Product image of Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone) supplied by GNH India

Meriofert

Active Ingredient:
Follicle-Stimulating Hormone, Luteinising Hormone
Origin:
EU

Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone)

Follicle-Stimulating Hormone and Luteinising Hormone, the active ingredient in Meriofert, is a gonadotropin presented as a sterile injectable solution for intramuscular and subcutaneous use. It treats infertility related to anovulation, hypogonadotropic hypogonadism, and supports assisted reproductive technology protocols in the European Union market.

GNH India supplies Meriofert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Pharma Kft

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Indications & Clinical Uses

Meriofert, a gonadotropin used in reproductive endocrinology, is indicated for:

  • Infertility due to anovulation: stimulates follicular growth to enable ovulation.
  • Hypogonadotropic hypogonadism: replaces deficient gonadotropins to restore normal gonadal function.
  • Assisted reproductive technology (ART) protocols: supports controlled ovarian stimulation in IVF cycles.
  • Ovarian stimulation in donor cycles: facilitates oocyte retrieval for donation programs.

How It Works

  • Meriofert contains recombinant Follicle‑Stimulating Hormone and Luteinising Hormone that act as agonists at FSH and LH receptors on ovarian granulosa and theca cells. Activation of these receptors promotes follicular development, estrogen synthesis, and the final ovulatory surge, thereby restoring normal reproductive hormone dynamics.

Side Effects

Adverse reactions reported with Meriofert may vary in frequency and severity.

Common Side Effects

  • Injection site pain or erythema: mild discomfort at the administration site.
  • Abdominal bloating: transient sensation of fullness.
  • Mild ovarian hyperstimulation: increased follicle size without severe symptoms.
  • Headache: occasional tension‑type headache.
  • Nausea: mild, self‑limiting gastrointestinal upset.
  • Fluid retention: mild peripheral edema.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (severe): rapid weight gain, abdominal pain, and respiratory distress.
  • Multiple pregnancy: increased risk of twins or higher order gestations.
  • Thromboembolic events: rare clot formation in veins.
  • Allergic reactions: rash, urticaria, or anaphylaxis.
  • Ectopic pregnancy: implantation outside the uterus.
  • Severe abdominal pain: may indicate ovarian torsion or rupture.

Precautions & Warnings

Before initiating Meriofert therapy, clinicians should consider several safety measures.

  • Baseline assessment: evaluate ovarian reserve and hormonal profile.
  • Monitoring: regularly measure estradiol levels and follicle size during treatment.
  • Cyst exclusion: avoid use in patients with active ovarian cysts.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Meriofert may interact with other medications that affect reproductive hormones or coagulation.

Major Interactions (Avoid)

  • Aromatase inhibitors: may blunt estrogen response to treatment.
  • GnRH antagonists: can reduce the efficacy of gonadotropin stimulation.
  • High‑dose estrogen therapy: increases risk of excessive ovarian stimulation.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may alter timing of ovarian stimulation cycles.
  • Anticoagulants: monitor for bleeding at injection sites.
  • Other gonadotropins: concurrent use may heighten hyperstimulation risk.

Frequently Asked Questions

Meriofert is a gonadotropin preparation that provides both Follicle‑Stimulating Hormone and Luteinising Hormone. It is used to treat infertility caused by anovulation, to replace deficient hormones in hypogonadotropic hypogonadism, and to support ovarian stimulation in assisted reproductive technology cycles such as in vitro fertilisation.

Both hormones act as agonists at their respective receptors on ovarian cells. Follicle‑Stimulating Hormone promotes growth and maturation of ovarian follicles, while Luteinising Hormone triggers the final maturation and ovulation of the dominant follicle. Together they restore the natural hormonal cascade required for successful ovulation and conception.

The dose of Meriofert is individualized by the prescribing clinician based on the patient’s ovarian reserve, treatment protocol, and response to therapy. The prescriber determines the amount, frequency, and duration of administration to achieve the desired ovarian response while minimizing the risk of overstimulation.

Meriofert is intended for use before conception to facilitate ovulation and is not administered during an established pregnancy. Safety data for use while breastfeeding are limited; therefore, it is generally avoided in lactating women unless the benefits outweigh potential risks as assessed by the treating physician.

To request Meriofert, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if required) and any necessary import documentation.

Meriofert combines both FSH and LH activity in a single injectable formulation, which can simplify dosing compared with regimens that require separate FSH‑only and LH‑only preparations. Clinical efficacy is comparable to other recombinant gonadotropins when used according to established ART protocols, while the safety profile reflects the class‑wide risk of ovarian hyperstimulation.

Meriofert must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the product. If refrigeration is temporarily unavailable, the product may be kept at controlled room temperature for a limited period as indicated in the manufacturer’s label.

Meriofert is supplied as a sterile injectable solution for intramuscular or subcutaneous injection. The healthcare professional prepares the dose according to the prescriber’s instructions, selects an appropriate injection site, and administers the medication using aseptic technique. Patients are monitored for response and any adverse reactions after each dose.

The most serious risks include severe ovarian hyperstimulation syndrome, which can cause rapid weight gain, abdominal pain, and respiratory compromise, as well as the possibility of multiple pregnancy and rare thromboembolic events. Prompt medical evaluation is required if patients experience significant abdominal distension, shortness of breath, or severe pain.

Meriofert should be avoided in individuals with known hypersensitivity to any component of the formulation, active ovarian cysts, uncontrolled thyroid disease, or severe uncontrolled systemic illness. It is also contraindicated in patients who are currently pregnant, as the medication is intended to induce ovulation prior to conception.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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