Product image of Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone) supplied by GNH India

Meriofert

Active Ingredient:
Follicle-Stimulating Hormone, Luteinising Hormone
Origin:
EU

Meriofert (Follicle-Stimulating Hormone, Luteinising Hormone)

Follicle-Stimulating Hormone; Luteinising Hormone, the active ingredient in Meriofert, is a gonadotropin presented as an injectable solution for subcutaneous use. It is used to stimulate ovarian follicular development in women with infertility related to anovulation or hypogonadotropic hypogonadism.

GNH India supplies Meriofert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

  • Meriofert acts on the reproductive hormone axis to support follicular growth and ovulation in several infertility contexts.
  • Infertility due to anovulation: induces ovulation by stimulating follicle development.
  • Hypogonadotropic hypogonadism: replaces deficient gonadotropins to restore ovarian function.
  • Assisted reproductive technology (ART) protocols: provides controlled ovarian stimulation for egg retrieval.

How It Works

  • Meriofert contains recombinant follicle‑stimulating hormone (FSH) and luteinising hormone (LH) that bind to their respective receptors on ovarian granulosa and theca cells. Activation of these receptors triggers intracellular signaling cascades that promote follicular maturation, estradiol synthesis, and the LH surge required for ovulation, while also supporting luteal phase hormone production.

Side Effects

Meriofert may cause a range of adverse reactions, from mild to severe. Monitoring and prompt reporting are essential.

Common Side Effects

  • Injection site pain or erythema.
  • Mild abdominal discomfort or bloating.
  • Nausea or mild headache.
  • Transient mild ovarian hyperstimulation syndrome.
  • Mood changes or fatigue.

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome with rapid weight gain and fluid accumulation.
  • Allergic reactions including anaphylaxis.
  • Thromboembolic events such as deep vein thrombosis.
  • Multiple pregnancy resulting from excessive follicular response.
  • Ectopic pregnancy.

Precautions & Warnings

  • Prior to initiating Meriofert, clinicians should assess patient suitability and monitor response closely.
  • Monitor ovarian response: use serial ultrasound and estradiol measurements.
  • Assess contraindications: avoid in active ovarian cysts or uncontrolled thyroid disease.
  • Avoid use in pregnancy: the drug is not indicated for pregnant women.
  • Consider risk of multiple pregnancy: limit the number of developing follicles.
  • Adjust dose in renal or hepatic impairment: follow prescriber guidance.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Meriofert may interact with other medications that influence hormonal balance or coagulation.

Major Interactions (Avoid)

  • GnRH agonists: can amplify response and increase risk of severe ovarian hyperstimulation.
  • Estrogen‑containing contraceptives: may antagonize the intended ovulatory effect.
  • High‑dose corticosteroids: may alter hormone metabolism and reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: monitor for bleeding if ovarian cyst rupture occurs.
  • Thyroid hormone therapy: may affect overall hormonal response.
  • Concurrent use of other gonadotropins: avoid overlapping therapy to prevent excessive stimulation.

Frequently Asked Questions

Meriofert is a prescription injectable that contains both follicle‑stimulating hormone (FSH) and luteinising hormone (LH). It is used to stimulate ovarian follicle development and induce ovulation in women with infertility caused by anovulation, hypogonadotropic hypogonadism, or as part of assisted reproductive technology (ART) protocols.

The FSH component binds to FSH receptors on granulosa cells, promoting follicular growth and estradiol production. The LH component binds to LH receptors on theca and luteal cells, supporting the final maturation of the dominant follicle and triggering ovulation. Together they mimic the natural hormonal surge required for successful egg release.

The dose of Meriofert is individualized by the prescribing clinician based on the patient’s age, weight, underlying diagnosis, and response to prior stimulation. Dosage regimens are adjusted using serial ultrasound and hormone monitoring, and the prescriber sets the exact amount and schedule for each treatment cycle.

Meriofert is not intended for use in women who are already pregnant, and it should be discontinued once pregnancy is confirmed. Safety data for breastfeeding are limited, and the drug is generally avoided during lactation unless the benefits clearly outweigh potential risks, as determined by a qualified healthcare professional.

To place an order, submit an enquiry on the Meriofert product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed), and any required import documentation.

Meriofert combines both FSH and LH in a single formulation, which can simplify treatment protocols compared with using separate FSH‑only and LH‑only preparations. This dual‑action approach may reduce the number of injections and improve patient compliance, while delivering comparable efficacy to other recombinant gonadotropin products when used under specialist supervision.

Meriofert must be stored refrigerated at 2‑8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. If the product must be transported, use validated cold‑chain containers to maintain the required temperature range throughout delivery.

Meriofert is administered by subcutaneous injection, typically into the abdominal wall or thigh. The injection is performed using a sterile needle and syringe, following aseptic technique. The exact injection site, volume, and timing are determined by the treating physician based on the individual stimulation protocol.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can cause rapid weight gain, abdominal pain, and fluid accumulation; allergic reactions ranging from rash to anaphylaxis; thromboembolic events; and the possibility of multiple pregnancy. Patients should be monitored closely for early signs of these complications.

Meriofert is contraindicated in women with known hypersensitivity to any component of the product, active ovarian cysts, uncontrolled thyroid disease, or those who are already pregnant. It should also be used with caution in patients with severe renal or hepatic impairment, and it is not recommended for individuals with a history of thromboembolic disorders unless specifically advised by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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