Product image of Meriofert (Luteinising Hormone (Human), Follicle-Stimulating Hormone) supplied by GNH India

Meriofert

Active Ingredient:
Luteinising Hormone (Human), Follicle-Stimulating Hormone
Origin:
EU

Meriofert (Luteinising Hormone (Human), Follicle-Stimulating Hormone)

Human luteinising hormone and human follicle‑stimulating hormone, the active ingredients in Meriofert, are gonadotropins presented as a solution for injection for intramuscular or subcutaneous use. They are employed to stimulate ovarian follicular development and induce ovulation in women with infertility related to anovulation.\n\nGNH India supplies Meriofert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

  • Meriofert is a gonadotropin preparation that acts on the hypothalamic‑pituitary‑ovarian axis to support reproductive function.\n\nInfertility due to anovulation: supports follicular growth and induces ovulation in women who do not ovulate spontaneously.\nControlled ovarian stimulation: enhances follicle development for timed egg retrieval in assisted reproduction cycles.\nAssisted reproductive technology: provides the hormonal support required for in‑vitro fertilisation and related procedures.

How It Works

  • The luteinising hormone and follicle‑stimulating hormone components of Meriofert bind to LH and FSH receptors on ovarian granulosa and theca cells. This activation triggers intracellular signaling that promotes follicular maturation, estradiol synthesis, and the LH surge necessary for ovulation, thereby facilitating the reproductive cycle in women with impaired endogenous gonadotropin production.

Side Effects

  • Meriofert may cause a range of adverse reactions following injection.\n\nCommon Side Effects:\n- Injection site pain or erythema\n- Mild abdominal discomfort\n- Nausea or vomiting\n- Headache\n- Transient ovarian cyst formation\n\nSerious or Rare Side Effects:\n- Ovarian hyperstimulation syndrome (OHSS)\n- Multiple pregnancy\n- Severe allergic reaction (anaphylaxis)\n- Thromboembolic events\n- Significant ovarian torsion

Precautions & Warnings

  • When using Meriofert, clinicians should observe several safety measures.\n\nMonitor ovarian response: perform serial ultrasound and estradiol assessments.\nAvoid in active ovarian cysts: postpone treatment until resolution.\nUse with caution in thyroid disease: adjust therapy as needed.\nConsider risk of OHSS: limit dose escalation in high‑responders.\nStore at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Meriofert can interact with other medications that affect ovarian stimulation or hormonal balance.\n\nMajor Interactions (Avoid):\n- GnRH agonists: may amplify ovarian response, increasing OHSS risk.\n- Estrogen‑containing contraceptives: can blunt therapeutic effect.\n- Concurrent gonadotropins: additive stimulation may lead to excessive follicular development.\n\nModerate Interactions (Monitor Closely):\n- Thyroid hormone therapy: may require dose adjustment.\n- Corticosteroids: can influence hormone metabolism.\n- Anticoagulants: monitor for bleeding at injection sites.

Frequently Asked Questions

Meriofert is used to treat infertility caused by anovulation, to support controlled ovarian stimulation in assisted reproductive technology cycles, and to provide hormonal support during in‑vitro fertilisation procedures. It helps promote follicular development and ovulation in women who have insufficient endogenous gonadotropin activity.

Both hormones bind to specific receptors on ovarian cells. Follicle‑stimulating hormone stimulates granulosa cells to proliferate and produce estradiol, while luteinising hormone triggers the final maturation of the dominant follicle and the ovulatory surge. Together they coordinate the growth and release of a mature egg.

The dose of Meriofert is individualized by the prescribing clinician based on the patient’s ovarian response, treatment protocol, and underlying condition. Dosage regimens are determined after careful monitoring of hormonal levels and ultrasound findings, and may be adjusted throughout the treatment cycle.

Meriofert is intended for use before conception to induce ovulation; its safety in established pregnancy has not been established, and it is generally not recommended during pregnancy. Limited data are available for breastfeeding, so clinicians usually advise against use while nursing until further information is obtained.

To order Meriofert, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed) and any required import documentation.

Meriofert combines both LH and FSH activities in a single injectable solution, whereas some alternatives provide only FSH or require separate LH supplementation. This dual‑action formulation can simplify dosing schedules and may improve follicular synchrony, but the choice of product depends on individual patient response and the specific protocol used by the fertility clinic.

Meriofert must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. Before use, allow the vial to reach room temperature if required, and inspect for particulate matter or discoloration. Follow aseptic technique when preparing the injection.

Meriofert is supplied as a sterile solution for injection and is administered either intramuscularly or subcutaneously, as directed by the treating physician. The injection is typically given in the abdomen or thigh, using a sterile needle and syringe, and the site should be rotated to reduce local irritation.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can cause abdominal pain, rapid weight gain, and, in severe cases, fluid accumulation in the chest or abdomen. Multiple pregnancy and severe allergic reactions such as anaphylaxis are also rare but critical complications that require immediate medical attention.

Meriofert should be avoided in patients with active ovarian cysts, uncontrolled thyroid disease, known hypersensitivity to any component of the formulation, or those who have experienced severe OHSS in a previous cycle. It is also contraindicated in women who are currently pregnant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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