Product image of Mercilon 28 (Desogestrel, Ethinylestradiol | Lactose Monohydrate) supplied by GNH India

Mercilon 28

Active Ingredient:
Desogestrel, Ethinylestradiol | Lactose Monohydrate
Origin:
EU

Mercilon 28 (Desogestrel, Ethinylestradiol | Lactose Monohydrate)

Desogestrel/Ethinylestradiol, the active ingredients in Mercilon 28, are a combined oral contraceptive presented as a tablet for oral use. They prevent pregnancy in women of reproductive age.

GNH India supplies Mercilon 28 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

N.V. Organon

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Indications & Clinical Uses

Mercilon 28, a combined oral contraceptive, is indicated for hormonal regulation to prevent pregnancy.

  • Prevention of pregnancy: provides reliable contraception for women of childbearing potential.
  • Menstrual cycle regulation: helps achieve more predictable bleeding and reduces dysmenorrhea.
  • Management of acne associated with androgen excess: may improve skin condition in women.

How It Works

  • Desogestrel/Ethinylestradiol suppresses the hypothalamic‑pituitary‑ovarian axis, inhibiting the mid‑cycle surge of luteinising hormone and preventing ovulation. The estrogen component stabilises the endometrial lining, while both agents thicken cervical mucus, creating a hostile environment for sperm penetration and reducing the likelihood of implantation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: swelling or discomfort.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or emotional lability.
  • Spotting between periods: irregular light bleeding.

Serious or Rare Side Effects

  • Venous thromboembolism: deep‑vein clot formation.
  • Pulmonary embolism: clot migration to lungs.
  • Stroke: cerebrovascular accident, especially in high‑risk patients.
  • Myocardial infarction: heart attack risk in susceptible individuals.
  • Severe allergic reaction: anaphylaxis with rash, swelling, or breathing difficulty.
  • Hepatic adenoma: benign liver tumor, rarely reported.

Precautions & Warnings

Before prescribing Mercilon 28, clinicians should consider several safety factors.

  • Contraindications: Do not use in women with known thromboembolic disorders.
  • Smoking: Avoid in patients over 35 years who smoke.
  • Cardiovascular risk: Assess hypertension, diabetes, or hyperlipidaemia before initiation.
  • Medication adherence: Take the tablet at the same time each day to maintain efficacy.
  • Pregnancy testing: Confirm non‑pregnant status before starting therapy.
  • Store at ambient temperature: keep below 25 °C in the original pack, protect from moisture.

Avoid Interactions

Mercilon 28 may interact with other medicines, altering contraceptive effectiveness.

Major Interactions (Avoid)

  • Antiepileptic enzyme inducers (e.g., carbamazepine, phenytoin): reduce hormone levels.
  • Rifampin and other strong antibiotics: may decrease contraceptive efficacy.
  • Protease inhibitor antiretrovirals (e.g., ritonavir): can increase hormone concentrations.

Moderate Interactions (Monitor Closely)

  • St. John’s wort: may lower effectiveness.
  • Azole antifungals (e.g., ketoconazole): may raise hormone levels.
  • Selective serotonin reuptake inhibitors: may increase risk of mood changes.

Frequently Asked Questions

Mercilon 28 is a combined oral contraceptive indicated primarily for the prevention of pregnancy in women of reproductive age. It is also prescribed to help regulate menstrual cycles and may be used to manage certain androgen‑related skin conditions such as acne.

The two hormones work together to suppress the hypothalamic‑pituitary‑ovarian axis, preventing the luteinising hormone surge that triggers ovulation. Ethinylestradiol stabilises the endometrium, while both agents thicken cervical mucus, creating a barrier that hinders sperm penetration and implantation.

The dosing regimen for Mercilon 28 is determined by the prescribing clinician. Typically, the product is taken once daily for 21 consecutive days followed by a 7‑day hormone‑free interval, but the exact schedule and any adjustments are set by the healthcare provider.

Mercilon 28 is contraindicated during pregnancy because its purpose is to prevent conception. Women who become pregnant should discontinue use immediately. Limited data are available for breastfeeding; clinicians usually advise caution and may recommend alternative contraception if lactation is ongoing.

To place an order, submit an enquiry on the Mercilon 28 product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mercilon 28 contains a specific dose of desogestrel and ethinylestradiol that offers a balance of efficacy and tolerability. Compared with older formulations that use levonorgestrel, desogestrel may be associated with a lower incidence of androgenic side effects such as acne, while maintaining comparable contraceptive protection.

Store Mercilon 28 at ambient temperature, preferably below 25 °C, in its original blister pack to protect from moisture and light. Keep the tablets out of reach of children and avoid storing them in bathrooms or other humid environments.

Mercilon 28 is taken orally, once each day, preferably at the same time each day. The tablet should be swallowed whole with water and not chewed. Adherence to the daily schedule is important to maintain contraceptive effectiveness.

Serious risks include venous thromboembolism, pulmonary embolism, stroke, myocardial infarction, and severe allergic reactions. Women should seek immediate medical attention if they experience unexplained leg pain, shortness of breath, chest pain, severe headache, or signs of an allergic reaction such as swelling or difficulty breathing.

Mercilon 28 is contraindicated for women with a history of thromboembolic disorders, uncontrolled hypertension, certain cardiovascular diseases, active liver disease, known or suspected breast cancer, or those who are pregnant. Smoking women over 35 years of age should also avoid this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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