Product image of Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone) supplied by GNH India

Meriofert

Active Ingredient:
Follicle-Stimulating Hormone, Luteinising Hormone
Origin:
EU

Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone)

Follicle-Stimulating Hormone, Luteinising Hormone, the active ingredient in Meriofert, is a gonadotropin presented as an injectable solution for intramuscular or subcutaneous use. It is used to treat infertility caused by anovulation and to support controlled ovarian stimulation in assisted reproductive technologies for women of reproductive age.

GNH India supplies Meriofert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Meriofert is a gonadotropin that acts on the ovarian hormonal axis to facilitate follicular growth and ovulation.

  • Anovulatory infertility: induces follicular development and ovulation in women who do not ovulate spontaneously.
  • Assisted reproductive technology cycles: provides controlled ovarian stimulation to obtain multiple mature oocytes for IVF or ICSI.
  • Hypogonadotropic hypogonadism: supplies exogenous FSH and LH to stimulate ovarian function in patients with deficient endogenous gonadotropins.

How It Works

  • Meriofert contains recombinant Follicle‑Stimulating Hormone and Luteinising Hormone that bind to their respective FSH and LH receptors on ovarian granulosa and theca cells. Receptor activation triggers intracellular signaling cascades that increase estrogen synthesis, promote follicle maturation, and ultimately trigger ovulation, enabling the development of viable oocytes for conception.

Side Effects

Common Side Effects

  • Injection site pain or erythema.
  • Mild abdominal or pelvic discomfort.
  • Headache.
  • Nausea or mild gastrointestinal upset.
  • Transient ovarian cyst formation.
  • Mild ovarian hyperstimulation (limited to mild ovarian enlargement).

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome (OHSS) with ascites or thromboembolic complications.
  • Multiple pregnancy (twins or higher order).
  • Allergic reactions including anaphylaxis.
  • Ectopic pregnancy.
  • Thromboembolic events such as deep vein thrombosis.
  • Severe ovarian cyst rupture with intra‑abdominal bleeding.

Precautions & Warnings

Meriofert should be used under close medical supervision with individualized dosing.

  • Monitor ovarian response: perform ultrasound and estradiol monitoring to adjust dose.
  • Avoid in uncontrolled thyroid disease: thyroid status can affect gonadotropin response.
  • Caution in estrogen‑sensitive tumors: assess risk before initiating therapy.
  • Do not use during pregnancy: the drug is intended for pre‑conception ovarian stimulation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Major Interactions (Avoid)

  • Estrogen‑containing contraceptives: may blunt the intended ovarian response.
  • High‑dose glucocorticoids: can interfere with gonadotropin activity.
  • Anticoagulant therapy: increased risk of ovarian cyst rupture.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone replacement: may require dose adjustment of gonadotropins.
  • GnRH agonists/antagonists: timing must be coordinated to avoid overstimulation.
  • Dopamine agonists (e.g., bromocriptine): may affect prolactin‑mediated ovarian function.

Frequently Asked Questions

Meriofert is a gonadotropin preparation containing Follicle‑Stimulating Hormone and Luteinising Hormone. It is prescribed to induce ovulation in women with anovulatory infertility and to support controlled ovarian stimulation in assisted reproductive technology cycles such as in‑vitro fertilisation.

The FSH component binds to FSH receptors on ovarian granulosa cells, stimulating estrogen production and follicle growth. The LH component binds to LH receptors on theca cells, promoting androgen conversion to estrogen and triggering final follicular maturation and ovulation. Together they mimic the natural hormonal surge required for oocyte development.

The dose of Meriofert is individualized and set by the prescribing physician based on the patient’s ovarian response, body weight, and treatment protocol. The prescriber determines the amount, frequency, and duration of administration to achieve the desired ovarian stimulation while minimizing risk.

Meriofert is intended for use before conception to stimulate ovulation and is not recommended during pregnancy. Safety data for use while breastfeeding are limited; therefore, it should be avoided unless the benefits outweigh potential risks and a healthcare professional advises otherwise.

To order Meriofert, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and necessary import documentation.

Meriofert combines both FSH and LH in a single injectable formulation, offering a convenient alternative to using separate FSH‑only and LH‑only preparations. This dual‑action approach can simplify dosing schedules and may improve synchronization of follicular development compared with single‑component gonadotropins.

Meriofert must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. It should be kept in its original packaging until use to maintain stability and potency.

Meriofert is administered by a healthcare professional via intramuscular or subcutaneous injection, typically in the thigh or abdomen. The exact injection site, volume, and frequency are determined by the treating physician based on the individual treatment plan.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can lead to fluid accumulation, thrombosis, or organ dysfunction, and the possibility of multiple pregnancy. Prompt monitoring and dose adjustment are essential to mitigate these risks.

Meriofert is contraindicated in women who are currently pregnant, have uncontrolled thyroid disease, estrogen‑sensitive tumors, or a history of severe OHSS. It should also be avoided in patients with known hypersensitivity to any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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