Product image of Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone) supplied by GNH India

Meriofert

Active Ingredient:
Follicle-Stimulating Hormone, Luteinising Hormone
Origin:
EU

Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone)

Follicle‑Stimulating Hormone; Luteinising Hormone, the active ingredient in Meriofert, is a gonadotropin presented as an injectable solution for intramuscular or subcutaneous use. It is used to stimulate ovarian follicular development and ovulation in women with infertility due to anovulation.
GNH India supplies Meriofert as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Meriofert, a gonadotropin used in reproductive medicine, is indicated for the following conditions:

  • Infertility due to anovulation: promotes follicular growth and ovulation in women who do not ovulate spontaneously.
  • Controlled ovarian stimulation for assisted reproductive technologies: supports development of multiple follicles to obtain oocytes for IVF or ICSI.
  • Oocyte donation cycles: enables safe ovarian stimulation in egg donors to retrieve mature oocytes for donation programs.

How It Works

  • Meriofert contains both follicle‑stimulating hormone (FSH) and luteinising hormone (LH). The FSH component binds to FSH receptors on granulosa cells, stimulating estrogen production and follicular maturation, while the LH component activates LH receptors on theca cells, promoting androgen synthesis that is aromatized to estrogen. Together, they mimic the natural pituitary surge, driving follicle development and triggering ovulation.

Side Effects

Meriofert may cause a range of adverse reactions. Monitoring and patient counseling are essential.

Common Side Effects

  • Injection site pain or erythema: mild discomfort at the injection site.
  • Abdominal bloating or discomfort: transient gastrointestinal symptoms.
  • Nausea or mild vomiting: usually self‑limited.
  • Headache: may occur during early treatment.
  • Mild ovarian hyperstimulation: enlarged ovaries without severe symptoms.
  • Mood changes: occasional irritability or emotional lability.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (severe): rapid weight gain, ascites, respiratory distress.
  • Multiple pregnancy: increased risk of twins or higher‑order gestations.
  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Anaphylactic reaction: severe allergy requiring immediate medical attention.
  • Ectopic pregnancy: implantation outside the uterine cavity.
  • Severe abdominal pain: may indicate ovarian torsion or rupture.

Precautions & Warnings

Before initiating Meriofert therapy, several safety considerations should be observed.

  • Pregnancy testing: confirm non‑pregnant status prior to treatment.
  • Ovarian monitoring: perform serial ultrasound to assess follicular response.
  • Risk of OHSS: educate patients on signs of ovarian hyperstimulation syndrome and intervene promptly.
  • Multiple gestation counseling: discuss increased likelihood of twins or higher‑order pregnancies.
  • Hypersensitivity assessment: verify no known allergy to gonadotropin preparations.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Meriofert can interact with other medications that affect reproductive hormones or coagulation.

Major Interactions (Avoid)

  • GnRH antagonists: may diminish the efficacy of Meriofert.
  • Oral contraceptives: suppress endogenous gonadotropins, reducing response.
  • High‑dose estrogen therapy: can interfere with follicular stimulation.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone replacement: adjust dosing if thyroid status changes.
  • Anticoagulants: monitor for thrombosis risk if severe OHSS develops.
  • Corticosteroids: may alter ovarian response, requiring dose adjustment.

Frequently Asked Questions

Meriofert is a gonadotropin preparation indicated for women with infertility due to anovulation and for controlled ovarian stimulation in assisted reproductive technology cycles such as in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). It helps develop multiple mature follicles to increase the chance of successful egg retrieval.

The FSH component of Meriofert binds to receptors on granulosa cells, stimulating estrogen production and follicular growth. The LH component activates receptors on theca cells, promoting androgen synthesis that is converted to estrogen. Together they replicate the natural pituitary surge, driving follicular maturation and triggering ovulation.

The dose of Meriofert is individualized. A qualified prescriber determines the amount, frequency and duration based on the patient’s ovarian response, treatment protocol and clinical goals. Dosing regimens are adjusted during therapy according to ultrasound monitoring and hormone levels.

Meriofert is not intended for use during an established pregnancy and its safety in pregnancy has not been established. It is also not recommended for breastfeeding mothers because the effects on the infant are unknown. Treatment should be stopped if pregnancy occurs.

To order Meriofert, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Meriofert combines both FSH and LH activity in a single injectable, whereas some alternatives provide only recombinant FSH or urinary‑derived preparations. The combined formulation can simplify dosing schedules and may better mimic natural pituitary output, but clinical choice depends on individual patient response, cost considerations and physician preference.

Meriofert must be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. If the product reaches room temperature for a short period during administration, it may be used, but it should be returned to refrigeration promptly.

Meriofert is administered by a healthcare professional via intramuscular or subcutaneous injection. The injection site is typically the abdomen or thigh. Proper aseptic technique and accurate dosing are essential, and patients are usually monitored with serial ultrasounds and hormone assays throughout the stimulation cycle.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can cause rapid weight gain, abdominal pain, and respiratory distress; multiple pregnancy, which raises obstetric complications; thromboembolic events; and rare allergic reactions such as anaphylaxis. Prompt medical attention is required if any of these occur.

Meriofert is contraindicated in individuals with known hypersensitivity to gonadotropin preparations, active ovarian cysts, uncontrolled thyroid disease, severe ovarian failure, or in women who are already pregnant. Caution is also advised for patients with a history of thromboembolic disorders or severe cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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