Product image of Meriofert (Luteinising Hormone (Human), Follicle-Stimulating Hormone) supplied by GNH India

Meriofert

Active Ingredient:
Luteinising Hormone (Human), Follicle-Stimulating Hormone
Origin:
EU

Meriofert (Luteinising Hormone (Human), Follicle-Stimulating Hormone)

Luteinising Hormone (Human) and Follicle‑Stimulating Hormone, the active ingredients in Meriofert, are gonadotropins presented as a sterile injectable solution for intramuscular or subcutaneous use. They are employed to stimulate ovarian follicle development and induce ovulation in women with infertility due to anovulation.

GNH India supplies Meriofert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Meriofert is a gonadotropin used in reproductive medicine to support ovarian stimulation and ovulation.

  • Infertility due to anovulation: induces follicular development and ovulation.
  • Assisted reproductive technology (ART): provides hormonal support during IVF and ICSI cycles.
  • Controlled ovarian hyperstimulation: enhances the number of mature oocytes retrieved for fertilisation.

How It Works

  • Meriofert contains human luteinising hormone (LH) and follicle‑stimulating hormone (FSH) which bind to LH and FSH receptors on ovarian granulosa and theca cells. Activation of these G‑protein‑coupled receptors stimulates intracellular cAMP production, promoting follicular growth, estrogen synthesis, and the final LH surge that triggers ovulation.

Side Effects

Adverse reactions may occur following administration of Meriofert.

Common Side Effects

  • Injection site pain or erythema.
  • Mild abdominal discomfort or bloating.
  • Headache.
  • Nausea.
  • Transient dizziness.
  • Mild ovarian hyperstimulation syndrome (OHSS).

Serious or Rare Side Effects

  • Severe OHSS with rapid weight gain and ascites.
  • Thromboembolic events.
  • Allergic reactions including rash, urticaria, or anaphylaxis.
  • Multiple pregnancy.
  • Ectopic pregnancy.
  • Severe abdominal pain or hemorrhage.

Precautions & Warnings

Prior assessment and monitoring are essential when using Meriofert.

  • Baseline ovarian assessment: evaluate follicular reserve before initiation.
  • Estradiol monitoring: check serum levels during stimulation.
  • Use lowest effective dose: minimise risk of OHSS.
  • Contraindication in known hypersensitivity: avoid if allergic to any component.
  • Pregnancy avoidance: do not use in confirmed pregnancy.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Meriofert may interact with other medications affecting ovarian response or coagulation.

Major Interactions (Avoid)

  • Concurrent high‑dose estrogen therapy: increases risk of severe OHSS.
  • Other gonadotropins administered simultaneously: may cause excessive ovarian stimulation.
  • GnRH agonists used for down‑regulation without proper timing: can blunt intended response.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: monitor for injection‑site bleeding.
  • Corticosteroids: may alter hormonal response, require dose adjustment.
  • Thyroid hormone replacement: assess thyroid status as it influences ovarian function.

Frequently Asked Questions

Meriofert is a prescription injectable that contains human luteinising hormone and follicle‑stimulating hormone. It is used to stimulate ovarian follicle growth and induce ovulation in women experiencing infertility due to anovulation, and it provides hormonal support during assisted reproductive technology procedures such as in‑vitro fertilisation.

The luteinising hormone (LH) and follicle‑stimulating hormone (FSH) in Meriofert bind to their respective receptors on ovarian cells. This activates intracellular signalling pathways that promote follicular maturation, estrogen production, and the final LH surge that triggers the release of a mature egg, facilitating conception.

The dose of Meriofert is individualized by the treating physician based on the patient’s ovarian reserve, response to prior stimulation, and the specific assisted reproductive protocol. Only a qualified healthcare professional should determine the appropriate dosing schedule.

Meriofert is intended for use before conception to induce ovulation and is not recommended for use during an established pregnancy. Safety data for breastfeeding are limited, and the medication should only be used if the benefits outweigh potential risks, as determined by a healthcare provider.

To request Meriofert, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if required) and necessary import documentation.

Meriofert combines both LH and FSH in a single injectable formulation, which can simplify treatment regimens compared with using separate LH and FSH preparations. This dual‑action approach may improve coordination of follicular development and ovulation, but the choice of product depends on individual patient characteristics and clinician preference.

Meriofert should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any product that appears discoloured or contains particles.

Meriofert is administered by a qualified healthcare professional via intramuscular or subcutaneous injection, typically in a clinical setting. The injection site is usually the thigh or abdomen, and the exact technique follows the prescribing information and local clinical guidelines.

The most serious risks include severe ovarian hyperstimulation syndrome, which can cause rapid weight gain, abdominal pain, and fluid accumulation, as well as rare allergic reactions such as anaphylaxis. Prompt medical attention is required if any signs of these conditions develop.

Meriofert should not be used by individuals with known hypersensitivity to any of its components, those with confirmed pregnancy, or patients with uncontrolled endocrine disorders that could exacerbate ovarian response. A thorough medical evaluation is required before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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