Product image of Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone) supplied by GNH India

Meriofert

Active Ingredient:
Follicle-Stimulating Hormone, Luteinising Hormone
Origin:
EU

Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone)

Follicle‑stimulating hormone; Luteinising hormone, the active ingredient in Meriofert, is a gonadotropin presented as a sterile injectable solution for intramuscular or subcutaneous use. It is used to stimulate follicular development and ovulation in women with anovulatory infertility and to support controlled ovarian stimulation in assisted reproductive technologies.

GNH India supplies Meriofert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and reproductive health centres worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

  • Meriofert is a gonadotropin used in reproductive medicine to promote follicular growth and ovulation.
  • Infertility due to anovulation: supports follicular development and ovulation to improve chances of conception.
  • Controlled ovarian stimulation for assisted reproductive technology: enhances multiple follicle development for IVF or ICSI cycles.
  • Induction of ovulation in women undergoing intrauterine insemination: facilitates timed ovulation to increase success of IUI procedures.

How It Works

  • Follicle‑stimulating hormone and luteinising hormone in Meriofert bind to their respective FSH and LH receptors on ovarian (or testicular) cells, activating intracellular signaling pathways that promote follicular maturation, steroid hormone production, and the final ovulatory surge, thereby enabling successful gamete release and preparation of the reproductive tract for conception.

Side Effects

Common Side Effects

  • Injection site pain or bruising.
  • Mild abdominal discomfort or bloating.
  • Nausea or mild headache.
  • Transient hot flashes.
  • Mild ovarian hyperstimulation (elevated estradiol without severe symptoms).
  • Mild fatigue.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (severe) with rapid weight gain, ascites, or respiratory distress.
  • Multiple pregnancy (twins or higher order).
  • Allergic reactions including rash, urticaria, or anaphylaxis.
  • Thromboembolic events.
  • Ectopic pregnancy.
  • Severe abdominal pain indicating ovarian torsion.

Precautions & Warnings

  • Precautions should be observed when prescribing Meriofert to ensure patient safety and optimal outcomes.
  • Pregnancy: avoid use during established pregnancy unless specifically indicated.
  • Breastfeeding: limited data; assess risk‑benefit before administration.
  • Ovarian monitoring: perform ultrasound to detect excessive response.
  • Allergy: confirm no hypersensitivity to any excipients.
  • Concomitant estrogen therapy: may mask response; evaluate necessity.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Meriofert may interact with other hormonal agents and medications affecting coagulation.

Major Interactions (Avoid)

  • GnRH agonists: increase risk of severe ovarian hyperstimulation.
  • Clomiphene citrate: additive ovulation stimulation may lead to multiple follicles.
  • High‑dose estrogen therapy: can reduce efficacy of gonadotropin action.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: monitor for bleeding if injection site bruising occurs.
  • Thyroid hormones: adjust dosing if thyroid status changes.
  • Corticosteroids: may alter hormone metabolism; observe clinical response.

Frequently Asked Questions

Meriofert is a gonadotropin preparation containing follicle‑stimulating hormone and luteinising hormone. It is used to treat infertility caused by anovulation, to support controlled ovarian stimulation in assisted reproductive technology cycles, and to induce ovulation in women undergoing intrauterine insemination.

The follicle‑stimulating hormone and luteinising hormone components bind to specific receptors on ovarian cells, triggering signaling pathways that promote follicular growth, estrogen production, and the final ovulatory surge. This coordinated action enables the development of mature oocytes and prepares the reproductive tract for possible conception.

The dose of Meriofert is individualized. A qualified prescriber determines the amount, frequency, and duration based on the patient’s clinical condition, response to treatment, and monitoring results. Dosing regimens are not standardized and must follow the prescribing information.

Meriofert is not intended for use during an established pregnancy and should only be used under strict medical supervision when pregnancy is desired. Limited safety data are available for breastfeeding; clinicians should weigh potential risks and benefits before prescribing to nursing mothers.

To order Meriofert, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and necessary import documentation.

Meriofert combines both FSH and LH activity in a single injectable, whereas some alternatives provide only FSH (e.g., recombinant FSH) or require separate LH supplementation. This dual action can simplify protocols for certain patients, but the choice depends on individual response, treatment goals, and physician preference.

Meriofert must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. If the product reaches room temperature for a short period, it may be used, but it should be returned to the refrigerator promptly.

Meriofert is supplied as a sterile injectable solution for intramuscular or subcutaneous injection. Administration is performed by a qualified healthcare professional using aseptic technique, typically in a clinical setting, following the dosing schedule prescribed by the treating physician.

The most serious risks include severe ovarian hyperstimulation syndrome, which can cause rapid weight gain, abdominal pain, and respiratory compromise, as well as the possibility of multiple pregnancy and rare allergic reactions such as anaphylaxis. Patients should be closely monitored for these complications.

Meriofert is contraindicated in individuals with known hypersensitivity to any component of the formulation, in patients with active ovarian cysts, uncontrolled thyroid disease, or severe uncontrolled endocrine disorders. It should also be avoided in women who are already pregnant unless specifically indicated by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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