Serious or Rare Side Effects

  • Allergic reaction including rash, bronchospasm, or anaphylaxis
  • Cardiovascular collapse or severe arrhythmia
  • Seizures or central nervous system toxicity
  • Prolonged numbness or motor block
  • Methemoglobinemia (rare)

Precautions & Warnings

When using Mepivacaïne Hcl B. Braun, several safety measures should be observed.

  • Assess patient allergy: verify no known hypersensitivity to amide‑type local anesthetics.
  • Monitor cardiovascular status: observe blood pressure and heart rate during administration.
  • Use lowest effective concentration: limit systemic toxicity risk.
  • Avoid intravascular injection: aspirate before injecting.
  • Pregnancy considerations: use only if potential benefit justifies potential risk.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Mepivacaïne Hcl B. Braun can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Class I antiarrhythmic agents (e.g., quinidine, procainamide): may increase cardiotoxicity.
  • Beta‑adrenergic blockers: can potentiate bradycardia.

Moderate Interactions (Monitor Closely)

  • Nonsteroidal anti‑inflammatory drugs: may increase bleeding risk.
  • General anesthetics (e.g., propofol): additive central nervous system depression.
  • Monoamine oxidase inhibitors: may affect drug metabolism and increase toxicity.

Frequently Asked Questions

Mepivacaïne Hcl B. Braun is a sterile solution of the local anesthetic mepivacaine hydrochloride. It is employed to produce regional anesthesia, most commonly for epidural analgesia during labor or surgery and for peripheral nerve blocks that numb specific limbs or areas during operative procedures.

Mepivacaine blocks voltage‑gated sodium channels on nerve membranes, stabilising them in an inactive state. By preventing sodium influx, the drug stops the generation and propagation of action potentials, resulting in a reversible loss of sensation in the area where it is administered.

The dose of Mepivacaïne Hcl B. Braun is determined by the prescribing clinician based on the type of procedure, patient weight, age, and clinical condition. Only a qualified health professional should calculate and administer the appropriate amount.

Safety data for mepivacaine during pregnancy and lactation are limited. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mepivacaine is an amide‑type local anesthetic with a rapid onset and intermediate duration, similar to lidocaine but with slightly longer sensory block and less vasodilatory effect. This can reduce the need for added vasoconstrictors in some procedures, offering a useful alternative when a longer block is desired.

The product should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect it from direct sunlight, moisture and extreme temperatures. Do not freeze the solution, and handle it with aseptic technique to maintain sterility.

Mepivacaïne Hcl B. Braun is administered by a qualified health professional via injection into the epidural space or around a peripheral nerve. The injection is performed under sterile conditions, often using a needle or catheter, and the volume injected is tailored to the specific clinical need.

Serious adverse events include allergic reactions such as anaphylaxis, cardiovascular collapse or severe arrhythmias, central nervous system toxicity leading to seizures, prolonged motor block, and rare cases of methemoglobinemia. Immediate medical attention is required if any of these symptoms occur.

Patients with a known hypersensitivity to mepivacaine, other amide‑type local anesthetics, or any component of the formulation should not receive the drug. It is also contraindicated in individuals with severe cardiac conduction disorders or uncontrolled epilepsy, unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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