Product image of Mercaptopurin Silver Pharma (Mercaptopurine Monohydrate) supplied by GNH India

Mercaptopurin Silver Pharma

Active Ingredient:
Mercaptopurine Monohydrate
Origin:
EU

Mercaptopurin Silver Pharma (Mercaptopurine Monohydrate)

Mercaptopurine Monohydrate, the active ingredient in Mercaptopurin Silver Pharma, is a purine antimetabolite presented as an oral tablet for oral use. It is employed in the treatment of acute lymphoblastic leukemia and as an immunosuppressant in inflammatory bowel disease, helping to control abnormal cell proliferation and immune response.

GNH India supplies Mercaptopurin Silver Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Silver Pharma S.L.

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Indications & Clinical Uses

Mercaptopurine is used in conditions that involve abnormal lymphoid proliferation or immune‑mediated inflammation.

  • Acute lymphoblastic leukemia (maintenance): prolongs remission by suppressing leukemic cell growth.
  • Acute lymphoblastic leukemia (induction): contributes to achieving complete remission as part of combination chemotherapy.
  • Inflammatory bowel disease (Crohn's disease, ulcerative colitis): reduces intestinal inflammation through immunosuppression.

How It Works

  • Mercaptopurine is intracellularly converted to thioinosine monophosphate, which inhibits de novo purine synthesis and becomes incorporated into DNA and RNA. This disrupts nucleic acid synthesis, leading to cytotoxicity in rapidly dividing cells, particularly lymphocytes, and thereby suppresses abnormal proliferation and immune activation.

Side Effects

Mercaptopurine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Vomiting: occasional episodes after dosing.
  • Loss of appetite: reduced food intake.
  • Fatigue: general tiredness.
  • Leukopenia: decreased white blood cell count.
  • Elevated liver enzymes: mild hepatic irritation.

Serious or Rare Side Effects

  • Severe bone marrow suppression: pancytopenia requiring medical intervention.
  • Pancreatitis: acute inflammation of the pancreas.
  • Hepatotoxicity: significant liver injury.
  • Opportunistic infections: due to immunosuppression.
  • Hypersensitivity reactions: rash, fever, or anaphylaxis.
  • Secondary malignancies: rare long‑term risk of other cancers.

Precautions & Warnings

Before initiating therapy, several safety considerations are recommended.

  • Blood monitoring: regular CBC to detect leukopenia or anemia.
  • Liver function tests: assess hepatic enzymes periodically.
  • Renal function: evaluate creatinine clearance for dose adjustment.
  • Pregnancy and lactation: avoid use unless benefits outweigh risks.
  • TPMT deficiency: test for enzyme activity to prevent toxicity.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mercaptopurine interacts with several medicines that can alter its efficacy or toxicity.

Major Interactions (Avoid)

  • Allopurinol: markedly increases mercaptopurine toxicity.
  • Azathioprine: additive myelosuppression.
  • Warfarin: may enhance anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Methotrexate: combined effect on bone marrow.
  • Trimethoprim‑sulfamethoxazole: may increase risk of myelosuppression.
  • Ribavirin: potential for enhanced hematologic toxicity.

Frequently Asked Questions

Mercaptopurin Silver Pharma contains mercaptopurine monohydrate and is indicated for the treatment of acute lymphoblastic leukemia, both in induction and maintenance phases, as well as for managing inflammatory bowel disease such as Crohn’s disease and ulcerative colitis by suppressing abnormal immune activity.

Mercaptopurine is converted inside cells to active metabolites that inhibit purine synthesis and become incorporated into DNA and RNA. This blocks the replication of rapidly dividing cells, particularly malignant lymphoblasts and overactive immune cells, thereby reducing disease activity.

The specific dose of Mercaptopurin Silver Pharma is individualized by the prescribing clinician based on the patient’s age, weight, disease severity, and laboratory parameters. Only a qualified healthcare professional should determine the appropriate dosing regimen.

Mercaptopurine is classified as a teratogenic agent and is generally contraindicated during pregnancy unless the potential benefit justifies the risk. It is also excreted in breast milk, so breastfeeding is not recommended while receiving this medication.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Both mercaptopurine and azathioprine are thiopurine immunosuppressants, but mercaptopurine is the active metabolite of azathioprine. Mercaptopurine offers more predictable pharmacokinetics, while azathioprine requires conversion in the body, potentially leading to variable exposure.

Store Mercaptopurin Silver Pharma at below 25 °C in its original packaging, protecting it from moisture and direct sunlight. Do not refrigerate unless specifically instructed by the manufacturer.

The product is supplied as oral tablets and should be taken by mouth with water, usually once daily or as directed by the prescriber. It may be taken with or without food, but consistency with meals helps reduce gastrointestinal upset.

The most serious risks include severe bone‑marrow suppression leading to pancytopenia, life‑threatening infections, hepatotoxicity, pancreatitis, and rare secondary malignancies. Patients should be monitored closely for blood count changes and liver function abnormalities.

Mercaptopurin should be avoided in patients with known hypersensitivity to mercaptopurine, severe liver disease, active infections, or documented deficiency of thiopurine methyltransferase (TPMT) without dose adjustment. It is also contraindicated during pregnancy and lactation unless absolutely necessary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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