Product image of Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone) supplied by GNH India

Meriofert

Active Ingredient:
Follicle-Stimulating Hormone, Luteinising Hormone
Origin:
EU

Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone)

Follicle-Stimulating Hormone, the active ingredient in Meriofert, is a gonadotropin presented as an injectable solution for intramuscular and subcutaneous use. It treats infertility‑related conditions in women, such as anovulation, and supports ovarian stimulation for assisted reproductive technologies.

GNH India supplies Meriofert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Meriofert, a gonadotropin used in reproductive endocrinology, is indicated for:

  • Induction of ovulation in women with anovulation or oligo‑ovulation: stimulates follicular development to achieve ovulation.
  • Controlled ovarian stimulation for assisted reproductive technologies (e.g., IVF): supports multiple follicle growth for egg retrieval.
  • Treatment of hypogonadotropic hypogonadism: replaces deficient gonadotropins to restore normal ovarian function.

How It Works

  • Meriofert contains follicle‑stimulating hormone (FSH) and luteinising hormone (LH). Both hormones bind to their respective G‑protein‑coupled receptors on ovarian granulosa and theca cells. FSH promotes follicular growth and estradiol synthesis, while LH triggers final maturation, ovulation and luteal phase support. The combined action mimics the natural pituitary gonadotropin surge required for successful folliculogenesis.

Side Effects

Adverse reactions to Meriofert may vary in frequency and severity.

Common Side Effects

  • Injection site pain: mild discomfort or erythema at the injection site.
  • Headache: transient headache of mild to moderate intensity.
  • Nausea: occasional nausea, often self‑limiting.
  • Ovarian hyperstimulation syndrome (mild): abdominal bloating and mild discomfort.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (severe): significant abdominal distension, ascites, thromboembolic events.
  • Thromboembolic complications: deep vein thrombosis or pulmonary embolism.
  • Allergic reaction: anaphylaxis, urticaria, or angioedema.

Precautions & Warnings

When prescribing Meriofert, clinicians should consider several safety and handling precautions.

  • Patient assessment: evaluate ovarian reserve and baseline hormone levels before initiation.
  • Monitoring: perform regular ultrasound and estradiol monitoring to detect ovarian hyperstimulation.
  • Contraindications: avoid use in pregnancy, active ovarian cysts, or uncontrolled thyroid disease.
  • Drug interactions: review concomitant use of estrogen‑containing products that may alter response.
  • Thrombotic risk: assess personal or family history of thromboembolic disease.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Meriofert may interact with other medicines that influence hormone levels or coagulation.

Major Interactions (Avoid)

  • Estrogen therapy: may increase risk of ovarian hyperstimulation.
  • Anticoagulants: heightened risk of bleeding when severe OHSS occurs.
  • GnRH agonists/antagonists: concurrent use requires dose adjustment to avoid excessive stimulation.

Moderate Interactions (Monitor Closely)

  • Thyroid hormones: altered metabolism may affect response to gonadotropins.
  • Corticosteroids: may mask early signs of OHSS.
  • Dopamine agonists: can interfere with prolactin regulation and ovarian response.

Frequently Asked Questions

Meriofert is a gonadotropin preparation that contains follicle‑stimulating hormone and luteinising hormone. It is used to induce ovulation in women with anovulation or oligo‑ovulation, to stimulate the ovaries during assisted reproductive techniques such as in‑vitro fertilisation, and to treat hypogonadotropic hypogonadism by replacing deficient pituitary hormones.

FSH binds to receptors on ovarian granulosa cells, promoting follicular growth and estradiol production. LH binds to receptors on theca and luteal cells, triggering final follicle maturation, ovulation and luteal phase support. Together they replicate the natural pituitary surge that drives normal folliculogenesis and ovulation.

The dose of Meriofert is individualized and determined by the prescribing physician based on the patient’s ovarian reserve, treatment protocol and response to monitoring. Dosing regimens can vary widely, and the prescriber will adjust the amount and frequency to achieve the desired clinical outcome.

Meriofert is not intended for use during an established pregnancy and is contraindicated in pregnant women. Safety data for breastfeeding are limited; therefore, the product should be used with caution, and the prescriber should weigh potential risks against benefits before administering to nursing mothers.

To order Meriofert, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including cold‑chain logistics if needed) and any required import documentation.

Meriofert combines both FSH and LH in a single injectable formulation, whereas some alternatives provide only FSH or require separate LH supplementation. The combined product can simplify dosing schedules and may improve follicular response in patients who need both hormones, but the choice depends on individual protocol preferences and physician experience.

Meriofert must be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. If temporary temperature excursions occur, discard the product according to local regulations.

Meriofert is supplied as a sterile injectable solution for intramuscular or subcutaneous injection. The injection is performed by a qualified healthcare professional using aseptic technique. The exact injection site, volume and frequency are prescribed by the treating clinician based on the therapeutic protocol.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can cause abdominal distension, ascites, thromboembolic events, and electrolyte imbalance, as well as rare allergic reactions such as anaphylaxis. Prompt recognition and medical management of these conditions are essential.

Meriofert should not be used in women who are already pregnant, have active ovarian cysts, uncontrolled thyroid disease, or a known hypersensitivity to any component of the formulation. Patients with a personal or strong family history of thromboembolic disorders should be evaluated carefully before treatment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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