Product image of Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone) supplied by GNH India

Meriofert

Active Ingredient:
Follicle-Stimulating Hormone, Luteinising Hormone
Origin:
EU

Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone)

Follicle-Stimulating Hormone; Luteinising Hormone, the active ingredient in Meriofert, is a gonadotropin presented as a sterile injectable solution for intramuscular or subcutaneous use. It is employed to stimulate ovarian follicular development and ovulation in women with infertility disorders.

GNH India supplies Meriofert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Meriofert is a gonadotropin used in reproductive medicine to address disorders of ovarian function.

  • Infertility due to anovulation: promotes follicular growth and restores ovulation.
  • Assisted reproductive technology (ART): enhances follicular response for controlled ovarian stimulation in IVF cycles.
  • Hypogonadotropic hypogonadism: replaces deficient endogenous FSH and LH to initiate normal ovarian activity.

How It Works

  • Meriofert contains recombinant Follicle‑Stimulating Hormone and Luteinising Hormone that bind to their respective receptors on ovarian granulosa and theca cells. Activation of FSH receptors stimulates follicular maturation and estrogen synthesis, while LH receptor activation supports luteinisation and ovulation, together facilitating the development of a mature oocyte for conception.

Side Effects

Adverse reactions may occur with any injectable gonadotropin therapy.

Common Side Effects

  • Injection site pain or erythema: mild discomfort at the administration site.
  • Abdominal discomfort: transient bloating or cramping.
  • Headache: mild to moderate intensity.
  • Nausea: occasional upset stomach.
  • Mild ovarian hyperstimulation syndrome: mild abdominal distension and weight gain.
  • Pelvic pain: short‑lasting discomfort.

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome: rapid weight gain, severe abdominal pain, and fluid accumulation.
  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Anaphylactic reaction: hives, swelling, or difficulty breathing.
  • Pulmonary edema: shortness of breath with fluid in lungs.
  • Severe abdominal pain: may indicate ovarian torsion.
  • Vision changes: blurred vision or visual disturbances.

Precautions & Warnings

Before initiating Meriofert, clinicians should assess patient history and monitor response closely.

  • Assess baseline ovarian reserve: evaluate antral follicle count and hormone levels.
  • Monitor estradiol levels: adjust dose to avoid excessive stimulation.
  • Screen for contraindications: exclude patients with ovarian cysts or uncontrolled thyroid disease.
  • Counsel on signs of ovarian hyperstimulation: educate patients to report rapid weight gain or severe abdominal pain.
  • Review concomitant medications: avoid drugs that may exacerbate thrombotic risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Meriofert may interact with other agents that influence ovarian response or coagulation.

Major Interactions (Avoid)

  • GnRH agonists used concurrently: may cause excessive ovarian stimulation.
  • High‑dose estrogen therapy: can diminish gonadotropin effectiveness.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding with ovarian hyperstimulation.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may require a washout period before starting therapy.
  • Thyroid hormone replacement: monitor thyroid function as altered hormone levels affect response.
  • Antidiabetic agents: hyperstimulation can affect glucose control; monitor blood sugar.

Frequently Asked Questions

Meriofert is a gonadotropin preparation containing Follicle‑Stimulating Hormone and Luteinising Hormone. It is used to stimulate ovarian follicular development and ovulation in women with infertility caused by anovulation, to support controlled ovarian stimulation in assisted reproductive technology cycles, and to treat hypogonadotropic hypogonadism where endogenous gonadotropins are deficient.

The FSH component binds to FSH receptors on granulosa cells, promoting follicle growth and estrogen production. The LH component binds to LH receptors on theca and luteal cells, supporting androgen conversion to estrogen and triggering final oocyte maturation and ovulation. Together they mimic the natural hormonal cascade required for successful follicular development.

The dose of Meriofert is individualized by the prescribing physician based on the patient’s ovarian reserve, treatment protocol, and response to therapy. Clinicians determine the amount, frequency, and duration of administration, and adjustments are made according to monitoring of hormonal levels and ultrasound findings.

Meriofert is intended for use before conception to induce ovulation; it is not administered during pregnancy. Its safety in pregnancy has not been established, and it should be discontinued once pregnancy is confirmed. Limited data are available for breastfeeding, and the decision to use the product while nursing should be made by a qualified healthcare professional.

To order Meriofert, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including cold‑chain handling if needed) and any required import documentation.

Meriofert combines both FSH and LH in a single injectable formulation, whereas some alternatives provide only FSH or require separate LH supplementation. This dual‑action approach can simplify dosing schedules and may improve follicular response in certain patients, but the choice of therapy depends on individual clinical factors and physician preference.

Meriofert must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. If the product reaches room temperature, it should be used promptly and not be returned to refrigeration.

Meriofert is supplied as a sterile liquid for injection and is administered either intramuscularly or subcutaneously, as directed by the treating physician. The injection site is typically the abdomen or thigh, and aseptic technique must be followed to reduce the risk of infection.

The most serious risks include severe ovarian hyperstimulation syndrome, which can cause rapid weight gain, abdominal pain, and fluid accumulation; thromboembolic events such as deep‑vein thrombosis; and rare anaphylactic reactions. Patients should be monitored closely for these complications, and treatment should be discontinued if they occur.

Meriofert should not be used in patients with known hypersensitivity to any component of the formulation, active ovarian cysts, uncontrolled thyroid disease, or those who are pregnant. Caution is also advised for individuals with a history of thromboembolic disorders or severe cardiovascular disease, and the decision to treat should be made by a qualified specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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