Product image of Meriofert Pfs (Follicle-Stimulating Hormone, Luteinising Hormone) supplied by GNH India

Meriofert Pfs

Active Ingredient:
Follicle-Stimulating Hormone, Luteinising Hormone
Origin:
EU

Meriofert Pfs (Follicle-Stimulating Hormone, Luteinising Hormone)

Follicle-Stimulating Hormone and Luteinising Hormone, the active ingredient in Meriofert Pfs, is a gonadotropin presented as a sterile injectable solution for subcutaneous use. It is employed to treat infertility caused by anovulation, to support controlled ovarian stimulation in assisted reproductive technologies, and to replace deficient hormones in hypogonadotropic hypogonadism.

GNH India supplies Meriofert Pfs as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality, regulatory compliance and reliable cold‑chain logistics.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Meriofert Pfs is used in reproductive medicine to address disorders of follicular development and hormone deficiency.

  • Infertility due to anovulation: promotes follicular growth and ovulation to improve chances of conception.
  • Controlled ovarian stimulation for assisted reproductive technologies: enhances multiple follicle development for IVF or ICSI cycles.
  • Hypogonadotropic hypogonadism: replaces deficient gonadotropins to restore normal ovarian function.

How It Works

  • Follicle‑Stimulating Hormone (FSH) and Luteinising Hormone (LH) in Meriofert Pfs bind to their respective receptors on ovarian granulosa and theca cells. Activation of FSH receptors stimulates granulosa cell proliferation and estradiol synthesis, while LH receptor activation promotes theca cell androgen production and final maturation of the dominant follicle, culminating in ovulation. The combined action mimics the natural pituitary surge, coordinating follicular development and luteinisation.

Side Effects

Adverse reactions to Meriofert Pfs may vary in frequency and severity.

Common Side Effects

  • Injection site pain: mild discomfort or erythema at the injection site.
  • Headache: transient headache reported by some patients.
  • Nausea: occasional mild nausea following administration.
  • Ovarian hyperstimulation syndrome (mild): abdominal bloating and mild discomfort.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (severe): rapid weight gain, ascites, and respiratory distress.
  • Thromboembolic events: rare cases of blood clots in veins or arteries.
  • Allergic reactions: anaphylaxis, urticaria, or angioedema requiring immediate medical attention.

Precautions & Warnings

When prescribing Meriofert Pfs, clinicians should consider several safety precautions.

  • Patient selection: assess baseline ovarian reserve and hormonal profile before initiation.
  • Monitoring: perform regular ultrasound and estradiol measurements to detect excessive response.
  • Contraindications: avoid use in active ovarian cysts, uncontrolled thyroid disease, or estrogen‑dependent tumors.
  • Pregnancy testing: confirm negative pregnancy test prior to starting therapy.
  • Drug interactions: review concomitant medications that may affect ovarian response.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Meriofert Pfs may interact with other agents that influence ovarian response or hormone metabolism.

Major Interactions (Avoid)

  • Gonadotropin‑releasing hormone (GnRH) antagonists: may blunt the intended ovarian stimulation.
  • High‑dose estrogen therapy: can suppress endogenous gonadotropin activity and reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Clomiphene citrate: concurrent use may increase risk of ovarian hyperstimulation.
  • Aromatase inhibitors: may alter estradiol levels and require dose adjustments.
  • Anticoagulants: monitor for thrombotic complications if severe ovarian hyperstimulation occurs.

Frequently Asked Questions

Meriofert Pfs is a gonadotropin preparation containing Follicle‑Stimulating Hormone and Luteinising Hormone. It is used to treat infertility caused by anovulation, to provide controlled ovarian stimulation for assisted reproductive technologies such as IVF, and to replace deficient gonadotropins in patients with hypogonadotropic hypogonadism.

FSH and LH bind to specific receptors on ovarian granulosa and theca cells. FSH stimulates granulosa cell proliferation and estradiol production, while LH promotes androgen synthesis in theca cells and supports the final maturation of the dominant follicle. Together they replicate the natural pituitary surge that leads to ovulation.

The dose of Meriofert Pfs is individualized. A qualified reproductive specialist evaluates the patient’s hormonal profile, ovarian reserve, and treatment goals, then prescribes the appropriate amount and schedule. Dosing may be adjusted based on monitoring of follicular response and estradiol levels.

Meriofert Pfs is not intended for use during an established pregnancy, and its safety in breastfeeding women has not been established. The product is typically administered before conception, and pregnancy testing is required before each treatment cycle. Use during pregnancy or lactation should only occur under specialist supervision.

To order Meriofert Pfs, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics where required) and any necessary import documentation.

Meriofert Pfs combines both FSH and LH in a single injectable formulation, which can simplify treatment regimens compared with using separate FSH‑only or LH‑only preparations. Its EU‑origin manufacturing follows stringent GMP standards, offering comparable efficacy and safety to other licensed gonadotropin brands while providing the convenience of a combined product.

Meriofert Pfs must be stored refrigerated at 2‑8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. If the product is inadvertently exposed to temperatures outside this range, it should not be used and a replacement should be requested.

Meriofert Pfs is supplied as a sterile injectable solution for subcutaneous injection. The medication is typically drawn into a syringe and injected into the subcutaneous tissue of the abdomen or thigh, following the dosing schedule prescribed by the treating physician. Proper aseptic technique and patient education are essential.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can cause rapid weight gain, abdominal distension, fluid accumulation, and respiratory compromise, as well as rare thromboembolic events and severe allergic reactions such as anaphylaxis. Patients should be monitored closely for early signs of these complications.

Meriofert Pfs is contraindicated in individuals with active ovarian cysts, uncontrolled thyroid disease, estrogen‑dependent tumors, or known hypersensitivity to any component of the formulation. It should also be avoided in patients who are already pregnant or who have a confirmed allergy to gonadotropin preparations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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