Product image of Mercaptopurine Silver (Mercaptopurine Monohydrate) supplied by GNH India

Mercaptopurine Silver

Active Ingredient:
Mercaptopurine Monohydrate
Origin:
EU

Mercaptopurine Silver (Mercaptopurine Monohydrate)

Mercaptopurine, the active ingredient in Mercaptopurine Silver, is a purine analog antimetabolite presented as an oral formulation for oral use. It is employed in the treatment of certain leukemias and inflammatory bowel diseases, targeting rapidly dividing cells and modulating immune response.

GNH India supplies Mercaptopurine Silver as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Silver Pharma S.L.

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Indications & Clinical Uses

Mercaptopurine is used in conditions where inhibition of purine synthesis is therapeutic, particularly in hematologic malignancies and inflammatory bowel disorders.

  • Acute lymphoblastic leukemia: helps achieve remission by suppressing malignant lymphoblast proliferation.
  • Crohn's disease: reduces intestinal inflammation and maintains clinical remission.
  • Ulcerative colitis: controls mucosal inflammation and promotes disease remission.

How It Works

  • Mercaptopurine is converted intracellularly to thio‑inosine monophosphate, which interferes with de novo purine synthesis and becomes incorporated into DNA and RNA. This incorporation disrupts nucleic acid function, leading to cytotoxicity in rapidly dividing cells and immunosuppression through inhibition of lymphocyte proliferation.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Vomiting: occasional episodes after dosing.
  • Diarrhea: loose stools that may affect hydration.
  • Rash: skin redness or itching.
  • Headache: transient cranial discomfort.
  • Mild elevation of liver enzymes: detectable on routine labs.

Serious or Rare Side Effects

  • Severe bone marrow suppression: profound leukopenia or pancytopenia.
  • Hepatotoxicity: significant liver injury with jaundice.
  • Pancreatitis: acute inflammation of the pancreas.
  • Life‑threatening infections: opportunistic infections due to immunosuppression.
  • Hypersensitivity reactions: including Stevens‑Johnson syndrome.
  • Secondary malignancies: rare development of other cancers.

Precautions & Warnings

Careful monitoring and patient education are essential when using mercaptopurine.

  • Blood count monitoring: perform regular CBC to detect myelosuppression.
  • Liver function testing: assess transaminases before and during therapy.
  • Renal function assessment: adjust use in patients with impaired clearance.
  • Pregnancy considerations: avoid unless benefits outweigh potential fetal risks.
  • Concomitant drug review: evaluate for interactions that may increase toxicity.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct light.

Avoid Interactions

Mercaptopurine may interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Allopurinol: increases mercaptopurine toxicity; dose reduction required.
  • Azathioprine: additive myelosuppression risk.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Xanthine oxidase inhibitors: elevate plasma levels, heightening adverse effects.
  • TPMT deficiency (genetic): leads to severe bone marrow suppression.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may worsen renal impairment.
  • Sulfonamides: potential additive bone marrow suppression.
  • Oral contraceptives: possible reduction in hormonal efficacy.
  • Methotrexate: combined immunosuppression may increase infection risk.
  • Ribavirin: may enhance hematologic toxicity.

Frequently Asked Questions

Mercaptopurine Silver is indicated for the treatment of acute lymphoblastic leukemia, Crohn's disease, and ulcerative colitis. In these conditions it helps suppress abnormal cell growth or modulate immune activity to achieve disease control.

After oral absorption, mercaptopurine is metabolized to active thioguanine nucleotides that inhibit de novo purine synthesis and become incorporated into DNA and RNA. This disrupts nucleic acid function, leading to cytotoxicity in rapidly dividing cells and immunosuppression.

The specific dose of Mercaptopurine Silver is determined by the prescribing clinician based on the patient’s diagnosis, weight, renal and hepatic function, and other individual factors. Dosing regimens are not standardized and must follow a qualified health‑care professional’s order.

Safety data are limited; mercaptopurine may cause fetal harm and is generally avoided during pregnancy unless the therapeutic benefit justifies the risk. Breastfeeding is not recommended because the drug can be excreted in milk and affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mercaptopurine belongs to the purine analog class and differs from drugs such as azathioprine, which is a pro‑drug that converts to mercaptopurine in the body. Compared with biologic agents, mercaptopurine is a small‑molecule oral therapy, offering a different safety and monitoring profile.

Mercaptopurine Silver should be stored at ambient temperature, below 25 °C, in its original packaging. The container should be kept away from moisture, heat sources and direct sunlight to maintain product stability.

The medication is taken orally, usually with or without food as directed by the prescriber. Swallow tablets whole with a full glass of water; do not crush or split unless specifically instructed.

The most serious risks include severe bone marrow suppression leading to pancytopenia, hepatotoxicity, pancreatitis, life‑threatening infections, and rare hypersensitivity reactions such as Stevens‑Johnson syndrome. Patients should be monitored closely for these events.

Mercaptopurine Silver is contraindicated in individuals with known hypersensitivity to mercaptopurine or related compounds, in patients with severe hepatic or renal impairment, and in those with TPMT deficiency unless dose is appropriately reduced and closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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